Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci.

Autor: Anu Pasanen, Minna K Karjalainen, FinnGen, Ge Zhang, Heli Tiensuu, Antti M Haapalainen, Marja Ojaniemi, Bjarke Feenstra, Bo Jacobsson, Aarno Palotie, Hannele Laivuori, Louis J Muglia, Mika Rämet, Mikko Hallman

Publikováno v: PLoS Genetics, Vol 19, Iss 10, p e1010982 (2023)

BackgroundPreterm birth (MethodsWe conducted a genome-wide meta-analysis of gestational duration and spontaneous preterm birth in 68,732 and 98,370 European mothers, respectively.ResultsThe meta-analysis detected 15 loci associated with gestational d

Externí odkaz: https://doaj.org/article/f14300073a8b497a870ffbbe353c0e10

Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth

Autor: Johanna M. Huusko, Heli Tiensuu, Antti M. Haapalainen, Anu Pasanen, Pinja Tissarinen, Minna K. Karjalainen, Ge Zhang, Kaare Christensen, Kelli K. Ryckman, Bo Jacobsson, Jeffrey C. Murray, Stephen F. Kingsmore, Mikko Hallman, Louis J. Muglia, Mika Rämet

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Heat shock proteins are involved in the response to stress including activation of the immune response. Elevated circulating heat shock proteins are associated with spontaneous preterm birth (SPTB). Intracellular heat shock proteins act as m

Externí odkaz: https://doaj.org/article/f305df8cd6b34e51b15c496289d931fa

Risk of spontaneous preterm birth and fetal growth associates with fetal SLIT2.

Autor: Heli Tiensuu, Antti M Haapalainen, Minna K Karjalainen, Anu Pasanen, Johanna M Huusko, Riitta Marttila, Marja Ojaniemi, Louis J Muglia, Mikko Hallman, Mika Rämet

Publikováno v: PLoS Genetics, Vol 15, Iss 6, p e1008107 (2019)

Spontaneous preterm birth (SPTB) is the leading cause of neonatal death and morbidity worldwide. Both maternal and fetal genetic factors likely contribute to SPTB. We performed a genome-wide association study (GWAS) on a population of Finnish origin

Externí odkaz: https://doaj.org/article/40722b32dea848e9ab80e286121da752

Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth

Autor: Jeffrey C. Murray, Kaare Christensen, Johanna M. Huusko, Ge Zhang, Mika Rämet, Antti M. Haapalainen, Anu Pasanen, Mikko Hallman, Minna K. Karjalainen, Bo Jacobsson, Pinja Tissarinen, Heli Tiensuu, Kelli K. Ryckman, Louis J. Muglia, Stephen F. Kingsmore

Publikováno v: Scientific Reports
Huusko, J M, Tiensuu, H, Haapalainen, A M, Pasanen, A, Tissarinen, P, Karjalainen, M K, Zhang, G, Christensen, K, Ryckman, K K, Jacobsson, B, Murray, J C, Kingsmore, S F, Hallman, M, Muglia, L J & Rämet, M 2021, ' Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth ', Scientific Reports, vol. 11, 17115 . https://doi.org/10.1038/s41598-021-96374-9
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Heat shock proteins are involved in the response to stress including activation of the immune response. Elevated circulating heat shock proteins are associated with spontaneous preterm birth (SPTB). Intracellular heat shock proteins act as multifunct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed011d2f316be5a08f0d88c3400f0a0b
https://hdl.handle.net/11250/2988984

CPPED1-targeting microRNA-371a-5p expression in human placenta associates with spontaneous delivery

Autor: Marja Ojaniemi, Antti M. Haapalainen, Mika Rämet, Ravindra Daddali, Mikko Hallman

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0234403 (2020)

MicroRNAs (miRNAs) are important regulators of gene expression, and their expression is associated with many physiological conditions. Here, we investigated potential associations between expression levels of miRNAs in human placenta and the onset of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8e80773568d7f80d79cd0a07c6b3ab
https://doi.org/10.1371/journal.pone.0234403