Zobrazeno 1 - 10
of 619
pro vyhledávání: '"A M, Katzin"'
Autor:
Rodrigo A. C. Sussmann, Heloisa B. Gabriel, Alejandro García Ríos, Danielle S. Menchaca Vega, Lydia F. Yamaguchi, Antonio Doménech-Carbó, Gerardo Cebrián-Torrejón, Emilia A. Kimura, Massuo J. Kato, Ignasi Bofill Verdaguer, Marcell Crispim, Alejandro M. Katzin
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Malaria is one of the most widespread parasitic diseases, especially in Africa, Southeast Asia and South America. One of the greatest problems for control of the disease is the emergence of drug resistance, which leads to a need for the development o
Externí odkaz:
https://doaj.org/article/a2a0c61706c245b08503bdbba258f959
Autor:
José Mário F. Balanco, Rodrigo A.C. Sussmann, Ignasi B. Verdaguer, Heloisa B. Gabriel, Emilia A. Kimura, Alejandro M. Katzin
Publikováno v:
FEBS Open Bio, Vol 9, Iss 4, Pp 743-754 (2019)
Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus Leishmania. Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug‐resistant strains has been observed. Therefore, new therapeutic ta
Externí odkaz:
https://doaj.org/article/bfe0ccad99dc4d97b870c7ac949f815d
Autor:
Sullivan, Elizabeth K.
Publikováno v:
The American Journal of Nursing, 1956 Oct 01. 56(10), 1333-1334.
Externí odkaz:
https://www.jstor.org/stable/3461189
Autor:
Valeska S. de Sena Pereira, Flávio da Silva Emery, Lis Lobo, Fátima Nogueira, Jonas I. N. Oliveira, Umberto L. Fulco, Eudenilson L. Albuquerque, Alejandro M. Katzin, Valter F. de Andrade-Neto
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-11 (2018)
Abstract Background Plasmodium falciparum has shown multidrug resistance, leading to the necessity for the development of new drugs with novel targets, such as the synthesis of isoprenic precursors, which are excellent targets because the pathway is
Externí odkaz:
https://doaj.org/article/af877e10390245d8b11e827d55bcac82
Publikováno v:
Parasites & Vectors, Vol 10, Iss 1, Pp 1-8 (2017)
Abstract Background Plasmodium falciparum is sensitive to oxidative stress in vitro and in vivo, and many drugs such as artemisinin, chloroquine and cercosporin interfere in the parasite’s redox system. To minimize the damage caused by reactive rad
Externí odkaz:
https://doaj.org/article/5dd8a8e69c4f4abb8e8242e0191eaa53
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 113, Iss 10 (2018)
Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we s
Externí odkaz:
https://doaj.org/article/070f78d6ac6e47c78c42ae26b0270cfd
Autor:
Ignasi B. Verdaguer, Camila A. Zafra, Marcell Crispim, Rodrigo A.C. Sussmann, Emília A. Kimura, Alejandro M. Katzin
Publikováno v:
Molecules, Vol 24, Iss 20, p 3721 (2019)
Human parasitic protozoa cause a large number of diseases worldwide and, for some of these diseases, there are no effective treatments to date, and drug resistance has been observed. For these reasons, the discovery of new etiological treatments is n
Externí odkaz:
https://doaj.org/article/0dbeb65581104fa2a014868aa60ea417
Autor:
María B Cassera, Emilio F Merino, Valnice J Peres, Emilia A Kimura, Gerhard Wunderlich, Alejandro M Katzin
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 102, Iss 3, Pp 377-384 (2007)
In Plasmodium falciparum, the formation of isopentenyl diphosphate and dimethylallyl diphosphate, central intermediates in the biosynthesis of isoprenoids, occurs via the methylerythritol phosphate (MEP) pathway. Fosmidomycin is a specific inhibitor
Externí odkaz:
https://doaj.org/article/b7f069bcfde046a0946a99f0f209621b
Autor:
Rodrigo A.C. Sussmann, Heloisa B. Gabriel, J M F Balanco, Ignasi Bofill Verdaguer, Emilia A. Kimura, Alejandro M. Katzin
Publikováno v:
FEBS Open Bio
Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus Leishmania. Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug-resistant strains has been observed. Therefore, new therapeutic targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48eeff7de698bfb0d03dfb6a422f8afe
http://europepmc.org/articles/PMC6443866
http://europepmc.org/articles/PMC6443866
Autor:
Rodrigo A.C. Sussmann, Fernando G. de Almeida, Mauro F Azevedo, Emilia A. Kimura, H R Melo, Marcell Crispim, C A Zafra, Ignasi Bofill Verdaguer, Alejandro M. Katzin, N L Buriticá
Publikováno v:
Antimicrob Agents Chemother
Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH(2)) for its union to the mitochondrial bc(1) complex, preventing the ubiquinone-8 and ubiquinone-9 (UQ-8 and UQ-9) redox recycling, which is a necessary step in pyrimidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be3ad2bf42c03fd69cd8aa66e00d376
https://doi.org/10.1128/aac.01516-20
https://doi.org/10.1128/aac.01516-20