Zobrazeno 1 - 10
of 142
pro vyhledávání: '"A M, Beebe"'
Autor:
David Rosen, Laurence Fayadat-Dilman, Yiwei Zhang, Konstantin Dobrenkov, Elliot Chartash, Richard Wnek, Smita Mauze, Hans van Eenennaam, Judith Stammen-Vogelzangs, Ying Yu, Marco Guadagnoli, Lars Guelen, Thierry O Fischmann, Jerelyn Wong, Nikolina Bąbała, Jozef Wagenaars, Veronica Juan, Winnie Prosise, Maurice Habraken, Imke Lodewijks, Danling Gu, Jeanne Baker, David Lutje Hulsik, Lilian Driessen-Engels, Dan Malashock, Joost Kreijtz, Astrid Bertens, Evert de Vries, Astrid Bovens, Arne Bramer, Sean Troth, Svetlana Sadekova, Andrea van Elsas, Jason K Cheung, Jannie Borst, Amy M Beebe
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Immune checkpoint inhibitors (ICI) have radically changed cancer therapy, but most patients with cancer are unresponsive or relapse after treatment. MK-5890 is a CD27 agonist antibody intended to complement ICI therapy. CD27 is a member of
Externí odkaz:
https://doaj.org/article/cc59fd0a12e04837b4168ce751ae8a2b
Autor:
Jeremy M. Beebe, Dongchan Ahn, Donald V. Eldred, Alyssa J. Fielitz, Tyler R. Heyl, Myoungbae Lee, Shane Mangold, Eric Z. Pearce, Carl W. Reinhardt, Cheryl Roggenbuck, Justin M. Scherzer, Kenneth R. Shull, Anthony J. Silvaroli, Yu-Jing Tan, Muzhou Wang
Publikováno v:
Macromolecules. 55:5826-5839
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98234b6b2074adc1c2c37cb6654195a6
https://doi.org/10.1021/acs.macromol.2c00425
https://doi.org/10.1021/acs.macromol.2c00425
Autor:
Anthony J. Silvaroli, Tyler R. Heyl, Marius Chyasnavichyus, Jeremy M. Beebe, Dongchan Ahn, Shane Mangold, Qihua Chen, Muzhou Wang, Kenneth R. Shull
Publikováno v:
Macromolecules.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b5bad68da9ca16887f05d06f6e6b02e
https://doi.org/10.1021/acs.macromol.3c00466
https://doi.org/10.1021/acs.macromol.3c00466
Autor:
Renu Jain, Daniel J. Cua, Amy M. Beebe, Edward P. Bowman, Jane Xia, Barbara Joyce-Shaikh, Smita Mauze, Ashley E. Mahne
Agonistic monoclonal antibodies (mAb) targeting the T-cell receptor coregulatory molecule GITR exert potent therapeutic activities in preclinical tumor models. Although anti-GITR mAb are thought to act by depleting and destabilizing the intratumoral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981bd21ef7d17b20d8714f271ff1f6c8
https://doi.org/10.1158/0008-5472.c.6509418.v1
https://doi.org/10.1158/0008-5472.c.6509418.v1
Autor:
Svetlana Sadekova, Amy M. Beebe, Aarron Willingham, Terrill K. McClanahan, Danuta Herzyk, Wendy J. Bailey, Venkataraman Sriram, Elaine M. Pinheiro, Denise Manfra, Peter Georgiev, Ruban Mangadu, Tatyana Churakova, Jeff Grein, Antoaneta S. Necheva, Bhagyashree Bhagwat, Romina Riener, Grigori Ermakov, Saraswathi Naravula, Jerelyn Wong, Ying Yu, Douglas C. Wilson, Selvakumar Sukumar
Supplementary tables listing the affinities and bioactivities of MK-4166 and DTA-1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249f3473bfc76fc6a9343fe15e701207
https://doi.org/10.1158/0008-5472.22414407.v1
https://doi.org/10.1158/0008-5472.22414407.v1
Autor:
