Zobrazeno 1 - 10
of 35
pro vyhledávání: '"A M Pilaro"'
Publikováno v:
Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743140900bc72eb87b804c1cdfc2b0c5
https://doi.org/10.1201/9781003064657-12
https://doi.org/10.1201/9781003064657-12
Autor:
Richard T. Lostritto, Martha Donoghue, Hong Zhao, Anshu Marathe, Anne M. Pilaro, Steven Lemery, Kun He, Stacy S. Shord, William M. Adams, Joseph E. Gootenberg, Lori Kotch, Liang Zhou, Rajeshwari Sridhara, Richard Pazdur, Weishi Yuan, Patricia Keegan, Vaishali Jarral, Ying Wang, Josephine M. Jee
Publikováno v:
Clinical Cancer Research. 18:1496-1505
This work describes the considerations that led to the approval by the U.S. Food and Drug Administration (FDA), on November 15, 2010, of eribulin mesylate (Halaven; Eisai, Inc.) for the treatment of patients with refractory metastatic breast cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47277393fccbd03e7bf2ea3b8057e66
https://doi.org/10.1158/1078-0432.ccr-11-2149
https://doi.org/10.1158/1078-0432.ccr-11-2149
Autor:
Tao Wang, William David McGuinn, David Jacobson-Kram, Abigail Jacobs, John C. Lipscomb, Daniel Lapadula, Paul Brown, Anne M. Pilaro
Publikováno v:
Toxicological Sciences. 118:356-367
Since the inception of the International Conference on Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH) in 1990, six-party Expert Working Groups (EWG) have developed and revised numerous guidelines o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c83e48c1db905ac7ffe453f8a8511c1
https://doi.org/10.1093/toxsci/kfq286
https://doi.org/10.1093/toxsci/kfq286
Autor:
Pengfei Song, Robert Justice, Shenghui Tang, Barbara L. Rellahan, Amy Tilley, Anne M. Pilaro, Amna Ibrahim, Wendy C. Weinberg, Somesh Chattopadhyay, Patricia Hughes, Nancy S. Scher, Qi Liu, Kimberly Ringgold, Gideon M. Blumenthal, Kathryn E. King, Bo Chi, Colleen Thomas, Laurie Graham, Richard Pazdur, Patricia Cortazar
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 19(18)
On June 8, 2012, the U.S. Food and Drug Administration (FDA) approved pertuzumab (Perjeta, Genentech) for use in combination with trastuzumab (Herceptin, Genentech) and docetaxel for the treatment of patients with HER2-positive metastatic breast canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f13cedae81963559c1b123b4c01e558
https://pubmed.ncbi.nlm.nih.gov/23801166
https://pubmed.ncbi.nlm.nih.gov/23801166
Publikováno v:
Biotherapy. 9:199-208
Recombinant human interleukin 1 alpha (rh IL-1 alpha) and etoposide (VP-16) synergize for direct growth inhibition of several human tumor cell lines in vitro. Our previous studies demonstrated that VP-16 increased the number of membrane-associated IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb30bbd1910386df99e3ea34e93cbdc
https://doi.org/10.1007/bf02620733
https://doi.org/10.1007/bf02620733
Autor:
Jerrold M. Ward, Robert H. Wiltrout, Akiko Kojima, Kunio Nagashima, Thomas J. Sayers, Kenji Kaneda, Theresa A. Wiltrout, Craig W. Reynolds, John R. Ortaldo, Matthew A. Gonda, Anne M. Pilaro
Publikováno v:
Biomedical Research. 17:53-65
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a23ccfebdb86023bed4a0715940cc7f1
https://doi.org/10.2220/biomedres.17.53
https://doi.org/10.2220/biomedres.17.53
Publikováno v:
Molecular Therapy. 8:8-10
and discussed their relevance to biologic products. Elesperu stated that genotoxicity assays are designed as surrogate assays to detect rare occurrences of genetic damage, and noted that although no single test alone will detect all types of mutageni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d151d07388a7e2fbfcc3c3133bfcd616
https://doi.org/10.1016/s1525-0016(03)00192-8
https://doi.org/10.1016/s1525-0016(03)00192-8
Publikováno v:
The Journal of Immunology. 153:333-342
Isolated murine splenic NK cells and the cultured murine endothelioma cell line, eEND2, were used to study the effects of cytokines on NK cell/endothelial cell adhesion. Treatment of eEND2 cells with TNF-alpha induced a marked increase (four- to seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16cd2527b462deee548a5bb9320f1b1f
https://doi.org/10.4049/jimmunol.153.1.333
https://doi.org/10.4049/jimmunol.153.1.333
Autor:
Matthew A. Gonda, Robert H. Wiltrout, Anne M. Pilaro, Thoma J. Sayers, John R. Ortaldo, Kenji Kaneda, Kunio Nagashima
Publikováno v:
Cell and Tissue Research. 276:187-195
Large granular lymphocytes (LGL) comprise a natural defense system in the liver and exert an inhibitory effect on tumor cell metastasis. In order to demonstrate the maturation of LGL in the liver from the morphological aspect, we evaluated electron-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7841d8a93c76a672324cdc3785957034
https://doi.org/10.1007/bf00354799
https://doi.org/10.1007/bf00354799