Zobrazeno 1 - 10
of 71
pro vyhledávání: '"A M Efanov"'
Autor:
O. Melekhina, M. Efanov, R. Alikhanov, V. Tsvirkun, Y. Kulezneva, I. Kazakov, A. Vankovich, A. Koroleva, I. Khatkov
Publikováno v:
BJS Open, Vol 4, Iss 1, Pp 101-108 (2020)
Background Percutaneous radiofrequency‐assisted liver partition with portal vein embolization in staged liver resection (PRALPPS) represents an alternative to portal vein embolization (PVE) followed by major liver resection in patients with perihil
Externí odkaz:
https://doaj.org/article/bef12032145047cea19609b83c92614e
Autor:
Hua V. Lin, Jingru Wang, Jie Wang, Weiji Li, Xuesong Wang, James T. Alston, Melissa K. Thomas, Daniel A. Briere, Samreen K. Syed, Alexander M. Efanov
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 205-211 (2018)
Objective: GPR142 agonists are being pursued as novel diabetes therapies by virtue of their insulin secretagogue effects. But it is undetermined whether GPR142's functions in pancreatic islets are limited to regulating insulin secretion. The current
Externí odkaz:
https://doaj.org/article/51a98efe956c4a619df0f0a69c4863d8
Autor:
Samreen K. Syed, David Gene Barrett, Francis S. Willard, Karen Leigh Cox, Dirk Tomandl, Alexander M. Efanov, Luyan Song
Publikováno v:
ASSAY and Drug Development Technologies. 19:27-37
Phenotypic screening is a neoclassical approach for drug discovery. We conducted phenotypic screening for insulin secretion enhancing agents using INS-1E insulinoma cells as a model system for pancreatic beta-cells. A principal regulator of insulin s
Autor:
Jinsook Son, Hongxu Ding, Thomas B. Farb, Alexander M. Efanov, Jiajun Sun, Julie L. Gore, Samreen K. Syed, Zhigang Lei, Qidi Wang, Domenico Accili, Andrea Califano
Publikováno v:
J Clin Invest
Type 2 diabetes (T2D) is associated with defective insulin secretion and reduced β cell mass. Available treatments provide a temporary reprieve, but secondary failure rates are high, making insulin supplementation necessary. Reversibility of β cell
Autor:
Hua V Lin, Alexander M Efanov, Xiankang Fang, Lisa S Beavers, Xuesong Wang, Jingru Wang, Isabel C Gonzalez Valcarcel, Tianwei Ma
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157298 (2016)
GPR142, a putative amino acid receptor, is expressed in pancreatic islets and the gastrointestinal tract, but the ligand affinity and physiological role of this receptor remain obscure. In this study, we show that in addition to L-Tryptophan, GPR142
Externí odkaz:
https://doaj.org/article/6917374dbc7842d4acc4d2e702ee5f13
Autor:
E. Willems, M. D'Hondt, P.T. Kingham, D. Fuks, G.-H. Choi, N. Syn, I. Sucandy, M.V. Marino, M. Prieto Calvo, C.C.N. Chong, J.-H. Lee, M. Efanov, A.K. Chiow, S.-H. Choi, R. Sutcliffe, R.I. Troisi, J. Pratschke, T.-T. Cheung, X.-Y. Wang, R. Liu, C.N. Tang, H.-S. Han, B.K.P. Goh
Publikováno v:
HPB. 24:S162-S163
Autor:
Andrew C. Adams, Jill A. Willency, Qian Yang, Keyun Qing, Xiaojun Wang, Minrong Ai, Alexander M. Efanov, Xiao-peng Yu, Andrea Renee Geiser, Paul J. Emmerson, Jianliang Lu, Jorge Alsina-Fernandez, Tamer Coskun, Brandy M. Snider, Emily C Beebe, Lili Guo
Publikováno v:
Journal of the Endocrine Society
Oxytocin (OXT) has been shown to suppress appetite, induce weight loss, and improve glycemic control and lipid metabolism in several species, including humans, monkeys, and rodents. However, OXT’s short half-life in circulation and lack of receptor
Autor:
May Yun Wang, Greg Poffenberger, Philipp E. Scherer, William L. Holland, Reshing Ye, Ruth E. Gimeno, Yiyi Zhang, Kyle W. Sloop, Derek C. Leonard, S. Kay McCorkle, Alexander M. Efanov, Roger H Unger, Yi Zhu, Alison Von Deylen, Alvin C. Powers, E. Danielle Dean, Shiuhwei Chen, Kamrul H. Chowdhury, Shangang Zhao, Zhuzhen Zhang, Xinxin Yu, Young Chul Lee, Ezekiel B. Quittner-Strom, Na Li, Amnon Schlegel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Both type 1 and type 2 diabetes are associated with reduced β-cell mass or function, resulting from decreased proliferation and increased apoptosis. Understanding the signals governing β-cell survival and regeneration is critical for d
Autor:
Mariano Cesare Giglio, Lotte C. Franken, Hauke Lang, Andrea Ruzzenente, Francesca Ratti, Jens Rolinger, L.M. Quinn, Andreas Andreou, Christian Benzing, E. Pando, Stefan Büttner, Matteo Serenari, H. Jansson, Cornelius H. C. Dejong, Luca Aldrighetti, M. Malagó, S. van Laarhoven, Roberto Troisi, Keith J. Roberts, P.R. deReuver, Matteo Cescon, E. de Savornin Lohman, Hassan Malik, J. N. M. Ijzermans, C. Gomez-Gavara, Marjolein A P Ligthart, P.B. Olthof, Ivan Capobianco, Fabian Bartsch, M. Efanov, Moritz Schmelzle, Ruslan Alikhanov, Silvio Nadalin, G. Frascaroli, Alfredo Guglielmi, F. Heid, B. Groot Koerkamp, J.L.A. vanVugt, S.W.M. Olde Damink, T.M. vanGulik, Johann Pratschke, A. Sultana, Shishir K. Maithel, Ernesto Sparrelid, Erik Schadde, Paolo Muiesan, Joris I. Erdmann, William R. Jarnagin
In the original article Moritz Schmelzle’s last name is spelled wrong. It is correct as reflected here.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948a776d30e60f54daf3682fe418932a
https://hdl.handle.net/2434/954473
https://hdl.handle.net/2434/954473
Autor:
Marta Adeva, Samreen K. Syed, Thomas B. Farb, Xin Zhou, Thomas James Beauchamp, David Andrew Coates, Francis S. Willard, Tamika D. Meredith, Susan L. Gackenheimer, Michael A. Statnick, Maria Angeles Martinez-Grau, Miguel A. Toledo, Brian A. Droz, James Ficorilli, Alexander M. Efanov, Gema Ruano, Over Cabrera, Todd M. Suter, Victoriano Molero, Krister Bokvist, David Gene Barrett
Publikováno v:
Endocrinology. 158:3859-3873
Incretin and insulin responses to nutrient loads are suppressed in persons with diabetes, resulting in decreased glycemic control. Agents including sulfonylureas and dipeptidyl peptidase-4 inhibitors (DPP4i) partially reverse these effects and provid