Characterisation of mexiletine’s translational therapeutic index for suppression of ischaemia-induced ventricular fibrillation in the rat isolated heart

Autor: Catherine D. E. Wilder, Jade S. Munro, Michael J. Curtis, Nakita Ahdi, Georgia Lytra, Niraja N. Ranadive, Patrisia Qazimi, Louise M. Hesketh

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Hesketh, L M, Wilder, C D E, Ranadive, N N, Lytra, G, Qazimi, P, Munro, J S, Ahdi, N & Curtis, M J 2020, ' Characterisation of mexiletine’s translational therapeutic index for suppression of ischaemia-induced ventricular fibrillation in the rat isolated heart ', Scientific Reports, vol. 10, no. 1, 8397 . https://doi.org/10.1038/s41598-020-65190-y

The ‘translational therapeutic index’ (TTI) is a drug’s ratio of nonclinical threshold dose (or concentration) for significant benefit versus threshold for adversity. In early nonclinical research, discovery and safety studies are normally unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2705f1dff92706d8102bcd236492d25
https://doi.org/10.1038/s41598-020-65190-y

Comparative hepatitis A seroepidemiology in 10 European countries

Autor: Bianca Bruzzone, A. Hatzakis, Satu Kurkela, L. M. Hesketh, Adriana Pistol, Irja Davidkin, V. Nemecek, S. Caplinskas, N. Andrews, Cleo Anastassopoulou, George Kafatos, Anthony Nardone, Wiebke Hellenbrand, Richard Pebody, R. Vranckx, Z. Sobotová, C. Barbara, D. Butur

Publikováno v: Epidemiol Infect

SUMMARYThe WHO recommends hepatitis A virus (HAV) immunization according to level of transmission and disease burden. We aimed to identify susceptible age groups by standardized serosurveys to inform HAV vaccination policy in participating countries:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f36866545e5291301b4f7581923ee46
https://doi.org/10.1017/s0950268812000015

Estimating hepatitis C infection acquired in England, 1986–2000

Autor: L. M. Hesketh, John Parry, George Kafatos, M. A. Balogun, Mary Ramsay, A. J. Vyse

Publikováno v: Epidemiology and Infection. 137:1249-1254

SUMMARYHepatitis C is a global health problem and in the UK seroprevalence studies have mainly concentrated on specific high-risk groups. The aim of this study was to determine changes in the prevalence of antibody to hepatitis C virus in England usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a06cdeca6800b124391dc6939baa4fc
https://doi.org/10.1017/s0950268809002143

Interpreting serological surveys using mixture models: the seroepidemiology of measles, mumps and rubella in England and Wales at the beginning of the 21st century

Autor: A. J. VYSE, N. J. GAY, L. M. HESKETH, R. PEBODY, P. MORGAN-CAPNER, E. MILLER

Publikováno v: Epidemiology and Infection. 134:1303-1312

A mixture modelling technique is applied to age-specific frequency distributions of quantitative results from serological surveys for measles, mumps and rubella using samples collected across the age range in England and Wales in 2000. In accordance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f720b16b4c930d36ceb325aa2d82691
https://doi.org/10.1017/s0950268806006340

Sero-epidemiological patterns of epstein-barr and herpes simplex (HSV-1 and HSV-2) viruses in England and Wales

Autor: Marianne C. Morris, Louise M. Hesketh, Elizabeth Miller, David W. Brown, A. J. Vyse, P. Morgan-Capner, W. John Edmunds

Publikováno v: Journal of Medical Virology. 67:522-527

The aim was to carry out a population-based sero-prevalence survey of Epstein-Barr virus (EBV) across a wide age range in England and Wales and to identify any associations between EBV and herpes simplex virus types one and two (HSV-1 and 2). Sera fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f092197ca9f22e4e4a3fdeb96c2fd1f7
https://doi.org/10.1002/jmv.10132