Zobrazeno 1 - 10
of 69
pro vyhledávání: '"A M, Pooler"'
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 12, Pp 2302-2308 (2021)
Abstract The primary dystonia DYT6 is caused by mutations in the transcription factor Thanatos‐associated protein 1 (THAP1). To understand THAP1’s functions, we generated mice lacking THAP1 in the nervous system. THAP1 loss causes locomotor defic
Externí odkaz:
https://doaj.org/article/dc03a1e4306d4887b62541ccad0970dc
Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons
Autor:
Teresa Rodríguez-Martín, Amy M. Pooler, Dawn H.W. Lau, Gábor M. Mórotz, Kurt J. De Vos, Jonathan Gilley, Michael P. Coleman, Diane P. Hanger
Publikováno v:
Neurobiology of Disease, Vol 85, Iss , Pp 1-10 (2016)
Expression of the frontotemporal dementia-related tau mutation, P301L, at physiological levels in adult mouse brain (KI-P301L mice) results in overt hypophosphorylation of tau and age-dependent alterations in axonal mitochondrial transport in periphe
Externí odkaz:
https://doaj.org/article/4d3a2fdfc4214f45aec1f1bd18eaaefc
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 12, Pp 2302-2308 (2021)
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology
The primary dystonia DYT6 is caused by mutations in the transcription factor Thanatos‐associated protein 1 (THAP1). To understand THAP1’s functions, we generated mice lacking THAP1 in the nervous system. THAP1 loss causes locomotor deficits assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71cc8ca64c4afa3ffedbc736b81e9039
https://doaj.org/article/dc03a1e4306d4887b62541ccad0970dc
https://doaj.org/article/dc03a1e4306d4887b62541ccad0970dc
Persistent repression of tau in the brain using engineered zinc finger protein transcription factors
Autor:
Susanne Wegmann, Bradley T. Hyman, Annemarie Ledeboer, Jeffrey C. Miller, Marta Perez-Rando, Kimberly Marlen, Richard T. Surosky, Bryan Zeitler, Caitlin Commins, Alison Chase, Michael C. Holmes, Sarah J. Hinkley, Alicia Goodwin, Riley N. Bannon, Lei Zhang, Brigit E. Riley, Hoang-Oanh B. Nguyen, Sarah L. DeVos, Edward J. Rebar, Ashley B. Robbins, Stephen Lam, Rainier Amora, Irina Ankoudinova, Qi Yu, Amy M. Pooler, Hung Tran, Nicholas A. Scarlott, Bianca T. Corjuc, Danny MacKenzie, Fyodor D. Urnov, H. Steve Zhang, Lisa Diez, Rachel E. Bennett
Publikováno v:
Science advances 7(12), eabe1611-(2021). doi:10.1126/sciadv.abe1611
Science Advances
Science Advances
Zinc finger proteins targeted to MAPT safely repress tau mRNA in the adult mouse brain and protect against Aβ toxicity.
Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we in
Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1e249560ae8a0539e415f467dba78e
Autor:
M. Pooler
Publikováno v:
Acta Horticulturae. :1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c615569ff98b39a17a2831fdcca36ae5
https://doi.org/10.17660/actahortic.2017.1185.1
https://doi.org/10.17660/actahortic.2017.1185.1
Autor:
Alfonso M. Lechuga-Sancho, Tara L. Spires-Jones, Amy M. Pooler, Brian J. Bacskai, Juan Jose Ramos-Rodriguez, Monica Garcia-Alloza
Publikováno v:
Ramos-Rodriguez, J J, Spires-Jones, T, Pooler, A M, Lechuga-Sancho, A M, Bacskai, B J & Garcia-Alloza, M 2016, ' Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer's Disease ', Molecular Neurobiology, vol. 53 . https://doi.org/10.1007/s12035-016-9921-3
Age remains the main risk factor for developing Alzheimer's disease (AD) although certain metabolic alterations, including prediabetes and type 2 diabetes (T2D), may also increase this risk. In order to understand this relationship, we have studied a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1db30766f16504e5b399e649fa1726
https://doi.org/10.1007/s12035-016-9921-3
https://doi.org/10.1007/s12035-016-9921-3
Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice
Autor:
Brian H. Anderton, Laura Sturdee, Michael P. Coleman, Jean Pierre Brion, Diane P. Hanger, Jonathan Gilley, Teresa Rodriguez-Martin, Amy M. Pooler, Kunie Ando, Anjan Seereeram
Publikováno v:
Neurobiology of aging, 39
Gilley, J, Ando, K, Seereeram, A, Rodríguez-Martín, T, Pooler, A M, Sturdee, L, Anderton, B H, Brion, J-P, Hanger, D P & Coleman, M P 2016, ' Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice ', Neurobiology of Aging, vol. 39, pp. 1-18 . https://doi.org/10.1016/j.neurobiolaging.2015.11.028
Gilley, J, Ando, K, Seereeram, A, Rodríguez-Martín, T, Pooler, A M, Sturdee, L, Anderton, B H, Brion, J-P, Hanger, D P & Coleman, M P 2016, ' Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice ', Neurobiology of Aging, vol. 39, pp. 1-18 . https://doi.org/10.1016/j.neurobiolaging.2015.11.028
Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau are key features of Alzheimer's disease and other tauopathies. To investigate the involvement of tau phosphorylation in the pathological process, we generated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd259b2f04784efb0849659337928c3
https://doi.org/10.1016/j.neurobiolaging.2015.11.028
https://doi.org/10.1016/j.neurobiolaging.2015.11.028
Publikováno v:
Acta Horticulturae. :49-58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28556cf1dd22ad8107a86bd3afbaf541
https://doi.org/10.17660/actahortic.2015.1087.5
https://doi.org/10.17660/actahortic.2015.1087.5
Publikováno v:
Neuropharmacology. 76:1-8
Alzheimer's disease (AD) is characterized by brain deposition of amyloid plaques and tau neurofibrillary tangles along with steady cognitive decline. Although the mechanism by which AD pathogenesis occurs is unclear, accumulating evidence suggests th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6322c92adb07bea379a42b09915a7c
https://doi.org/10.1016/j.neuropharm.2013.09.018
https://doi.org/10.1016/j.neuropharm.2013.09.018
Autor:
Kevin R Kay, Tara L. Spires-Jones, Laura Sanchez, Amy M. Pooler, Teresa Gomez-Isla, Rose Pitstick, Bradley T. Hyman, George A. Carlson, Manuela Polydoro, Susanne Wegmann, Mark W. Albers
Publikováno v:
Journal of Comparative Neurology. 521:4236-4248
Early observations of the patterns of neurofibrillary tangles and amyloid plaques in Alzheimer's disease suggested a hierarchical vulnerability of neurons for tangles, and a widespread nonspecific pattern of plaques that nonetheless seemed to correla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e617a76297cad90929c4b6d5c193905
https://doi.org/10.1002/cne.23411
https://doi.org/10.1002/cne.23411