Zobrazeno 1 - 10
of 45
pro vyhledávání: '"A M, Mjalli"'
Autor:
Otis C Attucks, Kimberly J Jasmer, Mark Hannink, Jareer Kassis, Zhenping Zhong, Suparna Gupta, Sam F Victory, Mustafa Guzel, Dharma Rao Polisetti, Robert Andrews, Adnan M M Mjalli, Matthew J Kostura
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101044 (2014)
Oxidative stress is generated by reactive oxygen species (ROS) produced in response to metabolic activity and environmental factors. Increased oxidative stress is associated with the pathophysiology of a broad spectrum of inflammatory diseases. Cellu
Externí odkaz:
https://doaj.org/article/38eade4d89ec47ada08bb991933d34cb
Autor:
Dharmesh D. Desai, Jane M. Shen, Eitan M. Akirav, Robert Rothlein, Kevan C. Herold, Jeffery C. Webster, Yali Chen, Octavian Henegariu, Wei Chen, Bernhard Moser, Robert C. Andrews, Raphael Clynes, Adnan M. M. Mjalli, Ann Marie Schmidt
Publikováno v:
The Journal of Immunology. 181:4272-4278
The pattern recognition receptor, RAGE, has been shown to be involved in adaptive immune responses but its role on the components of these responses is not well understood. We have studied the effects of a small molecule inhibitor of RAGE and the del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef37ffb3deb4d287b8c14c7ac3ef6456
https://doi.org/10.4049/jimmunol.181.6.4272
https://doi.org/10.4049/jimmunol.181.6.4272
Publikováno v:
Current Drug Discovery Technologies. 3:189-197
Computer assisted, or in silico, drug discovery approaches play an important role in the search for small molecule hits and leads. These include structure- and ligand-based methods, as well as data mining and QSAR. They are used to analyze and predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbc5054576284ee4517857d765c141c
https://doi.org/10.2174/157016306780136790
https://doi.org/10.2174/157016306780136790
Autor:
Mohan Rao, Robert C. Andrews, Robert Rothlein, Tove' C. Bolken, Murty N. Arimilli, Adnan M. M. Mjalli, Tariq Andrea, Katrina L. Owens, Dennis E. Hruby, Chelsea M. Byrd
Publikováno v:
Journal of Virology. 78:12147-12156
By using a homology-based bioinformatics approach, a structural model of the vaccinia virus (VV) I7L proteinase was developed. A unique chemical library of ∼51,000 compounds was computationally queried to identify potential active site inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867200c4d3e5550ccf18313468507bbb
https://doi.org/10.1128/jvi.78.22.12147-12156.2004
https://doi.org/10.1128/jvi.78.22.12147-12156.2004
Autor:
Carmen Valcarce, Mark S. Kindy, Matthew J. Kostura, Aaron H. Burstein, Dharma Rao Polisetti, Adnan M. M. Mjalli, Robert K. Andrews
Publikováno v:
Alzheimer's & Dementia. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::492f2061e36705fc93c60ceec8570131
https://doi.org/10.1016/j.jalz.2014.05.1119
https://doi.org/10.1016/j.jalz.2014.05.1119
Autor:
Paul S. Aisen, Marwan N. Sabbagh, Adnan M M Mjalli, Douglas Galasko, Aaron H Burstein, Imogene Grimes
Publikováno v:
BMC Neurology
Background TTP488, an antagonist at the Receptor for Advanced Glycation End products, was evaluated as a potential treatment for patients with mild-to-moderate Alzheimer’s disease (AD). A previous report describes decreased decline in ADAS-cog (del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d575970ffd575514fcfcbae2d5d8f4df
https://doi.org/10.1186/1471-2377-14-12
https://doi.org/10.1186/1471-2377-14-12
Autor:
Adnan M. M. Mjalli, Jie-Fei Cheng
Publikováno v:
Tetrahedron Letters. 39:939-942
Solid-phase synthesis of Δ2-isoxazolines through a 1,3-dipolar cycloaddition of nitrile oxides is described. The aldoxime is oxidized with commercially available bleach to give the corresponding nitrile oxide, which reacts in situ with dipolarophile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84543ea926713da2977ddfafb1817db2
https://doi.org/10.1016/s0040-4039(97)10700-6
https://doi.org/10.1016/s0040-4039(97)10700-6
Publikováno v:
Tetrahedron. 53:6653-6679
The potential of the Ugi 4CC reaction has been explored with regard to the preparation of large combinatorial libraries of small organic molecules of varying structures. These include smallring lactams, α-(dialkylamino)amides, hydantoin 4-imides, 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81c1f8e85c322fe38be6d824b5685c44
https://doi.org/10.1016/s0040-4020(97)00223-8
https://doi.org/10.1016/s0040-4020(97)00223-8
Autor:
Adnan M. M. Mjalli, Kevin M. Short
Publikováno v:
Tetrahedron Letters. 38:359-362
The synthesis of small-ring lactams via the condensation of ω-ketoacids, isocyanides and amines is reported. This process is shown to proceed well in a combinatorial fashion, by immobilization of the isocyanide component on Wang resin. The product i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8898c312fd386c4d85202d2a3b06af1
https://doi.org/10.1016/s0040-4039(96)02303-9
https://doi.org/10.1016/s0040-4039(96)02303-9
Autor:
Matthew J. Kostura, Attucks Otis Clinton, Mustafa Guzel, Samuel Victory, Jareer Kassis, Suparna Gupta, Michal L. Schwartzman, Dharma Rao Polisetti, Adnan M. M. Mjalli, Nader G. Abraham
Publikováno v:
Hypertension. 62
We report for the first time a novel class of compounds that specifically modulate the Bach1 transcriptional repressor pathway. In cellula, the compounds selectively inhibit the activity of the transcriptional repressor Bach1 resulting in transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22d672dd44ec4228e180c4350c63cc16
https://doi.org/10.1161/hyp.62.suppl_1.a71
https://doi.org/10.1161/hyp.62.suppl_1.a71