IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation

Autor: Wida Razawy, Celso H. Alves, Marijke Koedam, Patrick S. Asmawidjaja, Adriana M. C. Mus, Mohamed Oukka, Pieter J. M. Leenen, Jenny A. Visser, Bram C. J. van der Eerden, Erik Lubberts

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Abstract The IL-23 receptor (IL-23R) signaling pathway has pleiotropic effects on the differentiation of osteoclasts and osteoblasts, since it can inhibit or stimulate these processes via different pathways. However, the potential role of this pathwa

Externí odkaz: https://doaj.org/article/4178bd5619304f8498fcb69ed29bb6bc

1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade

Autor: Wendy Dankers, Claudia González-Leal, Nadine Davelaar, Patrick S. Asmawidjaja, Adriana M. C. Mus, Johanna M. W. Hazes, Edgar M. Colin, Erik Lubberts

Publikováno v: Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018)

Abstract Background Despite recent improvements in the treatment of rheumatoid arthritis (RA), an insufficient treatment response and the development of treatment resistance in many patients illustrates the need for new therapeutic strategies. Chroni

Externí odkaz: https://doaj.org/article/3a07dc2ca00a40bcbb47638e4912b65b

IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation

Autor: Pieter J. M. Leenen, Wida Razawy, Celso H. Alves, Jenny A. Visser, Erik Lubberts, Marijke Koedam, Adriana M. C. Mus, Patrick S. Asmawidjaja, Mohamed Oukka, Bram C. J. van der Eerden

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, 11(1):10244. Nature Publishing Group

The IL-23 receptor (IL-23R) signaling pathway has pleiotropic effects on the differentiation of osteoclasts and osteoblasts, since it can inhibit or stimulate these processes via different pathways. However, the potential role of this pathway in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa1cb9c3b2155a317b6455513af8231
https://doi.org/10.1038/s41598-021-89625-2

Achieving sustained minimal disease activity with methotrexate in early interleukin 23-driven early psoriatic arthritis

Autor: Erik Lubberts, Marijn Vis, Priyanka S Bangoer, Johanna M. W. Hazes, Marc R. Kok, Ilja Tchetverikov, Adriana M. C. Mus, Nadine Davelaar, Jolanda J. Luime, K. Wervers, Hannah den Braanker

Publikováno v: RMD Open, 6(2):e001175. BMJ Publishing Group
RMD Open
RMD Open, Vol 6, Iss 2 (2020)

ObjectivesMethotrexate (MTX) is currently the recommended first-line therapy for treating psoriatic arthritis (PsA), despite lacking clear evidence. No estimates of efficacy of MTX in usual care and no clear MTX responsive clinical or laboratory vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d8580c9e9803bc61bb2d5fe543ad56
https://pure.eur.nl/en/publications/37f69860-75f2-4354-a73a-e2b6743fec8b

1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade

Autor: Patrick S. Asmawidjaja, E. M. Colin, Johanna M. W. Hazes, Adriana M. C. Mus, Erik Lubberts, Claudia González-Leal, Wendy Dankers, Nadine Davelaar

Publikováno v: Arthritis research & therapy, 20(1). BioMed Central
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018)
Arthritis Research & Therapy, 20:212. BioMed Central Ltd.

Background Despite recent improvements in the treatment of rheumatoid arthritis (RA), an insufficient treatment response and the development of treatment resistance in many patients illustrates the need for new therapeutic strategies. Chronic synovia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412640b24994ee8cdde81e7270c41333
https://doi.org/10.1186/s13075-018-1706-9