Zobrazeno 1 - 10
of 19
pro vyhledávání: '"A M, LeDay"'
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 579:22-36
The eye is a unique organ because of its constant exposure to radiation, atmospheric oxygen, environmental chemicals and physical abrasion. That oxidative stress mechanisms in ocular tissues have been hypothesized to play a role in diseases such as g
Autor:
Sunny E. Ohia, Lydia C. Harris, Alekha K. Dash, Kaustubh H. Kulkarni, Angela M. LeDay, Catherine A. Opere, Sunday O. Awe
Publikováno v:
Neurochemical Research. 29:811-818
In the present study, we investigated the effect of naturally occurring and synthetic peroxides on K+-depolarization-evoked release of [3H]D-aspartate from bovine isolated retinae. Furthermore, effect of peroxides on endogenous glutamate concentratio
Autor:
Angela M. LeDay, Lydia C. Harris, Najam A. Sharif, S. Olubusayo Awe, Sunny E. Ohia, Kaustubh H. Kulkarni, Catherine A. Opere
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 19:599-609
The glucose deprivation-induced release of [3H]D-aspartate was studied in bovine and human retinas in a superfusion apparatus. [3H]D-aspartate release was significantly increased upon omitting glucose in the superfusion buffer. This effect was depend
Autor:
Lydia C. Harris, Sunny E. Ohia, Catherine A. Opere, Najam A. Sharif, S. Olubusayo Awe, Angela M. LeDay
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 18:339-348
The pharmacology of prejunctional serotonin (5-HT) heteroreceptors that regulate the release of norepinephrine (NE) was studied in isolated bovine and human iris-ciliary bodies. The effect of exogenous 5-HT and various 5-HT receptor agonists was exam
Autor:
Catherine A. Opere, Debasis Bagchi, Sidney J. Stohs, Angela M. LeDay, Sunny E. Ohia, Manashi Bagchi
Publikováno v:
Molecular and Cellular Biochemistry. 238:89-103
A growing body of evidence demonstrates the efficacy of Garcinia cambogia-derived natural (-)-hydroxycitric acid (HCA) in weight management by curbing appetite and inhibiting body fat biosynthesis. However, the exact mechanism of action of this novel
Autor:
Lydia C. Harris, Angela M. LeDay, Najam A. Sharif, Sunny E. Ohia, S. Olubusayo Awe, Catherine A. Opere
Publikováno v:
Experimental Eye Research. 73:59-67
In the present study, we investigated the pharmacological characteristics of electrically stimulated [3H]-serotonin release from mammalian iris-ciliary bodies. Isolated bovine and human iris-ciliary bodies were loaded with [3H]-serotonin, superfused
Autor:
Angela M. LeDay, Najam A. Sharif, S. Olubusayo Awe, Catherine A. Opere, Lydia C. Harris, Sunny E. Ohia
Publikováno v:
Current Eye Research. 23:386-392
The aim of the present study was two-fold: (a) to examine the effect of hypoxia on [(3)H]D-aspartate release from isolated bovine and human retinae, and (b) to investigate the regulation of hypoxia-induced neurotransmitter release by glutamate recept
Publikováno v:
Free Radical Research. 35:257-264
Isoprostanes (IsoP) are formed by free radical catalyzed peroxidation of arachidonic acid independent of the cyclooxygenase enzyme. In the present study, we examined the effect of IsoP on norepinephrine (NE) release from the bovine isolated iris. Fur
Autor:
Jennifer Graham, Gretel Ramos, S. Olubusayo Awe, Lydia C. Harris, Sunny E. Ohia, Justin C. Rice, Angela M. LeDay, Catherine A. Opere
Publikováno v:
Neurochemical Research. 25:519-525
In the present study, we investigated the effect of inhibition of cyclooxygenase (COX) with flurbiprofen (FBF) on peroxide-induced enhancement of field-stimulated [3H]norepinephrine ([3H]NE) release from bovine isolated irides. Furthermore, the effec
Autor:
Ghislaine Kouamou, Catherine A. Opere, Ya Fatou Njie-Mbye, Angela M. LeDay, Emmanuel Monjok, Sunny E. Ohia
Publikováno v:
Current eye research. 35(5)
To investigate the direct pharmacological actions of L-cysteine, a substrate for the production of H(2)S, on isolated porcine irides in the presence of tone induced by muscarinic receptor stimulation. Furthermore, we examined the underlying mechanism