Výsledky vyhledávání - "A M, Gewirtz"

Nucleic Acid-Based, mRNA-Targeted Therapeutics for Hematologic Malignancies

Autor: Alan M. Gewirtz

Publikováno v: Innovative Leukemia and Lymphoma Therapy ISBN: 9780429114670
Innovative Leukemia and Lymphoma Therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f876a836f4da745e05e999802fd3bb2
https://doi.org/10.1201/9780429114670-13

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c-Myb and GATA-3 Cooperatively Regulate IL-13 Expression via Conserved GATA-3 Response Element and Recruit Mixed Lineage Leukemia (MLL) for Histone Modification of the IL-13 Locus

Autor: Yuji Nakata, Teruhiko Kozuka, Mayumi Sugita, Susan E. Shetzline, Alan M. Gewirtz

Publikováno v: The Journal of Immunology. 187:5974-5982

The c-Myb and GATA-3 transcription factors play important roles in T cell development. We recently reported that c-Myb, GATA-3, and Menin form a core transcription complex that regulates GATA-3 expression and ultimately Th2 cell development in human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205db63d29bdab35c7b1ca80ea987a21
https://doi.org/10.4049/jimmunol.1100550

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c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development

Autor: Anne Brignier, Stephen I. Rudnick, Mayumi Sugita, Yuan Shen, Alan M. Gewirtz, Yuji Nakata, Shenghao Jin

Publikováno v: Blood. 116:1280-1290

GATA-3 and c-Myb are core elements of a transcriptionally active complex essential for human Th2 cell development and maintenance. We report herein mechanistic details concerning the role of these transcription factors in human peripheral blood Th2 c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10356e79c67faeab3b6b30778440516
https://doi.org/10.1182/blood-2009-05-223255

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c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis

Autor: Alan M. Gewirtz, Yuji Nakata, Huiwu Zhao, Anna Kalota, Yan Yi, Shenghao Jin

Publikováno v: Journal of Clinical Investigation. 120:593-606

Mixed-lineage leukemia (MLL) is a proto-oncogene frequently involved in chromosomal translocations associated with acute leukemia. These chromosomal translocations commonly result in MLL fusion proteins that dysregulate transcription. Recent data sug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb51c82e4b13890d5b045ba5e42d3694
https://doi.org/10.1172/jci38030

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A prototype nonpeptidyl, hydrazone class, thrombopoietin receptor agonist, SB-559457, is toxic to primary human myeloid leukemia cells

Autor: Anna Kalota, Alan M. Gewirtz

Publikováno v: Blood. 115:89-93

Biologic characterization of SB-559457 (SB), a nonpeptidyl hydrazone class of thrombopoietin receptor (Mpl) agonist, revealed toxicity toward human leukemia cells. Antiproliferative effects followed by significant, nonapoptotic, cell death within 72

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd7a9887fc9bf02ed1375ce17f2d42a
https://doi.org/10.1182/blood-2009-06-227751

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A Phase I Study of the Mammalian Target of Rapamycin Inhibitor Sirolimus and MEC Chemotherapy in Relapsed and Refractory Acute Myelogenous Leukemia

Autor: Stephen J. Schuster, Dan T. Vogl, Noelle V. Frey, Alan M. Gewirtz, Adam Bagg, Elizabeth O. Hexner, Selina M. Luger, Margaret Kasner, Sunita D. Nasta, Donald E. Tsai, Jamil Dierov, Cezary R. Swider, David L. Porter, Steven C. Goldstein, Alison W. Loren, Martin Carroll, Alexander E. Perl, Edward A. Stadtmauer

Publikováno v: Clinical Cancer Research. 15:6732-6739

Purpose: Inhibiting mammalian target of rapamycin (mTOR) signaling in acute myelogenous leukemia (AML) blasts and leukemic stem cells may enhance their sensitivity to cytotoxic agents. We sought to determine the safety and describe the toxicity of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202640c5e01601eb37b32729ab508eb1
https://doi.org/10.1158/1078-0432.ccr-09-0842

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Effects of local mRNA structure on posttranscriptional gene silencing

Autor: Stephen A. Liebhaber, Marina Sumaroka, Jyothishmathi Swaminathan, Alan M. Gewirtz, Stephen I. Rudnick

Publikováno v: Proceedings of the National Academy of Sciences. 105:13787-13792

Antisense oligodeoxynucleotides (AONs) and short interfering RNAs (siRNAs) effect posttranscriptional gene silencing (PTGS) by hybridizing to an mRNA and then directing its cleavage. To understand the constraints that mRNA structure imposes on AON- v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195a0aa5f53d29e9393735d462003694
https://doi.org/10.1073/pnas.0805781105

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c-Myb Contributes to G2/M Cell Cycle Transition in Human Hematopoietic Cells by Direct Regulation of Cyclin B1 Expression

Autor: Yuji Nakata, Anna Kalota, Stephen I. Rudnick, Alan M. Gewirtz, Susan E. Shetzline, Stephen G. Emerson, Yi Zhang, Ravikumar Rallapalli, Chizuko Sakashita

Publikováno v: Molecular and Cellular Biology. 27:2048-2058

Myb family proteins are ubiquitously expressed transcription factors. In mammalian cells, they play a critical role in regulating the G(1)/S cell cycle transition but their role in regulating other cell cycle checkpoints is incompletely defined. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3366f1b648df1ff3296d6677a7cc43
https://doi.org/10.1128/mcb.01100-06

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