Zobrazeno 1 - 10
of 996
pro vyhledávání: '"A L Shaffer"'
Autor:
Johid Reza Malik, Anthony T. Podany, Parvez Khan, Christopher L. Shaffer, Jawed A. Siddiqui, Janina Baranowska‐Kortylewicz, Jennifer Le, Courtney V. Fletcher, Sadia Afruz Ether, Sean N. Avedissian
Publikováno v:
Cancer Medicine, Vol 12, Iss 23, Pp 21075-21096 (2023)
Abstract Background Pediatric brain tumors (PBT) stand as the leading cause of cancer‐related deaths in children. Chemoradiation protocols have improved survival rates, even for non‐resectable tumors. Nonetheless, radiation therapy carries the ri
Externí odkaz:
https://doaj.org/article/f2207ce95fd54c1b9b1d541780c66a2c
Autor:
Elsie Diaz, Suraj Adhikary, Armand W. J. W. Tepper, Daniel Riley, Rodrigo Ortiz-Meoz, Daniel Krosky, Christophe Buyck, Carolina Martinez Lamenca, Josep Llaveria, Lichao Fang, Jay H. Kalin, Vincent N. A. Klaren, Shorouk Fahmy, Paul L. Shaffer, Robert Kirkpatrick, Rodrigo J. Carbajo, Maren Thomsen, Antonietta Impagliazzo
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Rational engineering of human spermine oxidase yields crystallizable structures and the design of an allosteric inhibitor.
Externí odkaz:
https://doaj.org/article/391009d10cb04621862722699df90a61
Autor:
Bonnie Huang, James D. Phelan, Silvia Preite, Julio Gomez-Rodriguez, Kristoffer H. Johansen, Hirofumi Shibata, Arthur L. Shaffer, Qin Xu, Brendan Jeffrey, Martha Kirby, Stacie Anderson, Yandan Yang, Selamawit Gossa, Dorian B. McGavern, Louis M. Staudt, Pamela L. Schwartzberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
T follicular helper (Tfh) and T help type 1 (Th1) cells both arise from naïve CD4 T cells, but detailed knowledge of their differentiation remains incomplete. Here the authors pursue an in vivo CRISPR screen to identify genes, focusing on druggable
Externí odkaz:
https://doaj.org/article/f2c40bd54ddf4ca49421a503fe6ad4d6
Autor:
Tsehai A.J. Grell, Mark Mason, Aaron A. Thompson, Jose Carlos Gómez-Tamayo, Daniel Riley, Michelle V. Wagner, Ruth Steele, Rodrigo F. Ortiz-Meoz, Jay Wadia, Paul L. Shaffer, Gary Tresadern, Sujata Sharma, Xiaodi Yu
Publikováno v:
Heliyon, Vol 8, Iss 12, Pp e12392- (2022)
Malic enzymes (ME1, ME2, and ME3) are involved in cellular energy regulation, redox homeostasis, and biosynthetic processes, through the production of pyruvate and reducing agent NAD(P)H. Recent studies have implicated the third and least well-charac
Externí odkaz:
https://doaj.org/article/0f71dae03abd4550a60deb71f7723386
Autor:
Elliott R. Haut, Oluwafemi P. Owodunni, Jiangxia Wang, Dauryne L. Shaffer, Deborah B. Hobson, Gayane Yenokyan, Peggy S. Kraus, Norma E. Farrow, Joseph K. Canner, Katherine L. Florecki, Kristen L.W. Webster, Christine G. Holzmueller, Jonathan K. Aboagye, Victor O. Popoola, Mujan Varasteh Kia, Peter J. Pronovost, Michael B. Streiff, Brandyn D. Lau
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 18 (2022)
Background Many hospitalized patients are not administered prescribed doses of pharmacologic venous thromboembolism prophylaxis. Methods and Results In this cluster‐randomized controlled trial, all adult non–intensive care units (10 medical, 6 su
Externí odkaz:
https://doaj.org/article/cf123f883da349169b6c0d5b54826a7b
Autor:
Kelly C L Shaffer, Sean Hui, Anna Bratcher, Liam B King, Rachel Mutombe, Nathalie Kavira, Jean Paul Kompany, Merly Tambu, Kamy Musene, Patrick Mukadi, Placide Mbala, Adva Gadoth, Brandyn R West, Benoit Kebela Ilunga, Didine Kaba, Jean Jacques Muyembe-Tanfum, Nicole A Hoff, Anne W Rimoin, Erica Ollmann Saphire
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 3, p e0010167 (2022)
Although multiple antigenically distinct ebolavirus species can cause human disease, previous serosurveys focused on only Zaire ebolavirus (EBOV). Thus, the extent of reactivity or exposure to other ebolaviruses, and which sociodemographic factors ar
Externí odkaz:
https://doaj.org/article/e6920166dc554d05ac47096d21e79aa1
Akademický článek
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Autor:
Mindy H Lee, Catherine C Applegate, Annabelle L Shaffer, Abrar Emamaddin, John W Erdman, Manabu T Nakamura
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0267876 (2022)
Obesity is a significant contributor to the development of chronic diseases, some of which can be prevented or reversed by weight loss. However, dietary weight loss programs have shortcomings in the success rate, magnitude, or sustainability of weigh
Externí odkaz:
https://doaj.org/article/33250e06efc644efbb75ff72dba64eca
Autor:
Mohammed Kaplan, Georges Chreifi, Lauren Ann Metskas, Janine Liedtke, Cecily R Wood, Catherine M Oikonomou, William J Nicolas, Poorna Subramanian, Lori A Zacharoff, Yuhang Wang, Yi-Wei Chang, Morgan Beeby, Megan J Dobro, Yongtao Zhu, Mark J McBride, Ariane Briegel, Carrie L Shaffer, Grant J Jensen
Publikováno v:
eLife, Vol 10 (2021)
The ability to produce outer membrane projections in the form of tubular membrane extensions (MEs) and membrane vesicles (MVs) is a widespread phenomenon among diderm bacteria. Despite this, our knowledge of the ultrastructure of these extensions and
Externí odkaz:
https://doaj.org/article/9dc4069a6dfe4d3c9e60a677f0b20699
Autor:
Andrea J. Loizeau, Erika M. C. D’Agata, Michele L. Shaffer, Laura C. Hanson, Ruth A. Anderson, Timothy Tsai, Daniel A. Habtemariam, Elaine H. Bergman, Ruth P. Carroll, Simon M. Cohen, Erin M. E. Scott, Erin Stevens, Jeremy D. Whyman, Elizabeth H. Bennert, Susan L. Mitchell
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background Infections are common in nursing home (NH) residents with advanced dementia but are often managed inappropriately. Antimicrobials are extensively prescribed, but frequently with insufficient evidence to support a bacterial infecti
Externí odkaz:
https://doaj.org/article/21ffed57aec24b6cb1694d1450d5202e