Zobrazeno 1 - 10
of 1 192
pro vyhledávání: '"A Lessells"'
Autor:
Farina Karim, Catherine Riou, Mallory Bernstein, Zesuliwe Jule, Gila Lustig, Strauss van Graan, Roanne S. Keeton, Janine-Lee Upton, Yashica Ganga, Khadija Khan, Kajal Reedoy, Matilda Mazibuko, Katya Govender, Kershnee Thambu, Nokuthula Ngcobo, Elizabeth Venter, Zanele Makhado, Willem Hanekom, Anne von Gottberg, Monjurul Hoque, Quarraisha Abdool Karim, Salim S. Abdool Karim, Nithendra Manickchund, Nombulelo Magula, Bernadett I. Gosnell, Richard J. Lessells, Penny L. Moore, Wendy A. Burgers, Tulio de Oliveira, Mahomed-Yunus S. Moosa, Alex Sigal
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract SARS-CoV-2 clearance requires adaptive immunity but the contribution of neutralizing antibodies and T cells in different immune states is unclear. Here we ask which adaptive immune responses associate with clearance of long-term SARS-CoV-2 i
Externí odkaz:
https://doaj.org/article/cf97d17abeb74e59ba27f92ef737342a
Autor:
Stefanie Hossmann, Antoine Jaquet, Matthias Egger, Richard Lessells, Jeremy Ross, Mamatha Sauermann, Tom Loosli, Selma Riedo, Niko Beerenwinkel, Albert Minga, Jennifer Giandhari, Roger D Kouyos
Publikováno v:
BMJ Open, Vol 14, Iss 8 (2024)
Introduction HIV drug resistance poses a challenge to the United Nation’s goal of ending the HIV/AIDS epidemic. The integrase strand transfer inhibitor (InSTI) dolutegravir, which has a higher resistance barrier, was endorsed by the WHO in 2019 for
Externí odkaz:
https://doaj.org/article/cdb698d44ddf40a39cf421b625d97203
Autor:
Wonderful T. Choga, Gobuiwang Khilly Kurusa (Gasenna), James Emmanuel San, Tidimalo Ookame, Irene Gobe, Mohammed Chand, Badisa Phafane, Kedumetse Seru, Patience Matshosi, Boitumelo Zuze, Nokuthula Ndlovu, Teko Matsuru, Dorcas Maruapula, Ontlametse T. Bareng, Kutlo Macheke, Lesego Kuate-Lere, Labapotswe Tlale, Onalethata Lesetedi, Modiri Tau, Mpaphi B. Mbulawa, Pamela Smith-Lawrence, Mogomotsi Matshaba, Roger Shapiro, Joseph Makhema, Darren P. Martin, Tulio de Oliveira, Richard J. Lessells, Shahin Lockman, Simani Gaseitsiwe, Sikhulile Moyo
Publikováno v:
International Journal of Infectious Diseases, Vol 138, Iss , Pp 91-96 (2024)
We investigated intra-host genetic evolution using two SARS-CoV-2 isolates from a fully vaccinated (primary schedule x2 doses of AstraZeneca plus a booster of Pfizer), >70-year-old woman with a history of lymphoma and hypertension who presented a SAR
Externí odkaz:
https://doaj.org/article/a4563b67ede2463ca061c016f76e974e
Autor:
Khadija Khan, Gila Lustig, Cornelius Römer, Kajal Reedoy, Zesuliwe Jule, Farina Karim, Yashica Ganga, Mallory Bernstein, Zainab Baig, Laurelle Jackson, Boitshoko Mahlangu, Anele Mnguni, Ayanda Nzimande, Nadine Stock, Dikeledi Kekana, Buhle Ntozini, Cindy van Deventer, Terry Marshall, Nithendra Manickchund, Bernadett I. Gosnell, Richard J. Lessells, Quarraisha Abdool Karim, Salim S. Abdool Karim, Mahomed-Yunus S. Moosa, Tulio de Oliveira, Anne von Gottberg, Nicole Wolter, Richard A. Neher, Alex Sigal
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Omicron BA.2.86 subvariant differs from Omicron BA.2 as well as recently circulating variants by over 30 mutations in the spike protein alone. Here we report on the isolation of the live BA.2.86 subvariant from a diagnostic swab collected in
Externí odkaz:
https://doaj.org/article/385191ebb6d244fb85921e20444d30a5
Autor:
