Zobrazeno 1 - 10
of 121
pro vyhledávání: '"A M Cypess"'
Autor:
Jessica D. Kepple, Yanping Liu, Teayoun Kim, Cheryl Cero, James W. Johnson, Glenn C. Rowe, Aaron M. Cypess, Kirk M. Habegger, Martin Young, Chad S. Hunter
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101284- (2021)
Objective: Brown adipose tissue (BAT) is critical for thermogenesis and glucose/lipid homeostasis. Exploiting the energy uncoupling capacity of BAT may reveal targets for obesity therapies. This exploitation requires a greater understanding of the tr
Externí odkaz:
https://doaj.org/article/fa6c61723738419489af22749dacd08d
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
β3-Adrenergic receptors (β3-ARs) are the predominant regulators of rodent brown adipose tissue (BAT) thermogenesis. However, in humans, the physiological relevance of BAT and β3-AR remains controversial. Herein, using primary human adipocytes from
Externí odkaz:
https://doaj.org/article/76331fef2122485d889d38be91fd6594
Autor:
Umesh D. Wankhade, Ji-Hyeon Lee, Pradeep K. Dagur, Hariom Yadav, Michael Shen, Weiping Chen, Ashok B. Kulkarni, J. Philip McCoy, Toren Finkel, Aaron M. Cypess, Sushil G. Rane
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 160-171 (2018)
Objective: Beige/brite adipose tissue displays morphological characteristics and beneficial metabolic traits of brown adipose tissue. Previously, we showed that TGF-β signaling regulates the browning of white adipose tissue. Here, we inquired whethe
Externí odkaz:
https://doaj.org/article/0a4593b69adf4e4488d472817a18ddae
Autor:
Matthew D. Lynes, Farnaz Shamsi, Elahu Gosney Sustarsic, Luiz O. Leiria, Chih-Hao Wang, Sheng-Chiang Su, Tian Lian Huang, Fei Gao, Niven R. Narain, Emily Y. Chen, Aaron M. Cypess, Tim J. Schulz, Zachary Gerhart-Hines, Michael A. Kiebish, Yu-Hua Tseng
Publikováno v:
Cell Reports, Vol 24, Iss 3, Pp 781-790 (2018)
Summary: Thermogenic fat expends energy during cold for temperature homeostasis, and its activity regulates nutrient metabolism and insulin sensitivity. We measured cold-activated lipid landscapes in circulation and in adipose tissue by MS/MSALL shot
Externí odkaz:
https://doaj.org/article/e2d80919fceb41beb08fe7076406da4f
Autor:
Rókus Kriszt, Satoshi Arai, Hideki Itoh, Michelle H. Lee, Anna G. Goralczyk, Xiu Min Ang, Aaron M. Cypess, Andrew P. White, Farnaz Shamsi, Ruidan Xue, Jung Yeol Lee, Sung-Chan Lee, Yanyan Hou, Tetsuya Kitaguchi, Thankiah Sudhaharan, Shin’ichi Ishiwata, E. Birgitte Lane, Young-Tae Chang, Yu-Hua Tseng, Madoka Suzuki, Michael Raghunath
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The identification of brown adipose deposits in adults has led to significant interest in targeting this metabolically active tissue for treatment of obesity and diabetes. Improved methods for the direct measurement of heat production as the
Externí odkaz:
https://doaj.org/article/52a314579272494397c0203168538870
Autor:
Ling Xiao, Dario F. De Jesus, Cheng-Wei Ju, Jiang-Bo Wei, Jiang Hu, Ava DiStefano-Forti, Tadataka Tsuji, Cheryl Cero, Ville Männistö, Suvi M. Manninen, Siying Wei, Oluwaseun Ijaduola, Matthias Blüher, Aaron M. Cypess, Jussi Pihlajamäki, Yu-Hua Tseng, Chuan He, Rohit N. Kulkarni
Publikováno v:
bioRxiv
SummaryBrown adipose tissue (BAT) has the capacity to regulate systemic metabolism through the secretion of signaling lipids. N6-methyladenosine (m6A) is the most prevalent and abundant post-transcriptional mRNA modification and has been reported to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf4fddf70655d42ce1538dbad8d716e
https://europepmc.org/articles/PMC10245942/
https://europepmc.org/articles/PMC10245942/
Autor:
Satoru Sugimoto, Hebe Agustina Mena, Brian E. Sansbury, Shio Kobayashi, Tadataka Tsuji, Chih-Hao Wang, Xuanzhi Yin, Tian Lian Huang, Joji Kusuyama, Sean D. Kodani, Justin Darcy, Gerson Profeta, Nayara Pereira, Rudolph E. Tanzi, Can Zhang, Thomas Serwold, Efi Kokkotou, Laurie J. Goodyear, Aaron M. Cypess, Luiz Osório Leiria, Matthew Spite, Yu-Hua Tseng
Publikováno v:
Nature Metabolism. 4:775-790
Obesity induces chronic inflammation resulting in insulin resistance and metabolic disorders. Cold exposure can improve insulin sensitivity in humans and rodents, but the mechanisms have not been fully elucidated. Here, we find that cold resolves obe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65bcee7616f604fa3fdfa0ea77949eb7
https://doi.org/10.1038/s42255-022-00590-0
https://doi.org/10.1038/s42255-022-00590-0
Autor:
Anushka Gupta, Farnaz Shamsi, Nicolas Altemose, Gabriel F. Dorlhiac, Aaron M. Cypess, Andrew P. White, Nir Yosef, Mary Elizabeth Patti, Yu-Hua Tseng, Aaron Streets
Publikováno v:
Genome research, vol 32, iss 2
Single-cell RNA sequencing (scRNA-seq) enables molecular characterization of complex biological tissues at high resolution. The requirement of single-cell extraction, however, makes it challenging for profiling tissues such as adipose tissue, for whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ca03e7a91c476b89cda8c0f498a0c8
https://doi.org/10.1101/gr.275509.121
https://doi.org/10.1101/gr.275509.121
Autor:
Janane F, Rahbani, Charlotte, Scholtes, Damien M, Lagarde, Mohammed F, Hussain, Anna, Roesler, Christien B, Dykstra, Jakub, Bunk, Bozena, Samborska, Shannon L, O'Brien, Emma, Tripp, Alain, Pacis, Anthony R, Angueira, Olivia S, Johansen, Jessica, Cinkornpumin, Ishtiaque, Hossain, Matthew D, Lynes, Yang, Zhang, Andrew P, White, William A, Pastor, Maria, Chondronikola, Labros, Sidossis, Samuel, Klein, Anastasia, Kralli, Aaron M, Cypess, Steen B, Pedersen, Niels, Jessen, Yu-Hua, Tseng, Zachary, Gerhart-Hines, Patrick, Seale, Davide, Calebiro, Vincent, Giguère, Lawrence, Kazak
Publikováno v:
Nature metabolism. 4(11)
Noradrenaline (NA) regulates cold-stimulated adipocyte thermogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f3b3487f1088e41970c519982e02956
https://pubmed.ncbi.nlm.nih.gov/36344764
https://pubmed.ncbi.nlm.nih.gov/36344764
Autor:
Vibha Singhal, Giovana D Maffazioli, Kathryn E Ackerman, Hang Lee, Elisa F Elia, Ryan Woolley, Gerald Kolodny, Aaron M Cypess, Madhusmita Misra
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160129 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0156353.].
Externí odkaz:
https://doaj.org/article/3b34bc4388314d03873a5af3246c3a96