Questions and answers in the management of children with medulloblastoma over the time. How did we get here? A systematic review

Autor: Marta P. Osuna-Marco, Laura I. Martín-López, Águeda M. Tejera, Blanca López-Ibor

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

IntroductionTreatment of children with medulloblastoma (MB) includes surgery, radiation therapy (RT) and chemotherapy (CT). Several treatment protocols and clinical trials have been developed over the time to maximize survival and minimize side effec

Externí odkaz: https://doaj.org/article/52998ef435d042fe8b97c0e4f74d65da

Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations

Autor: Elisa Varela, Miguel A. Muñoz-Lorente, Agueda M. Tejera, Sagrario Ortega, Maria A. Blasco

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)

Telomere shortening has been linked to some aspects of organismal ageing. Here the authors create chimaeric mice that contain a mix of cells with normal or unnaturally long telomeres, and show chimaeric mice are protected from some forms of ageing-as

Externí odkaz: https://doaj.org/article/d0106904dff5400da6c8a5952d1b3cbb

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

Autor: Bruno Bernardes de Jesus, Elsa Vera, Kerstin Schneeberger, Agueda M. Tejera, Eduard Ayuso, Fatima Bosch, Maria A. Blasco

Publikováno v: EMBO Molecular Medicine, Vol 4, Iss 8, Pp 691-704 (2012)

Abstract A major goal in aging research is to improve health during aging. In the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity. Based on this, we have tested the effe

Externí odkaz: https://doaj.org/article/9b339a05152245db843dd446a714c398

A synthetic mRNA cell reprogramming method using CYCLIN D1 promotes DNA repair generating improved genetically stable human induced pluripotent stem cells

Autor: Michael J. Edel, Carme Grau-Bove, Francisco Vidal Pérez, Manel Juan Otero, Raul Delgado-Morales, Maria A. Blasco, Carlos Hobeich Naya, Agueda M. Tejera, Alejandro Vaquero, C. Barrot, Irene Santos-Barriopedro, Iris Garcia-Martínez, Ana Belén Alvarez-Palomo, Manel Esteller, Jovita Mezquita-Pla, Sebastian Moran, Victoria Moreno-Manzano, Jordi Requena-Osete

Publikováno v: STEM CELLS
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

A key challenge for clinical application of induced pluripotent stem cells (iPSC) to accurately model and treat human pathologies depends on developing a method to generate genetically stable cells to reduce long-term risks of cell transplant therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b21653ddfbbf30e81baf22d70748f4
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3661

ATRX driver mutation in a composite malignant pheochromocytoma

Autor: Laura Remacha, Alberto Cascón, Agueda M. Tejera, Maria A. Blasco, Pablo Gonzalvo, Iñaki Comino-Méndez, Maria Currás-Freixes, Mercedes Robledo, Raul Tonda, Rocío Letón

Publikováno v: Cancer Genetics. 209:272-277

Pheochromocytomas (PCCs) and paragangliomas (PGLs) are tumors arising from the adrenal medulla and sympathetic/parasympathetic paraganglia, respectively. Approximately 40% of PCCs/PGLs are due to germline mutations in one of 16 susceptibility genes,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c7186ce8c840673f0d7f3ef8ad4d03
https://doi.org/10.1016/j.cancergen.2016.04.058