Zobrazeno 1 - 10
of 1 624
pro vyhledávání: '"A M, Chinnaiyan"'
Autor:
Steven Kregel, Chao Wang, Xin Han, Lanbo Xiao, Ester Fernandez-Salas, Pushpinder Bawa, Brooke L. McCollum, Kari Wilder-Romans, Ingrid J. Apel, Xuhong Cao, Corey Speers, Shaomeng Wang, Arul M. Chinnaiyan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101064- (2024)
Externí odkaz:
https://doaj.org/article/0862d758f7f1496994a5fd8a9d33c95b
Autor:
Jae Eun Choi, Yuanyuan Qiao, Ilona Kryczek, Jiali Yu, Jonathan Gurkan, Yi Bao, Mahnoor Gondal, Jean Ching-Yi Tien, Tomasz Maj, Sahr Yazdani, Abhijit Parolia, Houjun Xia, JiaJia Zhou, Shuang Wei, Sara Grove, Linda Vatan, Heng Lin, Gaopeng Li, Yang Zheng, Yuping Zhang, Xuhong Cao, Fengyun Su, Rui Wang, Tongchen He, Marcin Cieslik, Michael D. Green, Weiping Zou, Arul M. Chinnaiyan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cancer treatment continues to shift from utilizing traditional therapies to targeted ones, such as protein kinase inhibitors and immunotherapy. Mobilizing dendritic cells (DC) and other myeloid cells with antigen presenting and cancer cell k
Externí odkaz:
https://doaj.org/article/110a46dd843f458b99af5d4a3c335b08
Autor:
Udit Singhal, Srinivas Nallandhighal, Jeffrey J. Tosoian, Kevin Hu, Trinh M. Pham, Judith Stangl-Kremser, Chia-Jen Liu, Razeen Karim, Komal R. Plouffe, Todd M. Morgan, Marcin Cieslik, Roberta Lucianò, Shahrokh F. Shariat, Nadia Finocchio, Lucia Dambrosio, Claudio Doglioni, Arul M. Chinnaiyan, Scott A. Tomlins, Alberto Briganti, Ganesh S. Palapattu, Aaron M. Udager, Simpa S. Salami
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Localized prostate cancer is frequently composed of multiple spatially distinct tumors with significant inter- and intra-tumoral molecular heterogeneity. This genomic diversity gives rise to many competing clones that may drive the biologica
Externí odkaz:
https://doaj.org/article/62b4741b814f4ceeb89934d4333d96c5
Autor:
Jae Eun Choi, Monique E. Verhaegen, Sahr Yazdani, Rohit Malik, Paul W. Harms, Doris Mangelberger, Jean Tien, Xuhong Cao, Yuping Wang, Marcin Cieślik, Jonathan Gurkan, Mishaal Yazdani, Xiaojun Jing, Kristin Juckette, Fengyun Su, Rui Wang, Bing Zhou, Ingrid J. Apel, Shaomeng Wang, Andrzej A. Dlugosz, Arul M. Chinnaiyan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 55, Iss , Pp 101019- (2024)
Externí odkaz:
https://doaj.org/article/24f5817d471d45d98d05c47b12f71a02
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Rapid advancements in high-throughput single-cell RNA-seq (scRNA-seq) technologies and experimental protocols have led to the generation of vast amounts of transcriptomic data that populates several online databases and repositories. Here, we systema
Externí odkaz:
https://doaj.org/article/43bc2c481c3141f5864cbec92ea63a55
Autor:
Reyaz ur Rasool, Caitlin M. O’Connor, Chandan Kanta Das, Mohammed Alhusayan, Brijesh Kumar Verma, Sehbanul Islam, Ingrid E. Frohner, Qu Deng, Erick Mitchell-Velasquez, Jaya Sangodkar, Aqila Ahmed, Sarah Linauer, Ingrid Mudrak, Jessica Rainey, Kaitlin P. Zawacki, Tahra K. Suhan, Catherine G. Callahan, Ryan Rebernick, Ramakrishnan Natesan, Javed Siddiqui, Guido Sauter, Dafydd Thomas, Shaomeng Wang, Derek J. Taylor, Ronald Simon, Marcin Cieslik, Arul M. Chinnaiyan, Luca Busino, Egon Ogris, Goutham Narla, Irfan A. Asangani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Loss of the tumor suppressive activity of the protein phosphatase 2A (PP2A) is associated with cancer, but the underlying molecular mechanisms are unclear. PP2A holoenzyme comprises a heterodimeric core, a scaffolding A subunit and a catalyt
