Zobrazeno 1 - 10 of 18 pro vyhledávání: '"A M, Chudzinski"'
1
Akademický článek
Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity
Autor: K. L. P. Morais, L. Ciccone, E. Stura, M. P. Alvarez-Flores, G. Mourier, M. Vanden Driessche, J. M. Sciani, A. Iqbal, S. P. Kalil, G. J. Pereira, R. Marques-Porto, P. Cunegundes, L. Juliano, D. Servent, A. M. Chudzinski-Tavassi
Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)
Amblyomin-X is a Kunitz-type FXa inhibitor identified through the transcriptome analysis of the salivary gland from Amblyomma sculptum tick. This protein consists of two domains of equivalent size, triggers apoptosis in different tumor cell lines, an
Externí odkaz: https://doaj.org/article/1dda03cd9dbb4ede84e2fbe8555f9a69
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2
Akademický článek
A Kunitz-type inhibitor from tick salivary glands: A promising novel antitumor drug candidate
Autor: Aline R. M. Lobba, Miryam Paola Alvarez-Flores, Melissa Regina Fessel, Marcus Vinicius Buri, Douglas S. Oliveira, Renata N. Gomes, Priscila S. Cunegundes, Carlos DeOcesano-Pereira, Victor D. Cinel, Ana M. Chudzinski-Tavassi
Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)
Salivary glands are vital structures responsible for successful tick feeding. The saliva of ticks contains numerous active molecules that participate in several physiological processes. A Kunitz-type factor Xa (FXa) inhibitor, similar to the tissue f
Externí odkaz: https://doaj.org/article/555884386be24d9ea33c4470bba4c752
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3
Akademický článek
Preclinical evaluation of Amblyomin-X, a Kunitz-type protease inhibitor with antitumor activity
Autor: Durvanei A. Maria, Sonia Elisabete A.L. Will, Rosemary V. Bosch, Jean G. Souza, Juliana M. Sciani, Mauricio B. Goldfeder, Giuliana G. Rondon, Ana M. Chudzinski-Tavassi
Publikováno v: Toxicology Reports, Vol 6, Iss , Pp 51-63 (2019)
Amblyomin-X, a Kunitz-type protease inhibitor, is a recombinant protein that selectively induces apoptosis in tumor cells and promotes tumor reduction in vivo in melanoma animal models. Furthermore, Amblyomin-X was able to drastically reduce lung met
Externí odkaz: https://doaj.org/article/10194f3bcbaf480f88ffcab08a20c7d6
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4
Akademický článek
rACLF, a recombinant snake venom metalloprotease, activates endothelial cells in vitro
Autor: C. K. De Moraes, M. Fritzen, A. M. Chudzinski-Tavassi, H. S. Selistre-de-Araújo
Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 14, Iss 1, Pp 113-127 (2008)
Snake venom metalloproteases (SVMPs) comprise a family of snake venom toxins responsible for most of local and systemic effects observed during envenomation by snakes from the Viperidae family. The vascular system and more specifically the endotheliu
Externí odkaz: https://doaj.org/article/ca80bbba3e974683a572c5fb1efcbf91
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5
Akademický článek
Biochemical and biological properties of Lonomia obliqua bristle extract
Autor: A. M. Chudzinski-Tavassi, L. C. Carrijo-Carvalho
Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 2, Pp 159-171 (2006)
Lonomia obliqua caterpillar is frequently seen in accidents with humans especially in the south of Brazil. Patients develop a hemorrhagic syndrome that can be treated with specific antilonomic serum. A consumptive coagulopathy was found to be the mai
Externí odkaz: https://doaj.org/article/0477e1256f7d474a8847b563230bc453
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6
Akademický článek
Dynein function and protein clearance changes in tumor cells induced by a Kunitz-type molecule, Amblyomin-X.
Autor: Mario T F Pacheco, Carolina M Berra, Kátia L P Morais, Juliana M Sciani, Vania G Branco, Rosemary V Bosch, Ana M Chudzinski-Tavassi
Publikováno v: PLoS ONE, Vol 9, Iss 12, p e111907 (2014)
Amblyomin-X is a Kunitz-type recombinant protein identified from the transcriptome of the salivary glands of the tick Amblyomma cajennense and has anti-coagulant and antitumoral activity. The supposed primary target of this molecule is the proteasome
Externí odkaz: https://doaj.org/article/575ef158a76a4f7e805b70e8407e3605
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7
Biochemical and biological properties of Lonomia obliqua bristle extract
Autor: L. C. Carrijo-Carvalho, A. M. Chudzinski-Tavassi
Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 2, Pp 159-171 (2006)
Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 12, Issue: 2, Pages: 159-171, Published: APR 2006
Journal of Venomous Animals and Toxins including Tropical Diseases v.12 n.2 2006
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Lonomia obliqua caterpillar is frequently seen in accidents with humans especially in the south of Brazil. Patients develop a hemorrhagic syndrome that can be treated with specific antilonomic serum. A consumptive coagulopathy was found to be the mai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6565f149d5fa615ec2ebd9d95b65250a
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000200002
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8
New insight into the mechanism of Lonomia obliqua envenoming: toxin involvement and molecular approach
Autor: M P, Alvarez Flores, M, Zannin, A M, Chudzinski-Tavassi
Publikováno v: Pathophysiology of haemostasis and thrombosis. 37(1)
Despite the nearly worldwide distribution of Lepidoptera, there are few species with clear documentation of adverse reactions in humans. Most syndromes caused by Lepidoptera are consequences of direct contact with the hairs or setae of caterpillars.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d733292e45ef7e53edb3f36b48baa60
https://pubmed.ncbi.nlm.nih.gov/20714126
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9
rACLF, a recombinant snake venom metalloprotease, activates endothelial cells in vitro
Autor: M. Fritzen, A. M. Chudzinski-Tavassi, C. K. De Moraes, Heloisa S. Selistre-de-Araujo
Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases v.14 n.1 2008
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 14, Issue: 1, Pages: 113-127, Published: 2008
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 14, Iss 1, Pp 113-127 (2008)
Snake venom metalloproteases (SVMPs) comprise a family of snake venom toxins responsible for most of local and systemic effects observed during envenomation by snakes from the Viperidae family. The vascular system and more specifically the endotheliu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ef3d82baf607b6bd3eede839ceddb0
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000100009
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10
Studies on Blood Coagulation and Fibrinolysis in Patients Bitten by Bothrops jararaca (jararaca)
Autor: M Maruyama, Aura S Kamiguti, J L C Cardoso, Ida S Sano-Martins, Ana M Chudzinski, M L Santoro, P Morena, Sandra C Tomy, Luci C Antonia, H Mihara, Eva M A Kelen
Publikováno v: Thrombosis and Haemostasis. 63:449-453
SummaryThe blood coagulation and the fibrinolytic systems of nine patients envenomed by Bothrops jararaca in São Paulo (Brazil) were studied. Five of the accidents were caused by young snakes (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8003da28eb3e58bff658fc143a59863b
https://doi.org/10.1055/s-0038-1645064
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