Výsledky vyhledávání - "A L, Upthagrove"

Mass spectral fragmentation pathways of propranolol related β-fluorinated amines studied by electrospray and electron impact ionization

Autor: Wendel L. Nelson, Murray Hackett, Alana L. Upthagrove

Publikováno v: Rapid Communications in Mass Spectrometry. 13:1671-1679

Propranolol, its 1"-mono-, di-, and trifluorinated analogs, and other related compounds were analyzed under electrospray ionization ion trap collision-induced dissociation (ESI-CID) and electron impact (EI) conditions. Interesting trends were observe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46161a4a57fc4417f3212456c9c26ed2
https://doi.org/10.1002/(sici)1097-0231(19990830)13:16<1671::aid-rcm696>3.0.co

Zobrazit plný text záznamu

Fragmentation pathways of selectively labeled propranolol using electrospray ionization on an ion trap mass spectrometer and comparison with ions formed by electron impact

Autor: Murray Hackett, Wendel L. Nelson, Alana L. Upthagrove

Publikováno v: Rapid Communications in Mass Spectrometry. 13:534-541

Propranolol, deuterium- and 18O-labeled propranolol and related compounds were analyzed using an ion trap mass spectrometer equipped with a modified Finnigan API electrospray interface. Sequential product ion (MSn) experiments were used to elucidate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5215091d1176804090e534c2496a0466
https://doi.org/10.1002/(sici)1097-0231(19990330)13:6<534::aid-rcm520>3.0.co

Zobrazit plný text záznamu

(E)- and (Z)-7-Arylidenenaltrexones: Synthesis and Opioid Receptor Radioligand Displacement Assays

Autor: Robert B. Palmer, Wendel L. Nelson, and Alana L. Upthagrove

Publikováno v: Journal of Medicinal Chemistry. 40:749-753

The E-isomer of 7-benzylidenenaltrexone (BNTX, la) was reported by Portoghese as a highly selective delta-opioid antagonist. The corresponding Z-isomer 1b was not readily available through direct aldol condensation of naltrexone (6) with benzaldehyde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6b9692750fa2a6454d1814a087453c
https://doi.org/10.1021/jm960573f

Zobrazit plný text záznamu

Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol analogs: metabolism by CYP1A2

Autor: A L, Upthagrove, W L, Nelson

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(11)

A series of 1"-mono-, di-, and trifluorinated analogs of propranolol and related steric congeners was prepared, and their metabolism was examined with recombinant-expressed CYP1A2. The structural changes in this series of compounds, principally added

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77b5bc3daf5164d07b3b2fce042aba67
https://pubmed.ncbi.nlm.nih.gov/11602513

Zobrazit plný text záznamu

Carbinolamines, imines, and oxazolidines from fluorinated propranolol analogs. (19)F NMR and mass spectral characterization and evidence for formation as intermediates in cytochrome P450-catalyzed N-dealkylation

Autor: A L, Upthagrove, W L, Nelson

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(8)

Formation of carbinolamine, imine, and oxazolidines from the reactions of desisopropylpropranolol (5), its O-methyl ether (10), and 3-(1-naphthoxy)propylamine (11) with trifluoroacetone and trifluoroacetaldehyde methyl hemiacetal was investigated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::332b5fb950fe7a7a74076f9cf7b5b3cd
https://pubmed.ncbi.nlm.nih.gov/11454730

Zobrazit plný text záznamu

Mass spectral fragmentation pathways of propranolol related beta-fluorinated amines studied by electrospray and electron impact ionization

Autor: A L, Upthagrove, M, Hackett, W L, Nelson

Publikováno v: Rapid communications in mass spectrometry : RCM. 13(16)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83ac87d9b05399e109f4af014ff4cab5
https://pubmed.ncbi.nlm.nih.gov/10440986

Zobrazit plný text záznamu

Fragmentation pathways of selectively labeled uropranolol using electrospray ionization on an ion trap mass spectrometer and comparison with ions formed by electron impact

Autor: A L, Upthagrove, M, Hackett, W L, Nelson

Publikováno v: Rapid communications in mass spectrometry : RCM. 13(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::863e761c651c7943952fd8f4fb880ea1
https://pubmed.ncbi.nlm.nih.gov/10204247

Zobrazit plný text záznamu

Periodical

Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol analogs: metabolism by CYP1A2.

Autor: L, Upthagrove A, L, Nelson W

Publikováno v: Drug Metabolism and Disposition; November 2001, Vol. 29 Issue: 11 p1389-95, 7p

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání