Zobrazeno 1 - 10
of 20
pro vyhledávání: '"A M, Misenheimer"'
Publikováno v:
Biochemical Journal
The mechanism of generation of factor VIIa, considered the initiating protease in the tissue factor-initiated extrinsic limb of blood coagulation, is obscure. Decreased levels of plasma VIIa in individuals with congenital factor IX deficiency suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371c665d0579a1006ed41cb31f7b62c1
https://doi.org/10.1042/bcj20190595
https://doi.org/10.1042/bcj20190595
Publikováno v:
Biochemistry. 46:7886-7895
Heparin inhibits the intrinsic tenase complex (factor IXa-factor VIIIa) via interaction with a factor IXa exosite. To define the role of this exosite, human factor IXa with alanine substituted for conserved surface residues (R126, N129, K132, R165, N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be37559ed1ae0f1754072b1c16afdc80
https://doi.org/10.1021/bi7004703
https://doi.org/10.1021/bi7004703
Autor:
Emily T. Beebe, Jonathan Peters, Brian G. Fox, David J. Aceti, Bo Li, Alan M. Jones, Daisuke Urano, Shin-ichi Makino, Tina M. Misenheimer
Publikováno v:
Protein expression and purification. 126
Arabidopsis thaliana Regulator of G protein Signalling 1 (AtRGS1) is a protein with a predicted N-terminal 7-transmembrane (7TM) domain and a C-terminal cytosolic RGS1 box domain. The RGS1 box domain exerts GTPase activation (GAP) activity on Gα (At
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b429a15084c3c0ad74a2317e690d53c
https://pubmed.ncbi.nlm.nih.gov/27164033
https://pubmed.ncbi.nlm.nih.gov/27164033
Autor:
Tina M. Misenheimer, Deane F. Mosher
Publikováno v:
Journal of Biological Chemistry. 280:41229-41235
The signature domain of thrombospondins consists of tandem epidermal growth factor-like modules, 13 calcium-binding repeats, and a lectin-like module. Although very similar, the signature domains of thrombospondin-1 and -2 differ in several potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b39d5cf8a60ba36774cab4fb36ad2e
https://doi.org/10.1074/jbc.m504696200
https://doi.org/10.1074/jbc.m504696200
Autor:
Douglas S. Annis, Douglas A. Bernstein, Deane F. Mosher, Blue-leaf A. Hannah, C. Britt, Tina M. Misenheimer, James L. Keck
Publikováno v:
Nature Structural & Molecular Biology. 12:910-914
Thrombospondins (TSPs) are a family of five secreted multimodular metallo/glycoproteins that have diverse roles involving interactions between cells and the extracellular matrix{Adams, 2004 #3568}. For TSP-2, these functions are critical for such pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a09d58758cd950913c670b8352bbd7
https://doi.org/10.1038/nsmb997
https://doi.org/10.1038/nsmb997
Publikováno v:
Journal of Biological Chemistry. 279:51915-51922
A single nucleotide polymorphism that results in substitution at residue 700 of a serine (Ser-700) for an asparagine (Asn-700) in thrombospondin-1 is associated with familial premature coronary artery disease. The polymorphism is located in the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed0ddfb850e98725bc91269906d0be1
https://doi.org/10.1074/jbc.m409632200
https://doi.org/10.1074/jbc.m409632200
Publikováno v:
Biochemistry. 42:5125-5132
The C-terminal regions of thrombospondins (TSPs) contain three elements, EGF-like modules (E), a series of Ca(2+)-binding repeats (Ca), and a C-terminal sequence (G). We have looked for interactions among these elements in four recombinant proteins b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993ea19baf4151265c9b9a7f2331e996
https://doi.org/10.1021/bi026983p
https://doi.org/10.1021/bi026983p
Publikováno v:
Journal of Biological Chemistry. 278:8929-8934
A single nucleotide polymorphism that substitutes a serine for an asparagine at residue 700 in the Ca2+-binding repeats of thrombospondin-1 is associated with familial premature coronary heart disease. We expressed the Ca2+-binding repeats alone (Ca)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626cb469d6a7e076122b61829072aefb
https://doi.org/10.1074/jbc.m211185200
https://doi.org/10.1074/jbc.m211185200
Publikováno v:
Journal of Laboratory and Clinical Medicine. 129:208-216
We examined the effects of thrombospondin-1 (TSP1) and thrombospondin-2 (TSP2) on the uptake of tritiated thymidine by bovine aortic endothelial (BAE) cells in response to two growth factors, basic fibroblast growth factor (bFGF) and lysophosphatidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560eb92892c448f6f0198d61f1904b1b
https://doi.org/10.1016/s0022-2143(97)90141-4
https://doi.org/10.1016/s0022-2143(97)90141-4
Autor:
Hui Chen, Joanne E. Murphy-Ullrich, David D. Roberts, Tina M. Misenheimer, Stacey Schultz-Cherry, Deane F. Mosher, Henry C. Krutzsch
Publikováno v:
Journal of Biological Chemistry. 270:7304-7310
Transforming growth factor-beta (TGF-beta) is a potent growth regulatory protein secreted by virtually all cells in a latent form. A major mechanism of regulating TGF-beta activity occurs through factors that control the processing of the latent to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac84c6fb78858b3061fc1c041d46301
https://doi.org/10.1074/jbc.270.13.7304
https://doi.org/10.1074/jbc.270.13.7304