Zobrazeno 1 - 10
of 362
pro vyhledávání: '"A M James Shapiro"'
Autor:
Mariusz Bral, Rena Pawlick, Braulio Marfil-Garza, Nidheesh Dadheech, Joshua Hefler, Aducio Thiesen, A M James Shapiro
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224567 (2019)
BACKGROUND:Liver ischemia reperfusion injury (IRI) remains a challenge in liver transplantation. A number of compounds have previously demonstrated efficacy in mitigating IRI. Herein, we applied three specific additive strategies to a mouse IRI scree
Externí odkaz:
https://doaj.org/article/30011a69f31944838f0cb63870e2fbaa
Autor:
Jordan J Nostedt, Tom Churchill, Sunita Ghosh, Aducio Thiesen, Jessica Hopkins, Mackenzie C Lees, Benjamin Adam, Darren H Freed, A M James Shapiro, David L Bigam
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220786 (2019)
BackgroundNormothermic machine perfusion (NMP) of liver grafts donated after circulatory death (DCD) has shown promise in large animal and clinical trials. Following procurement, initial flush with a cold preservation solution is the standard of care
Externí odkaz:
https://doaj.org/article/a346eb5f430048fc8d44c8aa021dca6e
Autor:
Mariusz Bral, Nader Aboelnazar, Sanaz Hatami, Aducio Thiesen, David L Bigam, Darren H Freed, A M James Shapiro
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215619 (2019)
BackgroundOne of the most promising applications of liver normothermic machine perfusion (NMP) is the potential to directly assess graft viability and injury. In most NMP studies, perfusate transaminases are utilized as markers of graft injury. Our a
Externí odkaz:
https://doaj.org/article/e2907b56c8374317a70ab98bf2a7870b
Autor:
Anissa Gamble, Rena Pawlick, Andrew R Pepper, Antonio Bruni, Adetola Adesida, Peter A Senior, Gregory S Korbutt, A M James Shapiro
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206449 (2018)
Islet transplantation is an established clinical procedure for select patients with type 1 diabetes and severe hypoglycemia to stabilize glycemic control. Post-transplant, substantial beta cell mass is lost, necessitating multiple donors to maintain
Externí odkaz:
https://doaj.org/article/3a3360ee0b3d4303b0fba7d6b04000b4
Autor:
Nasser Abualhassan, Lena Sapozhnikov, Rena L Pawlick, Meygal Kahana, Andrew R Pepper, Antonio Bruni, Boris Gala-Lopez, Tatsuya Kin, Eduardo Mitrani, A M James Shapiro
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156053 (2016)
There is a need to develop three-dimensional structures that mimic the natural islet tissue microenvironment. Endocrine micro-pancreata (EMPs) made up of acellular organ-derived micro-scaffolds seeded with human islets have been shown to express high
Externí odkaz:
https://doaj.org/article/c0029110f4674193b3e98e1214a41fb7
Autor:
Alessandro Parente, MD, PhD, Kevin Verhoeff, MD, PhD, Tatsuya Kin, MD, PhD, Joshua Hefler, MD, PhD, Braulio A. Marfil-Garza, MD, PhD, Norberto Sanchez-Fernandez, MD, Anna Lam, MD, MSc, James Lyon, MD, PhD, Doug O’Gorman, BSc, Khaled Z. Dajani, MD, Blaire L. Anderson, MD, David L. Bigam, MD, MSc, Patrick E. MacDonald, MD, PhD, A. M. James Shapiro, MD, PhD, FRCS (Eng), FRCSC, MSM
Publikováno v:
Transplantation Direct, Vol 10, Iss 7, p e1667 (2024)
Background. Limited information is available regarding outcomes of islet cell isolation (ICI) and transplantation (ITx) using medical assistance in dying (MAiD) donors. We aimed to assess the feasibility and outcomes of ICI and ITx in MAiD donors. Me
Externí odkaz:
https://doaj.org/article/71afa965af904b5c8fc2cf5045e23fbe
Autor:
Alexandre S Raposo do Amaral, Rena L Pawlick, Erika Rodrigues, Flavia Costal, Andrew Pepper, Flávio H Ferreira Galvão, Maria Lucia Correa-Giannella, A M James Shapiro
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55288 (2013)
The success of pancreatic islet transplantation still faces many challenges, mainly related to cell damage during islet isolation and early post-transplant. The increased generation of reactive oxygen species (ROS) during islet isolation and the cons
Externí odkaz:
https://doaj.org/article/a2f5b81ad0ec44528eba129dcc389e7b
Autor:
Telford Y Yeung, Karen L Seeberger, Tatsuya Kin, Adetola Adesida, Nadr Jomha, A M James Shapiro, Gregory S Korbutt
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38189 (2012)
Transplantation of human islets is an attractive alternative to daily insulin injections for patients with type 1 diabetes. However, the majority of islet recipients lose graft function within five years. Inflammation is a primary contributor to graf
Externí odkaz:
https://doaj.org/article/974b5a59c0d94d79b03dff9cffcc8aba
Autor:
Kevin Verhoeff, Braulio A. Marfil-Garza, Khaled Dajani, David L. Bigam, Blaire Anderson, Tatsuya Kin, Anna Lam, Doug O’Gorman, Peter A. Senior, A. M. James Shapiro
Publikováno v:
Transplantation. 107:774-781
Autor:
Kevin Verhoeff, Braulio A Marfil-Garza, Zofia Czarnecka, Nerea Cuesta-Gomez, Ila Tewari Jasra, Nidheesh Dadheech, Peter A Senior, A M James Shapiro
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism.
Historically, only patients with brittle diabetes or severe recurrent hypoglycemia have been considered for islet transplantation (ITx). This population has been selected to optimize the risk-benefit profile considering risks of long-term immunosuppr