Zobrazeno 1 - 10
of 150
pro vyhledávání: '"A M Michie"'
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2234-2254 (2024)
Acute myeloid leukaemia (AML) is a clonal haematological malignancy affecting the myeloid lineage, with generally poor patient outcomes owing to the lack of targeted therapies. The histone lysine demethylase 4A (KDM4A) has been established as a novel
Externí odkaz:
https://doaj.org/article/b5af769d2f424fc290ecf499a014771f
Autor:
Hannah Donnelly, Ewan Ross, Yinbo Xiao, Rio Hermantara, Aqeel F. Taqi, W. Sebastian Doherty-Boyd, Jennifer Cassels, Penelope. M. Tsimbouri, Karen M. Dunn, Jodie Hay, Annie Cheng, R. M. Dominic Meek, Nikhil Jain, Christopher West, Helen Wheadon, Alison M. Michie, Bruno Peault, Adam G. West, Manuel Salmeron-Sanchez, Matthew J. Dalby
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Long-term reconstituting haematopoietic stem cells (LT-HSCs) are used to treat blood disorders via stem cell transplantation. The very low abundance of LT-HSCs and their rapid differentiation during in vitro culture hinders their clinical ut
Externí odkaz:
https://doaj.org/article/e8984c0b474a49c1b8fa3b60f306f23a
Autor:
Mary T. Scott, Wei Liu, Rebecca Mitchell, Cassie J. Clarke, Ross Kinstrie, Felix Warren, Hassan Almasoudi, Thomas Stevens, Karen Dunn, John Pritchard, Mark E. Drotar, Alison M. Michie, Heather G. Jørgensen, Brian Higgins, Mhairi Copland, David Vetrie
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Whilst it is recognised that targeting self-renewal is an effective way to functionally impair the quiescent leukaemic stem cells (LSC) that persist as residual disease in chronic myeloid leukaemia (CML), developing therapeutic strategies to
Externí odkaz:
https://doaj.org/article/7d71f15f83a5445383d3246089c36b76
Autor:
Kevin M. Rattigan, Zuzana Brabcova, Daniele Sarnello, Martha M. Zarou, Kiron Roy, Ryan Kwan, Lucie de Beauchamp, Amy Dawson, Angela Ianniciello, Ahmed Khalaf, Eric R. Kalkman, Mary T. Scott, Karen Dunn, David Sumpton, Alison M. Michie, Mhairi Copland, Saverio Tardito, Eyal Gottlieb, G. Vignir Helgason
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Deregulated oxidative metabolism is a hallmark of leukaemia. While tyrosine kinase inhibitors (TKIs) such as imatinib have increased survival of chronic myeloid leukaemia (CML) patients, they fail to eradicate disease-initiating leukemic ste
Externí odkaz:
https://doaj.org/article/f6923fc9708841a5bf7e890a6863e86a
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Forkhead box (FOX) class O (FOXO) proteins are a dynamic family of transcription factors composed of four family members: FOXO1, FOXO3, FOXO4 and FOXO6. As context-dependent transcriptional activators and repressors, the FOXO family regulates diverse
Externí odkaz:
https://doaj.org/article/7eb6c9ca4b1a4d25b90afdfd74299e6a
Publikováno v:
Hemato, Vol 2, Iss 3, Pp 556-571 (2021)
Acute myeloid leukaemia (AML) is a haematological cancer with poor outcomes due to a lack of efficacious targeted therapies. The Nuclear Factor of Activated T Cells (NFAT) family of transcription factors is well characterised as a regulator of the ce
Externí odkaz:
https://doaj.org/article/a7948ca22b954a4a96da1c9551126150
Autor:
Matthew E. Massett, Laura Monaghan, Shaun Patterson, Niamh Mannion, Roderick P. Bunschoten, Alex Hoose, Sandra Marmiroli, Robert M. J. Liskamp, Heather G. Jørgensen, David Vetrie, Alison M. Michie, Xu Huang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-16 (2021)
Abstract Epigenomic dysregulation is a common pathological feature in human hematological malignancies. H3K9me3 emerges as an important epigenomic marker in acute myeloid leukemia (AML). Its associated methyltransferases, such as SETDB1, suppress AML
Externí odkaz:
https://doaj.org/article/c6caf5a67a024f7385a2936b34f65413
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/d6c51cbd322f445ebba3c7d9ce09e187
Autor:
Alison M. Michie, Alison M. McCaig, Sabina C. Cosulich, Owen J. Sansom, Michael T. Leach, Declan O'Rourke, Sylvie M. Guichard, Alan M. Macdonald, Karen M. Dunn, Jodie Hay, Mark A. Catherwood, Natasha Malik, Ailsa K. Holroyd, Michael W. Moles, Anuradha Tarafdar, Emilio Cosimo
Suppl Figure 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a76fb5a12fa22dae21d498da22adeb5
https://doi.org/10.1158/1078-0432.22472687.v1
https://doi.org/10.1158/1078-0432.22472687.v1
Autor:
Alison M. Michie, Laurent Meijer, Hervé Galons, Nassima Oumata, Emilie Durieu, Christian Berthou, Karine Le Ster, Michael T. Leach, Helen Wheadon, Luke J.M. Carter-Brzezinski, Alison M. McCaig, Emilio Cosimo
PDF file - 56K, CR8 induces CLL cell apoptosis independently of clinical parameters upon treatment at 300 nM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d2414ac2c89ec8228d25d8b9342dd0
https://doi.org/10.1158/1078-0432.22450079.v1
https://doi.org/10.1158/1078-0432.22450079.v1