Zobrazeno 1 - 10
of 27
pro vyhledávání: '"A M, LUH"'
Autor:
Katrin Juenemann, Ulrike Scheib, Michael Brands, Philipp M. Cromm, Laura M. Luh, Lars Wortmann
Publikováno v:
Angewandte Chemie. 132:15576-15595
Autor:
Katrin Juenemann, Ulrike Scheib, Laura M. Luh, Philipp M. Cromm, Lars Wortmann, Michael Brands
Publikováno v:
Angewandte Chemie (International Ed. in English)
Targeted protein degradation (TPD), the ability to control a proteins fate by triggering its degradation in a highly selective and effective manner, has created tremendous excitement in chemical biology and drug discovery within the past decades. The
Autor:
Laura M. Luh, Anne Bertolotti
Publikováno v:
Current Opinion in Neurobiology. 61:125-132
The deposition of proteins of abnormal conformation is one of the major hallmarks of the common neurodegenerative diseases including Alzheimer's, Parkinson's, amyotrophic lateral sclerosis, frontotemporal dementia, and prion diseases. Protein quality
Publikováno v:
Drug discovery today. Technologies. 37
Small molecule induced protein degradation has created tremendous excitement in drug discovery within recent years. Not being confined to target inhibition and being able to remove disease-causing protein targets via engagement and subsequent ubiquit
Autor:
Naomi Barak, Atanas Kamburov, Nina Zablowsky, Laura M. Luh, Hanna Meyer, Uwe Eberspächer, Martin Lange, Jérémie Mortier, Clara Lemos, Nico Braeuer, Thomas Markus Leissing, Patrick Steigemann, Joerg Weiske, Ralf Lesche, Michael Steckel, Holger Steuber, Carlo Stresemann, Nicolas Werbeck, Ashley Eheim, Luise Schulze, Katrin Juenemann, Knut Eis
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101517-(2020)
iScience
iScience
Summary Structural mutants of p53 induce global p53 protein destabilization and misfolding, followed by p53 protein aggregation. First evidence indicates that p53 can be part of protein condensates and that p53 aggregation potentially transitions thr
Autor:
Annika Weber, Maximillian M. Dalglish, Jörg Morf, Kim Schneider, Laura M. Luh, Anne Bertolotti, Geoffrey M. Nelson, Joseph L. Watson
Publikováno v:
Cell Reports
Summary Phosphorylation of the translation initiation factor eIF2α is a rapid and vital response to many forms of stress, including protein-misfolding stress in the endoplasmic reticulum (ER stress). It is believed to cause a general reduction in pr
Autor:
Changli Wang, Zhenfa Zhang, Etienne Giroux-Leprieur, Juanjuan Che, David M. Jablons, Gavitt A. Woodard, Thomas M. Luh, Hui Li, Lei Wang, Min-Li Mo, Dongsheng Yue, Xishan Hao, Biao He, Yong Zhou, Joy Q. Jin, Bhairavi Tolani, Zhao Chen
Publikováno v:
Oncotarget, vol 7, iss 49
Oncotarget
Oncotarget
// Hui Li 1, * , Dongsheng Yue 1, 2, * , Joy Q. Jin 1 , Gavitt A. Woodard 1 , Bhairavi Tolani 1 , Thomas M. Luh 1 , Etienne Giroux-Leprieur 1 , Minli Mo 3 , Zhao Chen 3 , Juanjuan Che 4 , Zhenfa Zhang 2 , Yong Zhou 1 , Lei Wang 1, 5 , Xishan Hao 2 ,
Publikováno v:
Nature Protocols. 12:1451-1457
Phenotypic analysis of mouse models of human diseases is essential to understand the underlying disease mechanisms and to develop therapeutics. Many models of neurodegenerative diseases are associated with motor dysfunction, a powerful readout for th
Autor:
Laura M. Luh, Florian R. Greten, Christian Behrends, Francesca Gioia Klinger, Sebastian Kehrloesser, Massimo De Felici, Stefan Knapp, Valerio Rossi, Alexander Strubel, Katharina Hötte, Ernst H. K. Stelzer, D. Coutandin, Marcel Tuppi, Birgit Schäfer, Volker Dötsch, Tiago De Oliveira, Meike Hoffmeister
Publikováno v:
Nature structuralmolecular biology. 25(3)
The survival rate of cancer patients is steadily increasing, owing to more efficient therapies. Understanding the molecular mechanisms of chemotherapy-induced premature ovarian insufficiency (POI) could identify targets for prevention of POI. Loss of
Autor:
William E. Benitz, Rajesh Punn, Thomas M. Luh, Jonathan P. Palma, Norman H. Silverman, Shabnam Gaskari, Veena V. Goel, Nichole A. Wang, Valerie Y. Chock
Publikováno v:
American journal of perinatology. 34(10)
Objective This historical cohort study investigated how a shift toward a more conservative approach of awaiting spontaneous closure of the patent ductus arteriosus (PDA) in preterm infants has affected neonatal outcomes and resource utilization. Meth