Výsledky vyhledávání - "A Lopez Mendez"

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Modulating the magnetic properties of Fe3C/C encapsulated core/shell nanoparticles for potential prospects in biomedicine

Autor: Castellano-Soria, A., Lopez-Mendez, R., Espinosa, A., Granados-Miralles, C., Varela, M., Marin, P., Navarro, E., Lopez-Sanchez, J.

In the pursuit of alternative and less invasive medical treatments, magnetic nanoparticles (NPs) have gained significant relevance. Iron carbides NPs stand out for their higher saturation magnetizations compared to iron oxides, while maintaining a su

Externí odkaz: http://arxiv.org/abs/2410.00723

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Akademický článek

Streamlined analysis of drug targets by proteome integral solubility alteration indicates organ-specific engagement

Autor: Tanveer Singh Batth, Marie Locard-Paulet, Nadezhda T. Doncheva, Blanca Lopez Mendez, Lars Juhl Jensen, Jesper Velgaard Olsen

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Proteins are the primary targets of almost all small molecule drugs. However, even the most selectively designed drugs can potentially target several unknown proteins. Identification of potential drug targets can facilitate design of new dru

Externí odkaz: https://doaj.org/article/596874fe32fc4c529293f9473a9ae2e0

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Akademický článek

Neutralisation Resistance of SARS-CoV-2 Spike-Variants is Primarily Mediated by Synergistic Receptor Binding Domain Substitutions

Autor: Long V. Pham, Alexander P. Underwood, Alekxander Binderup, Ulrik Fahnøe, Carlota Fernandez-Antunez, Blanca Lopez-Mendez, Line Abildgaard Ryberg, Andrea Galli, Christina Sølund, Nina Weis, Santseharay Ramirez, Jens Bukh

Publikováno v: Emerging Microbes and Infections (2024)

The evolution of SARS-CoV-2 has led to the emergence of numerous variants of concern (VOCs), marked by changes in the viral spike glycoprotein, the primary target for neutralising antibody (nAb) responses. Emerging VOCs, particularly omicron sub-line

Externí odkaz: https://doaj.org/article/a92a700b014849119526b7299e799525

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Akademický článek

VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates

Autor: Ann Schirin Mirsanaye, Saskia Hoffmann, Melanie Weisser, Andreas Mund, Blanca Lopez Mendez, Dimitris Typas, Johannes van den Boom, Bente Benedict, Ivo A. Hendriks, Michael Lund Nielsen, Hemmo Meyer, Julien P. Duxin, Guillermo Montoya, Niels Mailand

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract The hexameric AAA+ ATPase p97/VCP functions as an essential mediator of ubiquitin-dependent cellular processes, extracting ubiquitylated proteins from macromolecular complexes or membranes by catalyzing their unfolding. p97 is directed to ub

Externí odkaz: https://doaj.org/article/94acc0facb2c40838b11f84474d25e74

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