Výsledky vyhledávání - "A L, Zignego"

Akademický článek

Non-Invasive Quantification of Cartilage Using a Novel In Vivo Bioluminescent Reporter Mouse.

Autor: Sarah E Mailhiot, Donald L Zignego, Justin R Prigge, Ella R Wardwell, Edward E Schmidt, Ronald K June

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0130564 (2015)

Mouse models are common tools for examining post-traumatic osteoarthritis (OA), which involves cartilage deterioration following injury or stress. One challenge to current mouse models is longitudinal monitoring of the cartilage deterioration in vivo

Externí odkaz: https://doaj.org/article/fae141c33624471abc2cab2197490749

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SARS-CoV-2 was already circulating in Italy, in early December 2019

Autor: Gragnani, L, Monti, M, A Santini, S, Marri, S, Madia, F, Lorini, S, Petraccia, L, Stasi, C, Basile, U, Luti, V, Pagliai, F, Saccardi, R, L Zignego, A

Publikováno v: European review for medical and pharmacological sciences. 25(8)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) identified in China, in December 2019 determines COronaVIrus Disease 19 (COVID-19). Whether or not the virus was present in Italy earlier the first autochthonous COVID-19 case was diagnosed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8dc71a1c4944f2d5eb5a5a7b9060c63f
https://pubmed.ncbi.nlm.nih.gov/33928622

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POS1214 COVID-19 VACCINATION RATE AND SAFETY PROFILE IN PATIENTS AFFECTED BY MIXED CRYOGLOBULINEMIC VASCULITIS

Autor: C. Vacchi, S. Testoni, M. Visentini, R. Zani, G. Lauletta, L. Gragnani, D. A. Filippini, C. Mazzaro, P. Fraticelli, L. Quartuccio, R. Padoan, L. Castelnovo, A. L. Zignego, C. Ferri, A. Hoxha, C. Salvarani, G. Monti, M. Galli, M. Sebastiani

Publikováno v: Annals of the Rheumatic Diseases. 81:936-936

BackgroundMixed cryoglobulinaemic vasculitis (MCV) is an immune-complex-mediated systemic vasculitis characterized by heterogeneous clinical manifestations mainly involving skin, kidney and peripheral nervous system.Despite reassuring safety data fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04f9550a07ad61029fd2e32c5c1a1207
https://doi.org/10.1136/annrheumdis-2022-eular.1426

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POS1267 LONG-TERM SURVEY STUDY OF THE IMPACT OF COVID-19 ON SYSTEMIC AUTOIMMUNE DISEASES. LOW DEATH RATE DESPITE THE INCREASED PREVALENCE OF SYMPTOMATIC INFECTION. ROLE OF PRE-EXISTING INTERSTITIAL LUNG DISEASE AND ONGOING TREATMENTS

Autor: C. Ferri, V. Raimondo, L. Gragnani, D. Giuggioli, L. Dagna, A. Tavoni, F. Ursini, M. L’andolina, F. Caso, P. Ruscitti, M. Caminiti, R. Foti, V. Riccieri, S. Guiducci, R. Pellegrini, E. Zanatta, G. Varcasia, D. Olivo, P. Gigliotti, G. Cuomo, G. Murdaca, R. Cecchetti, R. De Angelis, N. Romeo, F. Ingegnoli, F. Cozzi, V. Codullo, I. Cavazzana, M. Colaci, G. Abignano, M. De Santis, E. Lubrano, E. Fusaro, A. Spinella, F. Lumetti, G. De Luca, S. Bellando Randone, E. Visalli, Y. Dal Bosco, G. Amato, D. Giannini, S. Bilia, F. Masini, G. Pellegrino, E. Pigatto, E. Generali, G. Pagano Mariano, G. Pettiti, G. Zanframundo, R. Brittelli, V. Aiello, R. Caminiti, D. Scorpiniti, T. Ferrari, C. Campochiaro, V. Brusi, M. Fredi, L. Moschetti, F. Cacciapaglia, S. M. Ferrari, I. DI Cola, M. Vadacca, S. Lorusso, M. Monti, S. Lorini, S. R. Paparo, F. Ragusa, G. Elia, V. Mazzi, M. L. Aprile, M. Tasso, M. Miccoli, S. L. Bosello, S. D’angelo, A. Doria, F. Franceschini, R. Meliconi, M. Matucci-Cerinic, F. Iannone, R. Giacomelli, C. Salvarani, A. L. Zignego, P. Fallahi, A. Antonelli

