Zobrazeno 1 - 10
of 85
pro vyhledávání: '"A M D'Antona"'
Autor:
Aaron M. D’Antona, Julie M. Lee, Melvin Zhang, Clarence Friedman, Tao He, Lidia Mosyak, Eric Bennett, Laura Lin, Maddison Silverman, Funi Cometa, Caryl Meade, Tyler Hageman, Eric Sousa, Justin Cohen, Kimberly Marquette, Darren Ferguson, Xiaotian Zhong
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1931 (2024)
Structure and function of therapeutic antibodies can be modulated by a variety of post-translational modifications (PTM). Tyrosine (Tyr) sulfation is a type of negatively charged PTM that occurs during protein trafficking through the Golgi. In this s
Externí odkaz:
https://doaj.org/article/ee1664fedb7941809a1c37ea5cd17195
Autor:
Xiaotian Zhong, Aaron M. D’Antona
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The diversity of three hypervariable loops in antibody heavy chain and light chain, termed the complementarity-determining regions (CDRs), defines antibody’s binding affinity and specificity owing to the direct contact between the CDRs and antigens
Externí odkaz:
https://doaj.org/article/757c4e6aca5b4b6e8b004edc7e6c84a0
Autor:
Jing Zhou, Guoying Grace Yan, David Cluckey, Caryl Meade, Margaret Ruth, Rhady Sorm, Amy S. Tam, Sean Lim, Constantine Petridis, Laura Lin, Aaron M. D’Antona, Xiaotian Zhong
Publikováno v:
Antibodies, Vol 12, Iss 3, p 53 (2023)
Rapidly producing drug-like antibody therapeutics for lead molecule discovery and candidate optimization is typically accomplished by large-scale transient gene expression technologies (TGE) with cultivated mammalian cells. The TGE methodologies have
Externí odkaz:
https://doaj.org/article/6e54a51f86d04d0d932d46ed2ecdfea1
Autor:
Adam R. Root, Gurkan Guntas, Madan Katragadda, James R. Apgar, Jatin Narula, Chew Shun Chang, Sara Hanscom, Matthew McKenna, Jason Wade, Caryl Meade, Weijun Ma, Yongjing Guo, Yan Liu, Weili Duan, Claire Hendershot, Amy C. King, Yan Zhang, Eric Sousa, Amy Tam, Susan Benard, Han Yang, Kerry Kelleher, Fang Jin, Nicole Piche-Nicholas, Sinead E. Keating, Fernando Narciandi, Rosemary Lawrence-Henderson, Maya Arai, Wayne R. Stochaj, Kristine Svenson, Lidia Mosyak, Khetemcnee Lam, Christopher Francis, Kimberly Marquette, Liliana Wroblewska, H. Lily Zhu, Alfredo Darmanin Sheehan, Edward R. LaVallie, Aaron M. D’Antona, Alison Betts, Lindsay King, Edward Rosfjord, Orla Cunningham, Laura Lin, Puja Sapra, Lioudmila Tchistiakova, Divya Mathur, Laird Bloom
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
We report here the discovery and optimization of a novel T cell retargeting anti-GUCY2C x anti-CD3ε bispecific antibody for the treatment of solid tumors. Using a combination of hybridoma, phage display and rational design protein engineering, we ha
Externí odkaz:
https://doaj.org/article/25a52ae4f12b462d933f760c7786789d
Autor:
James R Apgar, Amy S P Tam, Rhady Sorm, Sybille Moesta, Amy C King, Han Yang, Kerry Kelleher, Denise Murphy, Aaron M D'Antona, Guoying Yan, Xiaotian Zhong, Linette Rodriguez, Weijun Ma, Darren E Ferguson, Gregory J Carven, Eric M Bennett, Laura Lin
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232713 (2020)
For an antibody to be a successful therapeutic many competing factors require optimization, including binding affinity, biophysical characteristics, and immunogenicity risk. Additional constraints may arise from the need to formulate antibodies at hi
Externí odkaz:
https://doaj.org/article/cc94f4a62bcb4df1920dad454aac1825
Publikováno v:
Antibodies, Vol 11, Iss 1, p 5 (2022)
Glycans as sugar polymers are important metabolic, structural, and physiological regulators for cellular and biological functions. They are often classified as critical quality attributes to antibodies and recombinant fusion proteins, given their imp
Externí odkaz:
https://doaj.org/article/d86b2f7fc5674a1b9c7cf7c6ad10df18
Autor:
Xiaotian Zhong, Aaron M. D’Antona
Publikováno v:
Antibodies, Vol 10, Iss 2, p 13 (2021)
Recombinant protein-based biotherapeutics drugs have transformed clinical pipelines of the biopharmaceutical industry since the launch of recombinant insulin nearly four decades ago. These biologic drugs are structurally more complex than small molec
Externí odkaz:
https://doaj.org/article/5df28ad846a8472eb68b13ef6c7265c2
Publikováno v:
EAI Endorsed Transactions on Creative Technologies, Vol 3, Iss 6, Pp 1-11 (2016)
Today, many forms of art are influenced by the emergence of interactive technologies, including the mixing of physical media with digital technology for forming new hybrid works of art and the usage of mobile phones to create art projected on public
Externí odkaz:
https://doaj.org/article/dd991a947dd04892b7a1baf6a0da5219
Publikováno v:
Antibodies
Glycans as sugar polymers are important metabolic, structural, and physiological regulators for cellular and biological functions. They are often classified as critical quality attributes to antibodies and recombinant fusion proteins, given their imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f118751d787988f8775fb6532d83fbdf
https://pubmed.ncbi.nlm.nih.gov/35076453
https://pubmed.ncbi.nlm.nih.gov/35076453
Autor:
Weijun Ma, Aaron M. D’Antona, Caryl L. Meade, Xiaotian Zhong, Jing Zhou, Ashley Schwab, Laura Lin, William S. Somers
Publikováno v:
Therapeutic Antibodies ISBN: 9781071614495
Large-scale transient expression in Chinese Hamster Ovary (CHO) cells provides a rapid protein production method with a potential start-to-end alignment advantage for biotherapeutics drug discovery. In this chapter, experimental protocols are illustr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c40f2d060234af827155c94db561a629
https://doi.org/10.1007/978-1-0716-1450-1_7
https://doi.org/10.1007/978-1-0716-1450-1_7
