Zobrazeno 1 - 10
of 25
pro vyhledávání: '"A M, Seacat"'
Autor:
James D. Yager, Andrew M. Seacat, Michael A. Trush, Periannan Kuppusamy, Jay L. Zweier, Yunbo Li
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 518:123-133
The biotransformation of butylated hydroxyanisole (BHA), a possible carcinogenic food antioxidant, includes o-demethylation to 2-tert-butyl(1,4)hydroquinone (TBHQ) which can subsequently be oxidized to 2-tert-butyl(1,4)paraquinone (TBQ). In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32d58f22cf9ed00357b8eb8b70f74f3
https://doi.org/10.1016/s1383-5718(02)00073-6
https://doi.org/10.1016/s1383-5718(02)00073-6
Publikováno v:
Archives of Biochemistry and Biophysics. 347:45-52
Catechol estrogens are genotoxic, indirectly through redox cycling mechanisms leading to oxidative DNA damage and directly by formation of quinone-DNA adducts. Previously, we demonstrated that Cu2+ can oxidize estradiol (E2) catechols, establishing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09c81e081c94230face8e763adc332e
https://doi.org/10.1006/abbi.1997.0323
https://doi.org/10.1006/abbi.1997.0323
Autor:
James D. Yager, Angelika Tritscher, Thomas R. Sutter, Douglas A. Bell, Brian D. Miller, George W. Lucier, Andrew M. Seacat, John D. Groopman
Publikováno v:
Cancer Letters. 98:219-225
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a more potent hepatocarcinogen in female than in male or ovariectomized rats. A possible mechanism for this increased sensitivity is through enhanced metabolic activation of estrogens by TCDD-induced enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ce8ccdc8e3015b54d18b1d03972dc03
https://doi.org/10.1016/s0304-3835(06)80035-2
https://doi.org/10.1016/s0304-3835(06)80035-2
Publikováno v:
The Journal of Pediatrics. 126:S125-S129
The purposes of this article are to introduce a formal definition of nipple confusion and to propose various hypotheses concerning its cause. The term nipple confusion refers to an infant's difficulty in achieving the correct oral configuration, latc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644b1f1c7f2474824bd16fff8c78e811
https://doi.org/10.1016/s0022-3476(95)90252-x
https://doi.org/10.1016/s0022-3476(95)90252-x
Autor:
Jean M. Burris, Geary W. Olsen, John W. Froehlich, Larry R. Zobel, John L. Butenhoff, Andrew M. Seacat, David J. Ehresman
Publikováno v:
Environmental Health Perspectives
Perfluorooctanesulfonate [PFOS; CF3(CF2)7SO3−] and its acid salts were derived from perfluorooctanesulfonyl fluoride [POSF; CF3(CF2)7SO2F]. Major product applications were developed using POSF through formation of N-alkylsulfonamides that were used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e703eb53dfe006d19f2d518eec65067
https://pubmed.ncbi.nlm.nih.gov/17805419
https://pubmed.ncbi.nlm.nih.gov/17805419
Autor:
John L. Butenhoff, Andrew M. Seacat, M. W. Anders, Thomas R. Tephly, Daria M. Krenitsky, Lin Xu
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 34(8)
N-Alkylperfluorooctanesulfonamides have been used in a range of industrial and commercial applications. Perfluorooctanesulfonamide (FOSA) is a major metabolite of N-alkylperfluorooctanesulfonamides and has a long half-life in animals and in the envir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c987c2cb1bacd9b2a7ce06e49a7d340d
https://pubmed.ncbi.nlm.nih.gov/16720684
https://pubmed.ncbi.nlm.nih.gov/16720684
Autor:
Geary W. Olsen, Gerald L. Kennedy, Andrew M. Seacat, Lisa B. Biegel, John C. O'Connor, John L. Butenhoff, David G. Farrar, Roger Perkins, Sandra R. Murphy
Publikováno v:
Critical reviews in toxicology. 34(4)
PFOA is a peroxisome proliferator (PPAR agonist) and exerts morphological and biochemical effects characteristic of PPAR agonists. These effects include increased beta-oxidation of fatty acids, increases in several cytochrome P-450 (CYP450)-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1e1ad80b818aecdb6f5f86532c3038
https://pubmed.ncbi.nlm.nih.gov/15328768
https://pubmed.ncbi.nlm.nih.gov/15328768
Autor:
Fred L. DeRoos, John L. Butenhoff, Christopher H. Hurst, Sue S. Tanaka, David J. Waxman, Andrew M. Seacat, Jonathan M. Shipley
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 80(1)
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that activate target genes involved in lipid metabolism, energy homeostasis, and cell differentiation in response to diverse compounds, including environme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb75631219e43d530375828eb9d6b8e
https://pubmed.ncbi.nlm.nih.gov/15071170
https://pubmed.ncbi.nlm.nih.gov/15071170
Autor:
John L. Butenhoff, Sandra R Eldridge, Andrew M. Seacat, Lisa A Clemen, Peter J. Thomford, Cliff Elcombe, Kris J Hansen
Publikováno v:
Toxicology. 183(1-3)
Perfluorooctanesulfonate (PFOS) is a widely disseminated persistent compound found at low (part-per-billion) concentrations in serum and liver samples from humans and fish-eating wildlife. This study investigated the hypotheses that early hepatocellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901ca64693b7956d05020b92a2349cd3
https://pubmed.ncbi.nlm.nih.gov/12504346
https://pubmed.ncbi.nlm.nih.gov/12504346
Publikováno v:
Toxicology. 176(3)
Liver-fatty acid binding protein (L-FABP) is an abundant intracellular lipid-carrier protein. The hypothesis that perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and certain related perfluorooctanesulfonamide-based fluorochemicals (PFOSAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b9f139a369d2f5980ad0a6a072ba23
https://pubmed.ncbi.nlm.nih.gov/12093614
https://pubmed.ncbi.nlm.nih.gov/12093614