Zobrazeno 1 - 10
of 1 288
pro vyhledávání: '"A M Sykes"'
Publikováno v:
Journal of the Colleges of Medicine of South Africa, Vol 2, Iss 1 (2024)
No abstract available.
Externí odkaz:
https://doaj.org/article/ebbd7941094d4ff3a2b6d1bdba6797f3
Publikováno v:
Exploration of Medicine, Vol 4, Iss 5, Pp 695-708 (2023)
Aim: Parkinson’s disease (PD) is a complex, chronic neurodegenerative disorder with predominately sporadic etiology. Intricate genetic-environmental interactions lead to the hallmarks of the disease: degeneration of dopaminergic neurons and the dep
Externí odkaz:
https://doaj.org/article/8e18e86db3e34e0e83f3ac44691853c3
Publikováno v:
Journal of the Colleges of Medicine of South Africa, Vol 2, Iss 1, Pp e1-e5 (2024)
In the past, the doctor’s knowledge, clinical skills and judgement were the ‘main impetus for treatment decisions, therapy assessment and medical progress’, with the ‘emphasis being on protecting and restoring human well-being’. While the a
Externí odkaz:
https://doaj.org/article/24e6207bd4424553a706d8237a792947
Autor:
Maryam F. Afzali, Lauren B. Radakovich, Madeline M. Sykes, Margaret A. Campbell, Kayley M. Patton, Joseph L. Sanford, Nicole Vigon, Ryan Ek, Gerardo E. Narez, Angela J. Marolf, Katie J. Sikes, Tammy L. Haut Donahue, Kelly S. Santangelo
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-19 (2022)
Abstract Background The infrapatellar fat pad (IFP) is the largest adipose deposit in the knee; however, its contributions to the homeostasis of this organ remain undefined. To determine the influence of the IFP and its associated synovium (IFP/synov
Externí odkaz:
https://doaj.org/article/98c7c8a5a5484cd3a305dac724a1f4ed
Autor:
Manuela Völkner, Felix Wagner, Thomas Kurth, Alex M. Sykes, Claudia Del Toro Runzer, Lynn J. A. Ebner, Cagri Kavak, Vasileia Ismini Alexaki, Peter Cimalla, Mirko Mehner, Edmund Koch, Mike O. Karl
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Neurodegenerative diseases remain incompletely understood and therapies are needed. Stem cell-derived organoid models facilitate fundamental and translational medicine research. However, to which extent differential neuronal and glial pathologic proc
Externí odkaz:
https://doaj.org/article/b6df85ddea224a268d9f688df0becab5
Autor:
Oi-Wai Chau, Omar El-Sherif, Matthew Mouawad, Jane M Sykes, John Butler, Heather Biernaski, Robert deKemp, Jennifer Renaud, Gerald Wisenberg, Frank S Prato, Stewart Gaede
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0291854 (2023)
BackgroundLeft-sided breast cancer patients receiving adjuvant radiotherapy are at risk for coronary artery disease, and/or radiation mediated effects on the microvasculature. Previously our laboratory demonstrated in canines with hybrid 18FDG/PET a
Externí odkaz:
https://doaj.org/article/2135040d4b5b42e8994c5fc60899ca3a
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2023)
Parkinson’s disease (PD) is a chronic neurodegenerative disease that is characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain (SNpc). Extensive studies into genetic and cellular models of PD implicate
Externí odkaz:
https://doaj.org/article/9466d8dad023442083f13a20d31c0d0d
Autor:
Melissa A Hill, Steven R Bentley, Tara L Walker, George D Mellick, Stephen A Wood, Alex M Sykes
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271499 (2022)
The genetic study of multi-incident families is a powerful tool to investigate genetic contributions to the development of Parkinson's disease. In this study, we identified the rare PTPRA p.R223W variant as one of three putative genetic factors poten
Externí odkaz:
https://doaj.org/article/e6380aaca648487995106864725ef15d
Autor:
Iuliia O. Peshkova, Turan Aghayev, Aliia R. Fatkhullina, Petr Makhov, Elizaveta K. Titerina, Satoru Eguchi, Yin Fei Tan, Andrew V. Kossenkov, Marina V. Khoreva, Lyudmila V. Gankovskaya, Stephen M. Sykes, Ekaterina K. Koltsova
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Immune cells contribute to the aortic wall destruction during abdominal aortic aneurysm (AAA) development. Here, Peshkova et al. show that cytokine signaling through interleukin-27 receptor is required for Angiotensin II-induced myelopoiesis and matu
Externí odkaz:
https://doaj.org/article/b6343cfed5b940ac92570f7ff3c8787a
Publikováno v:
eLife, Vol 10 (2021)
GnRH neurons are the final central neural output regulating fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus (KNDy neurons) are considered the main regulator of GnRH output. GnRH and KNDy neurons are surrounded by astrocytes, which c
Externí odkaz:
https://doaj.org/article/8680cffae98d4bc8a4e2af661d57b5e4