Výsledky vyhledávání

Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents

Autor: Ben J.A. Palanca, Peter Nagele, Molly C. Kalmoe, Alvin M. Janski, Charles F. Zorumski, Charles R. Conway

Publikováno v: Journal of the Neurological Sciences. 412:116778

N-methyl- d -aspartate receptor (NMDAR) antagonists, including ketamine and nitrous oxide, are currently intensely studied as rapid-acting antidepressant agents. Interestingly, both of these compounds are also drugs of abuse. Intravenous ketamine, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af69d51a0278824a84d5a3b70fa3b47
https://doi.org/10.1016/j.jns.2020.116778

Zobrazit plný text záznamu

Clinical characteristics and management of treatment-resistant depression

Autor: Alvin M. Janski, Marie C. Walker, Dragan M. Svrakic, Britt M. Gott, Charles R. Conway, Yvette I. Sheline, Marie Anne Gebara, Pilar Cristancho, John T. Chibnall, Christina N. Lessov-Schlaggar

Publikováno v: The Journal of clinical psychiatry. 76(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69af711a7872b19fee4704a1c2bfb46
https://pubmed.ncbi.nlm.nih.gov/26646033

Zobrazit plný text záznamu

Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial

Autor: Pilar Cristancho, Alireza Parsoei, Andreas Duma, Marie Anne Gebara, J. Philip Miller, Peter Nagele, Charles F. Zorumski, Charles R. Conway, Alvin M. Janski, Vassilis N. Panagopoulos, Michael Kopec, Marie C. Walker

Publikováno v: Biological Psychiatry, 78(1), 10-18. ELSEVIER SCIENCE INC

BackgroundN-methyl-D-aspartate receptor antagonists, such as ketamine, have rapid antidepressant effects in patients with treatment-resistant depression (TRD). We hypothesized that nitrous oxide, an inhalational general anesthetic and N-methyl-D-aspa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff23f74c5e21ae712aca6d785f5be44c
https://hdl.handle.net/1887/99485

Zobrazit plný text záznamu

Phosphorylation of ATP citrate lyase in response to glucagon

Autor: Paul A. Srere, N. W. Cornell, Richard L. Veech, A. M. Janski

Publikováno v: Journal of Biological Chemistry. 254:9365-9368

Incubation of hepatocytes with [32P]orthophosphate resulted in the incorporation of 32P into material that is precipitated by reaction with antibodies to ATP citrate lyase. The amount of radioactivity precipitated was decreased when unlabeled, purifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9a2a3ba0609ceb24c5884dc693d4d7d
https://doi.org/10.1016/s0021-9258(19)83525-1

Zobrazit plný text záznamu

The effect of solvents on nucleotide regulation of glycogen phosphorylase

Autor: A M Janski, R J Uhing, Donald J. Graves

Publikováno v: Journal of Biological Chemistry. 254:3166-3169

The activity of glycogen phosphorylase is controlled by two nucleotide sites. We have found that organic solvents affect the regulatory properties of phosphorylase by altering the binding at these two sites. At the activator site, the Ka for AMP is l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9e757bdba758765144107a1c0f83f20
https://doi.org/10.1016/s0021-9258(18)50738-9

Zobrazit plný text záznamu

Subcellular distribution of enzymes determined by rapid digitonin fractionation of isolated hepatocytes

Autor: Alvin M. Janski, Neal W. Cornell

Publikováno v: Biochemical Journal. 186:423-429

Conditions were determined for rapid separation of cytosolic and mitochondrial compartments by digitonin fractionation of rat hepatocytes. The minimum time required for separation of mitochondrial and cytosolic enzyme markers decreased rapidly with i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a2f8cbf4b256808c1c97897e32d40a
https://doi.org/10.1042/bj1860423

Zobrazit plný text záznamu

Inhibition by cycloserine of mitochondrial and cytosolic aspartate aminotransferase in isolated rat hepatocytes

Autor: N W Cornell, A M Janski

Publikováno v: Biochemical Journal. 194:1027-1030

Isolated hepatocytes were incubated with L-cycloserine and then treated with digitonin so that mitochondrial and cytosolic fractions were obtained in 5 s. Mitochondrial and total cellular aspartate aminotransferases (EC 2.6.1.1) were inactivated in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bda9625764d4a84e2f9f3d0185ee337
https://doi.org/10.1042/bj1941027

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání