Zobrazeno 1 - 10
of 76
pro vyhledávání: '"A M, Snowman"'
Autor:
Urbain Weyemi, Bindu D. Paul, Adele M. Snowman, Parthav Jailwala, Andre Nussenzweig, William M. Bonner, Solomon H. Snyder
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
H2AX is a histone variant with an essential function in DNA double-strand break repair and genome stability. Here, Weyemi and colleagues show that loss of neuronal H2AX leads to locomotor dysfunction and alteration in oxidative stress response.
Externí odkaz:
https://doaj.org/article/253374c82ccd40c5a5caef64387f25f3
Autor:
Chirag Vasavda, Risheng Xu, Jason Liew, Ruchita Kothari, Ryan S. Dhindsa, Evan R. Semenza, Bindu D. Paul, Dustin P. Green, Mark F. Sabbagh, Joseph Y. Shin, Wuyang Yang, Adele M. Snowman, Lauren K. Albacarys, Abhay Moghekar, Carlos A. Pardo-Villamizar, Mark Luciano, Judy Huang, Chetan Bettegowda, Shawn G. Kwatra, Xinzhong Dong, Michael Lim, Solomon H. Snyder
Publikováno v:
Science advances. 8(31)
Trigeminal neuralgia, historically dubbed the “suicide disease,” is an exceedingly painful neurologic condition characterized by sudden episodes of intense facial pain. Unfortunately, the only U.S. Food and Drug Administration (FDA)–approved me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cabc7afd9518e36431b9f1a2ca7cad5
https://pubmed.ncbi.nlm.nih.gov/35921423
https://pubmed.ncbi.nlm.nih.gov/35921423
Autor:
Maged M. Harraz, Adarsha P. Malla, Evan R. Semenza, Maria Shishikura, Manisha Singh, Yun Hwang, In Guk Kang, Young Jun Song, Adele M. Snowman, Pedro Cortés, Senthilkumar S. Karuppagounder, Ted M. Dawson, Valina L. Dawson, Solomon H. Snyder
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Cocaine is a monoamine transport inhibitor. Current models attributing pharmacologic actions of cocaine to inhibiting the activity of the amine transporters alone failed to translate to the clinic. Cocaine inhibition of the dopamine, ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fe02ba05d540959d3a5dc2d47bac82
https://doi.org/10.1073/pnas.2200545119
https://doi.org/10.1073/pnas.2200545119
Autor:
Chirag Vasavda, Evan R. Semenza, Jason Liew, Ruchita Kothari, Ryan S. Dhindsa, Shruthi Shanmukha, Anthony Lin, Robert Tokhunts, Cristina Ricco, Adele M. Snowman, Lauren Albacarys, Francesco Pastore, Cristian Ripoli, Claudio Grassi, Eugenio Barone, Michael D. Kornberg, Xinzhong Dong, Bindu D. Paul, Solomon H. Snyder
Publikováno v:
Sci Signal
Synapses connect discrete neurons into vast networks that send, receive, and encode diverse forms of information. Synaptic function and plasticity, the neuronal process of adapting to diverse and variable inputs, depend on the dynamic nature of synap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab16c00860509c7df599719e2e65f02f
http://hdl.handle.net/10807/214469
http://hdl.handle.net/10807/214469
Autor:
Milos R. Filipovic, Biljana Bursac, Bindu D. Paul, Matthew Whiteman, Juan I. Sbodio, Thomas W. Sedlak, Lauren M. Albacarys, Thibaut Vignane, Sumedha Nalluru, Adele M. Snowman, Daniel Giovinazzo, Roberta Torregrossa, Solomon H. Snyder
Publikováno v:
Proceedings of the National Academy of Sciences
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Alzheimer’s disease (AD), the most common cause of dementia and neurodegeneration in the elderly, is characterized by deterioration of memory and executive and motor functions. Neuropathologic hallmarks of AD include neurofibrillary tangles (NFTs),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00186ecab6eabb3fc6e2b432a2366f4
Autor:
Chirag Vasavda, Lauren K. Albacarys, Ruchita Kothari, Evan R. Semenza, Robert Tokhunts, Jason Liew, Solomon H. Snyder, Adele M. Snowman, Cristina Ricco, Shruthi Shanmukha, Bindu D. Paul, Ryan S. Dhindsa
Synapses are complex bridges that connect discrete neurons into vast networks that send, receive, and encode diverse forms of information. However, they must remain dynamic in order to adapt to changing inputs. Here, we report that the enzyme biliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::026623c054097ba912bf2681fd2148e1
https://doi.org/10.1101/2020.12.01.405720
https://doi.org/10.1101/2020.12.01.405720
Autor:
Adarsha P. Malla, Young Jun Song, Maged M. Harraz, Evan R. Semenza, Adele M. Snowman, Yun Hwang, In Guk Kang, Solomon H. Snyder, Pedro Cortés, Maria Shishikura
Cocaine is a behavioral stimulant with substantial abuse potential related to its positively rewarding actions1,2. Cocaine inhibits the reuptake inactivation of neurotransmitters such as dopamine, serotonin, and norepinephrine at high nanomolar to lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866d747f41ac00138254bd7443e4cadc
https://doi.org/10.1101/2020.11.23.392787
https://doi.org/10.1101/2020.11.23.392787
Autor:
Vasanta Putluri, Peter A. Calabresi, Solomon H. Snyder, Paul M. Kim, Pavan Bhargava, Michael D. Kornberg, Nagireddy Putluri, Adele M. Snowman
Publikováno v:
Science. 360:449-453
Immunometabolism as therapeutic target Dimethyl fumarate (DMF) is an immunomodulatory compound used to treat multiple sclerosis and psoriasis whose mechanisms of action remain only partially understood. Kornberg et al. found that DMF and its metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929b397b19027395846850aa65f4dff7
https://doi.org/10.1126/science.aan4665
https://doi.org/10.1126/science.aan4665
Autor:
Bindu D. Paul, William M. Bonner, Parthav Jailwala, Urbain Weyemi, André Nussenzweig, Adele M. Snowman, Solomon H. Snyder
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature Communications
ATM drives DNA repair by phosphorylating the histone variant H2AX. While ATM mutations elicit prominent neurobehavioral phenotypes, neural roles for H2AX have been elusive. We report impaired motor learning and balance in H2AX-deficient mice. Mitigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ca2e50976387cde05b1c75b77621cc
https://doaj.org/article/253374c82ccd40c5a5caef64387f25f3
https://doaj.org/article/253374c82ccd40c5a5caef64387f25f3
Autor:
Tomas Rojas, Chenglai Fu, Jing Xu, Maged M. Harraz, Weiwei Cheng, Solomon H. Snyder, Alfred C. Chin, Adele M. Snowman
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2036-2041
Inositol hexakisphosphate kinase 1 (IP6K1), which generates 5-diphosphoinositol pentakisphosphate (5-IP7), physiologically mediates numerous functions. We report that IP6K1 deletion leads to brain malformation and abnormalities of neuronal migration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bce2ec5ffba0cacb1ec758bf739c2c
https://doi.org/10.1073/pnas.1700165114
https://doi.org/10.1073/pnas.1700165114