Externí odkaz:
https://doaj.org/article/7ea3b219c8a941b89ece9e99f3bc0149
Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways
Autor:
Matthew Pun, Drew Pratt, Patricia R. Nano, Piyush K. Joshi, Li Jiang, Bernhard Englinger, Arvind Rao, Marcin Cieslik, Arul M. Chinnaiyan, Kenneth Aldape, Stefan Pfister, Mariella G. Filbin, Aparna Bhaduri, Sriram Venneti
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Globally decreased histone 3, lysine 27 tri-methylation (H3K27me3) is a hallmark of H3K27-altered diffuse midline gliomas (DMGs) and group-A posterior fossa ependymomas (PFAs). H3K27-altered DMGs are largely characterized by lysine-to-methio
Externí odkaz:
https://doaj.org/article/321f01c2cef0476ebdbcaea7e4469b04
Autor:
Anbarasu Kumaraswamy, Zhi Duan, Diana Flores, Chao Zhang, Archana Sehrawat, Ya-Mei Hu, Olivia A. Swaim, Eva Rodansky, William K. Storck, Joshua A. Kuleape, Karan Bedi, Rahul Mannan, Xiao-Ming Wang, Aaron Udager, Visweswaran Ravikumar, Armand Bankhead III, Ilsa Coleman, John K. Lee, Colm Morrissey, Peter S. Nelson, Arul M. Chinnaiyan, Arvind Rao, Zheng Xia, Joel A. Yates, Joshi J. Alumkal
Publikováno v:
JCI Insight, Vol 8, Iss 15 (2023)
Lysine-specific demethylase 1 (LSD1) is a histone demethylase that promotes stemness and cell survival in cancers such as prostate cancer. Most prostate malignancies are adenocarcinomas with luminal differentiation. However, some tumors undergo cellu
Externí odkaz:
https://doaj.org/article/e4a07a2910524a9eab732b3ab8ace38b
Autor:
Chandan Kumar-Sinha, Pankaj Vats, Nguyen Tran, Dan R. Robinson, Valerie Gunchick, Yi-Mi Wu, Xuhong Cao, Yu Ning, Rui Wang, Erica Rabban, Janice Bell, Sunita Shankar, Rahul Mannan, Yuping Zhang, Mark M. Zalupski, Arul M. Chinnaiyan, Vaibhav Sahai
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 42, Iss , Pp 100910- (2023)
Background: Biliary tract cancers (BTCs) including intrahepatic, perihilar, and distal cholangiocarcinoma as well as gallbladder cancer, are rare but aggressive malignancies with few effective standard of care therapies. Methods: We implemented integ
Externí odkaz:
https://doaj.org/article/267f07005d4148529c8e940f763e1135
Autor:
Indranill Basu-Ray, Kashinath Metri, Dibbendhu Khanra, Rishab Revankar, Kavitha M. Chinnaiyan, Nagaratna Raghuram, Mahesh Chandra Mishra, Bhushan Patwardhan, Manjunath Sharma, Ishwar V. Basavaraddi, Akshay Anand, Shrinath Reddy, K. K. Deepak, Marian Levy, Sue Theus, Glenn N. Levine, Holger Cramer, Gregory L. Fricchione, Nagendra R. Hongasandra
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background The ongoing novel coronavirus disease 2019 (COVID-19) pandemic has a significant mortality rate of 3–5%. The principal causes of multiorgan failure and death are cytokine release syndrome and immune dysfunction. Stress, anxiety,
Externí odkaz:
https://doaj.org/article/2157610a434a4c358898657fa52d3c1a