Zobrazeno 1 - 10
of 135
pro vyhledávání: '"A M Randi"'
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Bleeding in the GI tract continues to pose a therapeutic challenge for clinicians in patients with Von Willebrand Disease (VWD). It is associated with significant morbidity and mortality and represents the major unmet need in VWD. Defective angiogene
Externí odkaz:
https://doaj.org/article/0d979f3fed14468ba9c31bbdf314bd8f
Autor:
Marie B. Lang, Kit-Yi Leung, Nicholas D.E. Greene, Kerri M. Malone, Gaye Saginc, Anna M. Randi, Allan Kiprianos, Robert T. Maughan, Charis Pericleous, Justin C. Mason
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ObjectivesThe disease-modifying anti-rheumatic drug methotrexate (MTX) is recognized to reduce cardiovascular risk in patients with systemic inflammatory diseases. However, the molecular basis for these cardioprotective effects remains incompletely u
Externí odkaz:
https://doaj.org/article/5d363a763a9c431a9c93d4a8e3417ea0
Autor:
Oisín King, Daniela Cruz-Moreira, Alaa Sayed, Fatemeh Kermani, Worrapong Kit-Anan, Ilona Sunyovszki, Brian X. Wang, Barrett Downing, Jerome Fourre, Daniel Hachim, Anna M. Randi, Molly M. Stevens, Marco Rasponi, Cesare M. Terracciano
Publikováno v:
Cell Reports: Methods, Vol 2, Iss 9, Pp 100280- (2022)
Summary: In this study, we report static and perfused models of human myocardial-microvascular interaction. In static culture, we observe distinct regulation of electrophysiology of human induced pluripotent stem cell derived-cardiomyocytes (hiPSC-CM
Externí odkaz:
https://doaj.org/article/69822f4eba4a4455b5192ffcbf3ed217
Autor:
C. Peghaire, N. P. Dufton, M. Lang, I. I. Salles-Crawley, J. Ahnström, V. Kalna, C. Raimondi, C. Pericleous, L. Inuabasi, R. Kiseleva, V. R. Muzykantov, J. C. Mason, G. M. Birdsey, A. M. Randi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via cooper
Externí odkaz:
https://doaj.org/article/7798914f5f094e87a7d8b776f5a7230c
Autor:
Theo Issitt, Emy Bosseboeuf, Natasha De Winter, Neil Dufton, Gaia Gestri, Valentina Senatore, Anissa Chikh, Anna M. Randi, Claudio Raimondi
Publikováno v:
iScience, Vol 11, Iss , Pp 205-223 (2019)
Summary: The transmembrane protein neuropilin-1 (NRP1) promotes vascular endothelial growth factor (VEGF) and extracellular matrix signaling in endothelial cells (ECs). Although it is established that NRP1 is essential for angiogenesis, little is kno
Externí odkaz:
https://doaj.org/article/3d93fbcc84b445d396a8543ea382f882
Autor:
Robert F. Sidonio, Jr, Paulette C. Bryant, Jorge Di Paola, Sarah Hale, Meadow Heiman, G Shellye Horowitz, Christi Humphrey, Julie Jaffray, Lora C. Joyner, Raj Kasthuri, Barbara A. Konkle, Peter A. Kouides, Robert Montgomery, Keith Neeves, Anna M. Randi, Nikole Scappe, Cristina Tarango, Kelly Tickle, Pamela Trapane, Michael Wang, Brittany Waters, Veronica H. Flood
Publikováno v:
Expert Review of Hematology. 16:39-54
BACKGROUND: Excessive or abnormal mucocutaneous bleeding (MCB) may impact all aspects of the physical and psychosocial wellbeing of those who live with it (PWMCB). The evidence base for the optimal diagnosis and management of disorders such as inheri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534acda1a65b49ca05e3ad1ab6f06be3
https://doi.org/10.1080/17474086.2023.2171983
https://doi.org/10.1080/17474086.2023.2171983
Autor:
null Ilham Albohari, null Eka Swajaya Putri, null Mawar Puspita sari, null M. Randi Briliansaputra, null Tomi Hidayat
Publikováno v:
Setawar Abdimas. 2:22-27
Kelurahan Malabero merupakan salah satu sentral masyarakat nelayan penghasil makanan laut (seafood) di Kota Bengkulu. Mata pencaharian nelayan Kelurahan Malabero berpotensi cukup besar dimana pada musim panen rata-rata setiap nelayan mampu memproduks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1456e38c7ab9fb65e956b2423299df4c
https://doi.org/10.36085/sa.v2i1.4796
https://doi.org/10.36085/sa.v2i1.4796
Autor:
Rakshin Kharwadkar, Benjamin J. Ulrich, Michelle Chu, Byunghee Koh, Matthew M. Hufford, Yongyao Fu, Graeme M. Birdsey, Bo T. Porse, Anna M. Randi, Mark H. Kaplan
Publikováno v:
The Journal of Immunology. 210:537-546
CD4+ TH cells develop into subsets that are specialized in the secretion of particular cytokines to mediate restricted types of inflammation and immune responses. Among the subsets that promote development of allergic inflammatory responses, IL-9–p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b7d6c84c4170873d620b8d400d2304
https://doi.org/10.4049/jimmunol.2200113
https://doi.org/10.4049/jimmunol.2200113
Autor:
Jesus M. Gomez-Salinero, Tomer Itkin, Sean Houghton, Chaitanya Badwe, Yang Lin, Viktoria Kalna, Neil Dufton, Claire R. Peghaire, Masataka Yokoyama, Matthew Wingo, Tyler M. Lu, Ge Li, Jenny Zhaoying Xiang, Yen-Michael Sheng Hsu, David Redmond, Ryan Schreiner, Graeme M. Birdsey, Anna M. Randi, Shahin Rafii
Publikováno v:
Nat Cardiovasc Res
Current dogma dictates that, during adulthood, endothelial cells (ECs) are locked in an immutable stable homeostatic state. By contrast, herein we show that maintenance of EC fate and function are linked and active processes, which depend on the cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58dc7f27b353db6352209a28670cb752
https://doi.org/10.1038/s44161-022-00128-3
https://doi.org/10.1038/s44161-022-00128-3
Autor:
Neil P. Dufton, Claire R. Peghaire, Lourdes Osuna-Almagro, Claudio Raimondi, Viktoria Kalna, Abhishek Chauhan, Gwilym Webb, Youwen Yang, Graeme M. Birdsey, Patricia Lalor, Justin C. Mason, David H. Adams, Anna M. Randi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The transcription factor ERG is key to endothelial lineage specification and vascular homeostasis. Here the authors show that ERG balances TGFβ signalling through the SMAD1 and SMAD3 pathways, protecting the endothelium from endothelial-to-mesenchym
Externí odkaz:
https://doaj.org/article/688d3e51bd6e4384bf9ccbf1181bb7d6