Zobrazeno 1 - 10
of 41
pro vyhledávání: '"A M, Akimzhanov"'
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Calcium influx through plasma membrane ion channels is crucial for many events in cellular physiology. Cell surface stimuli lead to the production of inositol 1,4,5-trisphosphate (IP3), which binds to IP3 receptors (IP3R) in the endoplasmic reticulum
Externí odkaz:
https://doaj.org/article/bd8a35e06343447c9f07379db6addf1e
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
S-acylation, the reversible lipidation of free cysteine residues with long-chain fatty acids, is a highly dynamic post-translational protein modification that has recently emerged as an important regulator of the T cell function. The reversible natur
Externí odkaz:
https://doaj.org/article/13a3f8c5f9d34ab9a3939129748fb586
Autor:
Alexes C. Daquinag, Zhanguo Gao, Cale Fussell, Linnet Immaraj, Renata Pasqualini, Wadih Arap, Askar M. Akimzhanov, Maria Febbraio, Mikhail G. Kolonin
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
The mechanism controlling long-chain fatty acid (LCFA) mobilization from adipose tissue is not well understood. Here, we investigated how the LCFA transporter CD36 regulates this process. By using tissue-specific KO mouse models, we showed that CD36
Externí odkaz:
https://doaj.org/article/0c5f6b75c99c4de4987b466950096124
Autor:
Alexander Andersohn, M. Iveth Garcia, Ying Fan, Max C. Thompson, Askar M. Akimzhanov, Abdikarim Abdullahi, Marc G. Jeschke, Darren Boehning
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Chronic ER stress occurs when protein misfolding in the Endoplasmic reticulum (ER) lumen remains unresolved despite activation of the unfolded protein response. We have shown that traumatic injury such as a severe burn leads to chronic ER stress in v
Externí odkaz:
https://doaj.org/article/5cbebce8c3ec407f89f23bcb19ebc8a2
Publikováno v:
Biophysical Journal. 122:373a-374a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7a53740c02a1d01fd8d8222fb8b3a6b
https://doi.org/10.1016/j.bpj.2022.11.2057
https://doi.org/10.1016/j.bpj.2022.11.2057
Publikováno v:
Mol Biol Rep
S-acylation – reversible post-translational lipidation of cysteine residues – is emerging as an important regulatory mechanism in T cell signaling. Dynamic S-acylation is critical for protein recruitment into the T cell receptor complex and initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a7dcffc24b2b24fcb6ab357713cbd5
https://doi.org/10.1007/s11033-020-05691-1
https://doi.org/10.1007/s11033-020-05691-1
Autor:
Goutham Kodkandla, Savannah J West, Qiaochu Wang, Ritika Tewari, Michael X. Zhu, Askar M. Akimzhanov, Darren Boehning
Many cell surface stimuli cause calcium release from endoplasmic reticulum (ER) stores to regulate cellular physiology. Upon ER calcium store depletion, the ER-resident protein STIM1 physically interacts with plasma membrane protein Orai1 to induce c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c6de8fe0abc0ae479256b3d5bad27b3
https://doi.org/10.1101/2022.02.15.480522
https://doi.org/10.1101/2022.02.15.480522
Autor:
Goutham, Kodakandla, Savannah J, West, Qiaochu, Wang, Ritika, Tewari, Michael X, Zhu, Askar M, Akimzhanov, Darren, Boehning
Publikováno v:
The Journal of biological chemistry. 298(9)
Many cell surface stimuli cause calcium release from endoplasmic reticulum (ER) stores to regulate cellular physiology. Upon ER calcium store depletion, the ER-resident protein stromal interaction molecule 1 (STIM1) physically interacts with plasma m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd0a18b25924fa38bbc808448381bf2a
https://pubmed.ncbi.nlm.nih.gov/35934052
https://pubmed.ncbi.nlm.nih.gov/35934052
Publikováno v:
Biophysical Journal
S-palmitoylation is a reversible posttranslational modification that plays an important role in regulating protein localization, trafficking, and stability. Recent studies have shown that some proteins undergo extremely rapid palmitoylation/depalmito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e7b0cd5b2df6ce5cb6588afcc55ce6
http://europepmc.org/articles/PMC7036738
http://europepmc.org/articles/PMC7036738
Autor:
Ritika Tewari, Ying Fan, Junsuk Ko, Shayahati Bieerkehazhi, Tingting Mills, Darren Boehning, Askar M. Akimzhanov, Savannah J. West
Publikováno v:
J Cell Sci
Despite the recognized significance of reversible protein lipidation (S-acylation) for T cell receptor signal transduction, the enzymatic control of this post-translational modification in T cells remains poorly understood. Here, we demonstrate that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1701a89abadc7602f697bdb38b2ffef
https://doi.org/10.1242/jcs.258186
https://doi.org/10.1242/jcs.258186