Zobrazeno 1 - 10
of 1 099
pro vyhledávání: '"A M, Glazer"'
Autor:
Ayesha Muhammad, Maria E. Calandranis, Bian Li, Tao Yang, Daniel J. Blackwell, M. Lorena Harvey, Jeremy E. Smith, Zerubabell A. Daniel, Ashli E. Chew, John A. Capra, Kenneth A. Matreyek, Douglas M. Fowler, Dan M. Roden, Andrew M. Glazer
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background KCNE1 encodes a 129-residue cardiac potassium channel (I Ks) subunit. KCNE1 variants are associated with long QT syndrome and atrial fibrillation. However, most variants have insufficient evidence of clinical consequences and thus
Externí odkaz:
https://doaj.org/article/b05f643c1f884a7dbcf19bfac871b67b
Autor:
Melina Claussnitzer, Victoria N. Parikh, Alex H. Wagner, Jeremy A. Arbesfeld, Carol J. Bult, Helen V. Firth, Lara A. Muffley, Alex N. Nguyen Ba, Kevin Riehle, Frederick P. Roth, Daniel Tabet, Benedetta Bolognesi, Andrew M. Glazer, Alan F. Rubin
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Multiplexed assays of variant effect (MAVEs) have emerged as a powerful approach for interrogating thousands of genetic variants in a single experiment. The flexibility and widespread adoption of these techniques across diverse disciplines h
Externí odkaz:
https://doaj.org/article/ee5b2abbc9bf4533aed98196fa9861b1
Autor:
Rachael Putman, Adele S. Ricciardi, Kelly E. W. Carufe, Elias Quijano, Raman Bahal, Peter M. Glazer, W. Mark Saltzman
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 3, Pp n/a-n/a (2023)
Abstract Through preimplantation genetic diagnosis, genetic diseases can be detected during the early stages of embryogenesis, but effective treatments for many of these disorders are lacking. Gene editing could allow for correction of the underlying
Externí odkaz:
https://doaj.org/article/3edcc4c4f2cd451898388383fe6988a7
Autor:
A. M. Glazer, Patience Thomson
Crystal Clear takes you behind the scenes in the life of one of the most prominent scientists of the twentieth century, William Lawrence Bragg (WLB) - an innovative genius, who together with his father, William Henry Bragg (WHB) founded and developed
Autor:
Yong-Li Dong, Gangadhara P. Vadla, Jin-Yu (Jim) Lu, Vakil Ahmad, Thomas J. Klein, Lu-Fang Liu, Peter M. Glazer, Tian Xu, Chiswili-Yves Chabu
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Dong, Vadla et al. find that oncogenic Ras and p53 cooperatively stimulate JAK/STAT cytokines to promote non-autonomous tissue overgrowth in Drosophila. Further, blocking STAT signalling prevents the growth-inducing effect of p53 overexpression and i
Externí odkaz:
https://doaj.org/article/eca0121cdb5c4fb8ac2dfcc338fcb5ed
Autor:
Chris M. Cassara, Micah T. Long, John T. Dollerschell, Floria Chae, David J. Hall, Gozde Demiralp, Matthew J. Stampfl, Brittney Bernardoni, Daniel P. McCarthy, Joshua M. Glazer
Publikováno v:
Medicina, Vol 58, Iss 12, p 1815 (2022)
The rates of survival with functional recovery for out of hospital cardiac arrest remain unacceptably low. Extracorporeal cardiopulmonary resuscitation (ECPR) quickly resolves the low-flow state of conventional cardiopulmonary resuscitation (CCPR) pr
Externí odkaz:
https://doaj.org/article/50ebb38b28794a26b78e430997f05ae3
Autor:
Kevin R. Bersell, Tao Yang, Jonathan D. Mosley, Andrew M. Glazer, Andrew T. Hale, Dmytro O. Kryshtal, Kyungsoo Kim, Jeffrey D. Steimle, Jonathan D. Brown, Joe-Elie Salem, Courtney C. Campbell, Charles C. Hong, Quinn S. Wells, Amanda N. Johnson, Laura Short, Marcia A. Blair, Elijah R. Behr, Evmorfia Petropoulou, Yalda Jamshidi, Mark D. Benson, Michelle J. Keyes, Debby Ngo, Ramachandran S. Vasan, Qiong Yang, Robert E. Gerszten, Christian Shaffer, Shan Parikh, Quanhu Sheng, Prince J. Kannankeril, Ivan P. Moskowitz, John D. York, Thomas J. Wang, Bjorn C. Knollmann, Dan M. Roden
Publikováno v:
Circulation. 147:824-840
Background: Brugada syndrome (BrS) is an inherited arrhythmia syndrome caused by loss-of-function variants in the cardiac sodium channel gene SCN5A (sodium voltage-gated channel alpha subunit 5) in ≈20% of subjects. We identified a family with 4 in
Publikováno v:
APL Materials, Vol 9, Iss 3, Pp 030702-030702-8 (2021)
PbZrO3-based antiferroelectric crystals are of great interest in both fundamental and applied research, not only because of the antiferroelectric feature at room temperature but also because of the existence of a peculiar intermediate state at ele
Externí odkaz:
https://doaj.org/article/18f956ba8f6f4272a0ca0e75194dfc86
Autor:
Alican Gulsevin, Andrew M. Glazer, Tiffany Shields, Brett M. Kroncke, Dan M. Roden, Jens Meiler
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2225 (2022)
The cardiac sodium ion channel (NaV1.5) is a protein with four domains (DI-DIV), each with six transmembrane segments. Its opening and subsequent inactivation results in the brief rapid influx of Na+ ions resulting in the depolarization of cardiomyoc
Externí odkaz:
https://doaj.org/article/847f3f6bac334da08828c78d359258f1
Autor:
Michael S. Pulia, Daniel J. Hekman, Joshua M. Glazer, Ciara Barclay-Buchanan, Nicholas Kuehnel, Joshua Ross, Brian Sharp, Robert Batt, Brian W. Patterson
Publikováno v:
Western Journal of Emergency Medicine, Vol 21, Iss 4 (2020)
Introduction: SARS-CoV-2, a novel coronavirus, manifests as a respiratory syndrome (COVID-19) and is the cause of an ongoing pandemic. The response to COVID-19 in the United States has been hampered by an overall lack of diagnostic testing capacity.
Externí odkaz:
https://doaj.org/article/b3f623ec24c140229bbc03174120cf7c