Svetlana Sadekova, Amy M. Beebe, Aarron Willingham, Terrill K. McClanahan, Danuta Herzyk, Wendy J. Bailey, Venkataraman Sriram, Elaine M. Pinheiro, Denise Manfra, Peter Georgiev, Ruban Mangadu, Tatyana Churakova, Jeff Grein, Antoaneta S. Necheva, Bhagyashree Bhagwat, Romina Riener, Grigori Ermakov, Saraswathi Naravula, Jerelyn Wong, Ying Yu, Douglas C. Wilson, Selvakumar Sukumar
This file contains supplementary methods that describe the antibodies used, the generation and characterization of MK-4166, various cell-based assays, and the evaluation of toxicity in cynomolgus monkeys.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69827d21a8c9e0175677d7a8489838f7
https://doi.org/10.1158/0008-5472.22414410.v1
https://doi.org/10.1158/0008-5472.22414410.v1
Autor:
Renu Jain, Daniel J. Cua, Amy M. Beebe, Edward P. Bowman, Jane Xia, Barbara Joyce-Shaikh, Smita Mauze, Ashley E. Mahne
Supplementary Materials and Methods include Treg lineage tracing data in B16 melanoma tumor model and binding, pharmacokinetics characterization and agonist signaling activity data for mDTA-1 Fc mutant antibody.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac176463991410d7d89b3b66898ce5f
https://doi.org/10.1158/0008-5472.22415922.v1
https://doi.org/10.1158/0008-5472.22415922.v1
Autor:
Svetlana Sadekova, Amy M. Beebe, Aarron Willingham, Terrill K. McClanahan, Danuta Herzyk, Wendy J. Bailey, Venkataraman Sriram, Elaine M. Pinheiro, Denise Manfra, Peter Georgiev, Ruban Mangadu, Tatyana Churakova, Jeff Grein, Antoaneta S. Necheva, Bhagyashree Bhagwat, Romina Riener, Grigori Ermakov, Saraswathi Naravula, Jerelyn Wong, Ying Yu, Douglas C. Wilson, Selvakumar Sukumar
GITR is a T-cell costimulatory receptor that enhances cellular and humoral immunity. The agonist anti-mouse GITR antibody DTA-1 has demonstrated efficacy in murine models of cancer primarily by attenuation of Treg-mediated immune suppression, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bfee5aa1afeba34ec05f3cba4f5fee8
https://doi.org/10.1158/0008-5472.c.6508965.v1
https://doi.org/10.1158/0008-5472.c.6508965.v1
Autor:
Svetlana Sadekova, Amy M. Beebe, Aarron Willingham, Terrill K. McClanahan, Danuta Herzyk, Wendy J. Bailey, Venkataraman Sriram, Elaine M. Pinheiro, Denise Manfra, Peter Georgiev, Ruban Mangadu, Tatyana Churakova, Jeff Grein, Antoaneta S. Necheva, Bhagyashree Bhagwat, Romina Riener, Grigori Ermakov, Saraswathi Naravula, Jerelyn Wong, Ying Yu, Douglas C. Wilson, Selvakumar Sukumar
Supplementary Figure S1 shows the gating scheme and markers used to phenotype various T cell subsets in human blood. Supplementary Figure S2 shows the expression of GITR on human and cynomolgus monkey NK cells and T cells. Supplementary Figure S3 sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b1719210763f1f05971391ff03d06a
https://doi.org/10.1158/0008-5472.22414413.v1
https://doi.org/10.1158/0008-5472.22414413.v1
Autor:
Alyssa J Fielitz, Jeremy M Beebe, Dongchan Ahn, Marius Chyasnavichyus, Tyler R Heyl, Myoungbae Lee, Shane Mangold, Carl Reinhardt, Kenneth R Shull, Anthony J Silvaroli, Muzhou Wang
Publikováno v:
Microscopy and Microanalysis. 28:222-223
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c7bb6b8a7027353f75927d6e2e702e1
https://doi.org/10.1017/s1431927622001738
https://doi.org/10.1017/s1431927622001738