Zobrazeno 1 - 10
of 2 403
pro vyhledávání: '"A L Nielsen"'
Autor:
Zita Fábián, Ellen S. Kakulidis, Ivo A. Hendriks, Ulrike Kühbacher, Nicolai B. Larsen, Marta Oliva-Santiago, Junhui Wang, Xueyuan Leng, A. Barbara Dirac-Svejstrup, Jesper Q. Svejstrup, Michael L. Nielsen, Keith Caldecott, Julien P. Duxin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central role in DPC resolution, but whether other PTMs are also inv
Externí odkaz:
https://doaj.org/article/427734112e584ecc9b9b66e9b3111faa
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract To gain insights into the composition and heterogeneity of Earth’s interior, the partial pressure of oxygen (oxygen fugacity, or fO2) in igneous rocks is characterized. A surprising observation is that relative to reference buffers, fO2s o
Externí odkaz:
https://doaj.org/article/b8210e032d4e459fba9a19e827a0d940
Autor:
Trine Sørensen, Celine Petersen, Asmus T. Muurmann, Johan V. Christiansen, Mathias L. Brundtø, Christina K. Overgaard, Anders T. Boysen, Rasmus D. Wollenberg, Thomas O. Larsen, Jens L. Sørensen, Kåre L. Nielsen, Teis E. Sondergaard
Publikováno v:
IMA Fungus, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The Apiospora genus comprises filamentous fungi with promising potential, though its full capabilities remain undiscovered. In this study, we present the first genome assembly of an Apiospora arundinis isolate, demonstrating a highly complet
Externí odkaz:
https://doaj.org/article/de65fb63a310423aba25ec2ed13824a8
Autor:
Camilla S. Colding-Christensen, Ellen S. Kakulidis, Javier Arroyo-Gomez, Ivo A. Hendriks, Connor Arkinson, Zita Fábián, Agnieszka Gambus, Niels Mailand, Julien P. Duxin, Michael L. Nielsen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Ubiquitin widely modifies proteins, thereby regulating most cellular functions. The complexity of ubiquitin signalling necessitates unbiased methods enabling global detection of dynamic protein ubiquitylation. Here, we describe UBIMAX (UBiqu
Externí odkaz:
https://doaj.org/article/c45c5dfb98ea4d949da491f277c33fef
Autor:
Sagar B. Dugani, MD, PhD, MPH, Shangwe A. Kiliaki, CNP, DNP, Megan L. Nielsen, MSN, CNP, Karen M. Fischer, MPH, Megan Lunde, Gina M. Kesselring, MPAS, PA-C, Donna K. Lawson, CCRP, Trevor J. Coons, MHA, Holly A. Schenzel, CNP, DNP, Riddhi S. Parikh, MBBS, Sandeep R. Pagali, MD, MPH, Anne Liwonjo, MD, Ivana T. Croghan, MS, PhD, Darrell R. Schroeder, MS, M. Caroline Burton, MD
Publikováno v:
Mayo Clinic Proceedings: Digital Health, Vol 1, Iss 3, Pp 368-378 (2023)
Objective: To determine whether a postdischarge video visit with patients, conducted by hospital medicine advanced practice providers, improves adherence to hospital discharge recommendations. Patients and Methods: We conducted a single-institution 2
Externí odkaz:
https://doaj.org/article/067e665522c24e168b9c544555e73dbe
Autor:
Katrine V. Møller, Jonas Bruhn Wesseltoft, Richelle Malazarte, Sabrina J. Kousgaard, Hans L. Nielsen, Erika Yashiro, Anders Olsen
Publikováno v:
Applied Microbiology, Vol 3, Iss 4, Pp 1130-1143 (2023)
The role of the microbiota in health and disease is a research area receiving much attention in academia and industry. A person’s microbiota refers to a community of microorganisms found mainly in the gut. It is estimated that around 39 trillion ba
Externí odkaz:
https://doaj.org/article/f711fc80df4b4a349c15d54fcdfb902a
Autor:
Chao-Yu Hsu, Jyun-Yi Li, En-Ying Yang, Tsai-Ling Liao, Hsiao-Wei Wen, Pei-Chien Tsai, Tz-Chuen Ju, Lon-Fye Lye, Brent L. Nielsen, Hung-Jen Liu
Publikováno v:
Viruses, Vol 16, Iss 7, p 1153 (2024)
To explore whether the p17 protein of oncolytic avian reovirus (ARV) mediates cell migration and invadopodia formation, we applied several molecular biological approaches for studying the involved cellular factors and signal pathways. We found that A
Externí odkaz:
https://doaj.org/article/a9d709f2c4354e8fbb700714f8004fe2
Autor:
Meeli Mullari, Nicolas Fossat, Niels H. Skotte, Andrea Asenjo-Martinez, David T. Humphreys, Jens Bukh, Agnete Kirkeby, Troels K. H. Scheel, Michael L. Nielsen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract RNA-binding proteins (RBPs) are key players regulating RNA processing and are associated with disorders ranging from cancer to neurodegeneration. Here, we present a proteomics workflow for large-scale identification of RBPs and their RNA-bin
Externí odkaz:
https://doaj.org/article/af7bee72a0c145a5ad5d646db7ed76f4
Autor:
Frederick Richards, Marta J. Llorca-Cardenosa, Jamie Langton, Sara C. Buch-Larsen, Noor F. Shamkhi, Abhishek Bharadwaj Sharma, Michael L. Nielsen, Nicholas D. Lakin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Although Poly(ADP-ribose)-polymerases (PARPs) are key regulators of genome stability, how site-specific ADP-ribosylation regulates DNA repair is unclear. Here, we describe a novel role for PARP1 and PARP2 in regulating Rad52-dependent replic
Externí odkaz:
https://doaj.org/article/83b10039e6eb483590c97f8398987d26
Autor:
Pietro Fontana, Sara C. Buch-Larsen, Osamu Suyari, Rebecca Smith, Marcin J. Suskiewicz, Kira Schützenhofer, Antonio Ariza, Johannes Gregor Matthias Rack, Michael L. Nielsen, Ivan Ahel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract In the mammalian DNA damage response, ADP-ribosylation signalling is of crucial importance to mark sites of DNA damage as well as recruit and regulate repairs factors. Specifically, the PARP1:HPF1 complex recognises damaged DNA and catalyses
Externí odkaz:
https://doaj.org/article/cff60a6288a743aba7c65be11a327f44