Výsledky vyhledávání - "A L, Timkovskiĭ"

[Broadening of the organ specificity of the action of polynucleotide interferon inducers]

Autor: O A, Aksenov, G A, Platonova, A L, Timkovskiĭ

Publikováno v: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 44(9)

Interferon titers in the blood and brain of mice and their protection from the herpes virus were compared after the animal exposure to poly(G).poly(C) duplex, both native and modified with cis-diammine dichloroplatinum (II). It was shown that the dup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19f992fa90b6216c1dd62a69c06a26af
https://pubmed.ncbi.nlm.nih.gov/10511902

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[Antiviral activity of poly(A)-poly(U) duplexes modified with cis-diammine-dichloroplatinum (II)]

Autor: O A, Aksenov, G A, Platonova, A L, Timkovskiĭ

Publikováno v: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 44(6)

Polyribonucleotide duplex poly(A).poly(U) was modified with cis-diammine dichloroplatinum (II) (cis-DDP). It was shown that the antiinfluenza protective activity of the modified duplex in mice increased with the degree of modification (rb) rising up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09064c0f42a5f47400f6255a4e368414
https://pubmed.ncbi.nlm.nih.gov/10422572

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[Biological activity of the poly(G).poly(C) complex, modified by divalent platinum compounds]

Autor: O A, Aksenov, E A, Murina, E M, Kogan, G A, Platonova, N S, Sidorova, A L, Timkovskiĭ

Publikováno v: Voprosy virusologii. 40(2)

Modification of poly(G).poly(C) with cys-diaminodichloroplatinum (cys-DDP) at the level of rb = 0.02 increased the in vivo antiviral and interferon-inducing activity of the complex, in contrast to the data reported for complex poly(G).poly(C). Antiin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfec20e1b83f99051324e9e81efbeead
https://pubmed.ncbi.nlm.nih.gov/7762230

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[Analysis of defects in the structure of the complex poly(G).poly(C)]

Autor: A L, Timkovskiĭ, Z, Baltsarova, V, Brabets

Publikováno v: Molekuliarnaia biologiia. 28(5)

The concentration of free poly(C) in solution in the course of its interaction with poly(G) as well as in the presence of preformed complex poly(G).poly(C) was measured by differential pulse polarography (DPP) at a mercury dropping electrode. Poly(C)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8561006721422637c67576f82099ac6
https://pubmed.ncbi.nlm.nih.gov/7990824

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[Interrelationship between the chain length of poly-L-lysine and the degree of protection of polyribonucleotide interferon inducers from human blood nucleases]

Autor: M A, Surzhik, A E, Duks, N G, Diatlova, E A, Glazunov, G Ia, Feldmane, A L, Timkovskiĭ

Publikováno v: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 38(7)

The action of the human total blood serum on polynucleotide interferon inducers, larifan and ridostin (natural double-stranded RNAs) and poly(I).poly(C) (a double-stranded complex of synthetic polyribonucleotides) used both in the free state and in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::57c861dde1b34d401afc49bce361b729
https://pubmed.ncbi.nlm.nih.gov/8161271

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[Resistance of natural and synthetic polyribonucleotide inducers of interferon to human blood ribonucleases]

Autor: M A, Surzhik, N G, Diatlova, E A, Glazunov, A L, Timkovskiĭ, G P, Vlasov, N Iu, Kozhevnikova

Publikováno v: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 37(1)

The resistance of polyribonucleotide inductors of interferon to blood ribonucleases was studied. Blood resistance of larifan and ridostin in the free and shielded state as well as that of the complexes of poly(I)-poly(C) and poly(G)-poly(C) were also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::078a8e574fdcf586638acbe98dfe7671
https://pubmed.ncbi.nlm.nih.gov/1530353

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[Antiviral and interferonogenic activity of synthetic complexes of homopolyribonucleotides and complexes of homo- and heteropolyribonucleotides]

Autor: L M, Vil'ner, L M, Brodskaia, E M, Kogan, A L, Timkovskiĭ, N S, Sidorova

Publikováno v: Vestnik Akademii meditsinskikh nauk SSSR. (5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d67d06ba132f929b66d9e7b36d226e74
https://pubmed.ncbi.nlm.nih.gov/196451

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[Antiviral activity of the complexes obtained at different ratios of complementary homopolyribonucleotides]

Autor: A S, Novokhatskiĭ, E M, Kogan, A L, Timkovskiĭ

Publikováno v: Antibiotiki. 23(5)

Antiviral activity of the complexes of synthetic polyribonucleotides, i.e. poly (I).poly (C) and poly (G).poly (C) obtained at non-equimolar ratios of homopolymers was studied. The system of chick embryon fibroblasts and horse Venezuellan eguine ence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a6ee79f4ce1038fa347bacf18aab8763
https://pubmed.ncbi.nlm.nih.gov/655685

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[Evaluation of the size of the continuous poly(G) site necessary for the biological activity of the poly(G).poly(C) complex]

Autor: L M, Vil'ner, G A, Platonova, E M, Kogan, N S, Sidorov, A L, Timkovskiĭ

Publikováno v: Voprosy virusologii. 30(3)

On the basis of synthesis of a series of poly(G, A).poly(C) copolymers with changing G:A ratio from 15:1 to 90:1 and trials of their biological activity in comparison with poly(G).poly(C), the size of poly(G) in it was evaluated within the range of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f36cc035fb7e39770a07a733b59c9960
https://pubmed.ncbi.nlm.nih.gov/2996241

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