Lilishia Gounder, Aabida Khan, Justen Manasa, Richard Lessells, Andrew Tomita, Melendhran Pillay, Sontaga C. Manyana, Subitha Govender, Kerri-Lee Francois, Pravi Moodley, Nokukhanya Msomi, Kerusha Govender, Raveen Parboosing, Sikhulile Moyo, Kogieleum Naidoo, Benjamin Chimukangara
Publikováno v:
Viruses, Vol 16, Iss 10, p 1634 (2024)
HIV-1 drug resistance (HIVDR) impedes treatment and control of HIV-1, especially in high-prevalence settings such as KwaZulu-Natal (KZN) province, South Africa. This study merged routine HIV-1 genotypic resistance test (GRT) data with Geographic Info
Externí odkaz:
https://doaj.org/article/9b3d7477fcde4994875db26cd6c2d8f2
Autor:
Reshma Kassanjee, Mary-Ann Davies, Alexa Heekes, Hassan Mahomed, Anthony J. Hawkridge, Erna Morden, Theuns Jacobs, Cheryl Cohen, Harry Moultrie, Richard J. Lessells, Nicolette Van Der Walt, Juanita O. Arendse, Nicole Wolter, Sibongile Walaza, Waasila Jassat, Anne von Gottberg, Patrick L. Hannan, Daniel R. Feikin, Keith Cloete, Andrew Boulle
Publikováno v:
Vaccines, Vol 12, Iss 6, p 628 (2024)
There are few data on the real-world effectiveness of COVID-19 vaccines and boosting in Africa, which experienced widespread SARS-CoV-2 infection before vaccine availability. We assessed the association between vaccination and severe COVID-19 in the
Externí odkaz:
https://doaj.org/article/73b42dbbb6244652bb27cbc9b2f270fe
Autor:
Asare, Kwabena *, Sookrajh, Yukteshwar, van der Molen, Johan, Khubone, Thokozani, Lewis, Lara, Lessells, Richard J, Naidoo, Kogieleum, Sosibo, Phelelani, van Heerden, Rosemary, Garrett, Nigel, Dorward, Jienchi
Publikováno v:
In The Lancet Global Health February 2024 12(2):e282-e291
Autor:
Joyce Protas Mlay, Thirusha Naidu, Suvira Ramlall, Sbusisiwe Sandra Mhlungu, Makhosazane Zondi, Richard Lessells, Jennifer I Manuel, Andrew Tomita
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0309238 (2024)
IntroductionRelapse among individuals with serious mental illnesses in resource-limited contexts, including South Africa, is a significant concern. To date, the risks for relapse among this population is well documented, but little is known about pre
Externí odkaz:
https://doaj.org/article/47fb9f1b139842eeaaa50ad8e862414b
Autor:
Lilishia Gounder, Andrew Tomita, Richard Lessells, Sandrini Moodley, Kerri-Lee Francois, Aabida Khan, Melendhran Pillay, Sontaga C Manyana, Subitha Govender, Kerusha Govender, Pravi Moodley, Raveen Parboosing, Nokukhanya Msomi, Frank Tanser, Kogieleum Naidoo, Benjamin Chimukangara
Publikováno v:
PLOS Global Public Health, Vol 4, Iss 5, p e0003224 (2024)
South Africa rolled out dolutegravir (DTG) as first-line antiretroviral therapy (ART) in December 2019 to overcome high rates of pretreatment non-nucleoside reverse transcriptase inhibitor drug resistance. In the context of transition to DTG-based AR
Externí odkaz:
https://doaj.org/article/d67f1eec97dc4715a89305e9d69f3aa4
Autor:
Daniel DeSanto, Kavindhran Velen, Richard Lessells, Sewele Makgopa, Dumile Gumede, Katherine Fielding, Alison D Grant, Salome Charalambous, Candice M Chetty-Makkan
Publikováno v:
BMC Public Health, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Tuberculosis (TB) stigma is a barrier to active case finding and delivery of care in fighting the TB epidemic. As part of a project exploring different models for delivery of TB contact tracing, we conducted a qualitative analysis
Externí odkaz:
https://doaj.org/article/3764774eb30441b288014e7cca2b380f