Zobrazeno 1 - 2
of 2
pro vyhledávání: '"A M, Campeta"'
Autor:
R P, Robinson, L A, Reiter, W E, Barth, A M, Campeta, K, Cooper, B J, Cronin, R, Destito, K M, Donahue, F C, Falkner, E F, Fiese, D L, Johnson, A V, Kuperman, T E, Liston, D, Malloy, J J, Martin, D Y, Mitchell, F W, Rusek, S L, Shamblin, C F, Wright
Publikováno v:
Journal of Medicinal Chemistry. 39:10-18
Ether, ester, and carbonate derivatives of the antirheumatic oxindole 1 were prepared and screened as potential prodrugs of 1. This effort led to the discovery of the (alpha-L-alanyloxy)-methyl ether and hemifumarate derivatives of 1 which deliver th
Autor:
Philip A, Carpino, Bruce A, Lefker, Steven M, Toler, Lydia C, Pan, John R, Hadcock, Ewell R, Cook, Joseph N, DiBrino, Anthony M, Campeta, Shari L, DeNinno, Kristin L, Chidsey-Frink, William A, Hada, John, Inthavongsay, F Michael, Mangano, Michelle A, Mullins, David F, Nickerson, Oicheng, Ng, Christine M, Pirie, John A, Ragan, Colin R, Rose, David A, Tess, Ann S, Wright, Li, Yu, Michael P, Zawistoski, Paul A, DaSilva-Jardine, Theresa C, Wilson, David D, Thompson
Publikováno v:
Bioorganicmedicinal chemistry. 11(4)
Novel pyrazolinone-piperidine dipeptide derivatives were synthesized and evaluated as growth hormone secretagogues (GHSs). Two analogues, capromorelin (5, CP-424391-18, hGHS-R1a K(i)=7 nM, rat pituicyte EC(50)=3 nM) and the des-methyl analogue 5c (hG