Publikováno v: Annals of the Rheumatic Diseases. 81:970.2-971

BackgroundPatients with autoimmune systemic diseases (ASDs) can be counted among frail populations as regards the predisposition to COVID-19 due to the frequent visceral organ involvement and comorbidities, as well as the ongoing immunomodulating tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90a1cedb857e19b11f7ac5dec491e2c7
https://doi.org/10.1136/annrheumdis-2022-eular.4522

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Primary human chondrocytes respond to compression with plasma membrane receptors and by microtubule activation: a phosphoproteomic study

Autor: William J. Schell, Ronald K. June, Brian Bothner, Donald L. Zignego, Jonathan K. Hilmer

Chondrocytes are responsible for maintaining the cartilage that helps joints like the knee and hip bear load and move smoothly. These cells typically respond to physiological compression with pathways consistent with matrix synthesis, and chondrocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef6bf5bff75a8181fbd77408596f56f

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A novel biomarker score for the screening and management of patients with plasma cell proliferative disorders

Autor: U, Basile, F, Gulli, M A, Isgrò, C, Napodano, K, Pocino, S A, Santini, L, Gragnani, L, Conti, E, Rossi, I, Cordone, A L, Zignego, G L, Rapaccini, G, Cigliana, F, Berruti, L, Todi, M, Marino, E, Di Stasio

Publikováno v: European review for medical and pharmacological sciences. 23(10)

Monoclonal plasma cell proliferative disorders comprise a wide spectrum of diseases associated to clonal B-cell expansion. Serum protein electrophoretic profile (SPEP) and circulating free light chains (FLCs) levels are the mainstay of diseases manag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d768e7d53f957e2998a8fa66311eb596
https://pubmed.ncbi.nlm.nih.gov/31173301

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Inhibition of early response genes prevents changes in global joint metabolomic profiles in mouse post-traumatic osteoarthritis

Autor: Jasper H.N. Yik, Donald L. Zignego, Dominik R. Haudenschild, Jonathan K. Hilmer, Alyssa K. Carlson, Ronald K. June

Publikováno v: Osteoarthritis and cartilage, vol 27, iss 3

Osteoarthritis (OA) is the most common degenerative joint disease, and joint injury increases the risk of OA by 10-fold. Although the injury event itself damages joint tissues, a substantial amount of secondary damage is mediated by the cellular resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6afa40d2cf24e7c18b9a6e940689aa8
https://escholarship.org/uc/item/4x5375zd

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Mechanotransduction in primary human osteoarthritic chondrocytes is mediated by metabolism of energy, lipids, and amino acids

Autor: Jonathan K. Hilmer, Ronald K. June, Donald L. Zignego

Publikováno v: Journal of Biomechanics. 48:4253-4261

Chondrocytes are the sole cell type found in articular cartilage and are repeatedly subjected to mechanical loading in vivo. We hypothesized that physiological dynamic compression results in changes in energy metabolism to produce proteins for mainte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbeffaea481fadfe5f1696a98d8f060
https://doi.org/10.1016/j.jbiomech.2015.10.038

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Primary human chondrocytes respond to compression with phosphoproteomic signatures that include microtubule activation

Autor: Donald L. Zignego, Brian Bothner, Jonathan K. Hilmer, William J. Schell, Ronald K. June

Publikováno v: J Biomech

Chondrocytes are responsible for maintaining the cartilage that helps joints bear load and move smoothly. These cells typically respond to physiological compression with pathways consistent with matrix synthesis, and chondrocyte mechanotransduction i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749ad6181b828035c414074678ecab97
https://doi.org/10.1016/j.jbiomech.2019.109367

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Tearing of Thin Polymer Sheets with Wrinkling

Autor: Kyeongsik Woo, Donald L. Zignego, Christopher H. Jenkins

Publikováno v: Journal of Spacecraft and Rockets. 52:1680-1690

In this paper, the tearing behavior of thin polymer sheets was studied experimentally and numerically. First, the specific essential work of fracture for thin biaxially oriented polyethylene terephthalate (Mylar) was measured experimentally. Double-e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7cb732ee3f3dd56438e5eb1038f7572
https://doi.org/10.2514/1.a33283

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