Sleep spindles across youth affected by schizophrenia or anti-N-methyl-D-aspartate-receptor encephalitis

Autor: Maria E. Dimitriades, Andjela Markovic, Silvano R. Gefferie, Ashura Buckley, David I. Driver, Judith L. Rapoport, Margherita Nosadini, Kevin Rostasy, Stefano Sartori, Agnese Suppiej, Salome Kurth, Maurizia Franscini, Susanne Walitza, Reto Huber, Leila Tarokh, Bigna K. Bölsterli, Miriam Gerstenberg

Publikováno v: Frontiers in Psychiatry, Vol 14 (2023)

BackgroundSleep disturbances are intertwined with the progression and pathophysiology of psychotic symptoms in schizophrenia. Reductions in sleep spindles, a major electrophysiological oscillation during non-rapid eye movement sleep, have been identi

Externí odkaz: https://doaj.org/article/5f79ee1738b34155827592693f78ed07

The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Autor: Khalid El Bairi, Harry R. Haynes, Elizabeth Blackley, Susan Fineberg, Jeffrey Shear, Sophia Turner, Juliana Ribeiro de Freitas, Daniel Sur, Luis Claudio Amendola, Masoumeh Gharib, Amine Kallala, Indu Arun, Farid Azmoudeh-Ardalan, Luciana Fujimoto, Luz F. Sua, Shi-Wei Liu, Huang-Chun Lien, Pawan Kirtani, Marcelo Balancin, Hicham El Attar, Prerna Guleria, Wenxian Yang, Emad Shash, I-Chun Chen, Veronica Bautista, Jose Fernando Do Prado Moura, Bernardo L. Rapoport, Carlos Castaneda, Eunice Spengler, Gabriela Acosta-Haab, Isabel Frahm, Joselyn Sanchez, Miluska Castillo, Najat Bouchmaa, Reena R. Md Zin, Ruohong Shui, Timothy Onyuma, Wentao Yang, Zaheed Husain, Karen Willard-Gallo, An Coosemans, Edith A. Perez, Elena Provenzano, Paula Gonzalez Ericsson, Eduardo Richardet, Ravi Mehrotra, Sandra Sarancone, Anna Ehinger, David L. Rimm, John M. S. Bartlett, Giuseppe Viale, Carsten Denkert, Akira I. Hida, Christos Sotiriou, Sibylle Loibl, Stephen M. Hewitt, Sunil Badve, William Fraser Symmans, Rim S. Kim, Giancarlo Pruneri, Shom Goel, Prudence A. Francis, Gloria Inurrigarro, Rin Yamaguchi, Hernan Garcia-Rivello, Hugo Horlings, Said Afqir, Roberto Salgado, Sylvia Adams, Marleen Kok, Maria Vittoria Dieci, Stefan Michiels, Sandra Demaria, Sherene Loi, The International Immuno-Oncology Biomarker Working Group

Publikováno v: npj Breast Cancer, Vol 7, Iss 1, Pp 1-17 (2021)

Abstract The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of pr

Externí odkaz: https://doaj.org/article/98d18f7227c34bcb8909cccb39302c30

Systemic Immune Dysregulation in Early Breast Cancer Is Associated With Decreased Plasma Levels of Both Soluble Co-Inhibitory and Co-Stimulatory Immune Checkpoint Molecules

Autor: Bernardo L. Rapoport, Helen C. Steel, Nomsa Hlatshwayo, Annette J. Theron, Pieter W. A. Meyer, Simon Nayler, Carol-Ann Benn, Teresa Smit, Luyanda L. I. Kwofie, Liezl Heyman, Ronald Anderson

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Breast cancer cells exploit the up-regulation or down-regulation of immune checkpoint proteins to evade anti-tumor immune responses. To explore the possible involvement of this mechanism in promoting systemic immunosuppression, the pre-treatment leve

Externí odkaz: https://doaj.org/article/86487d26257341118fa96a706e3a33f4

Elevated Levels of Soluble CTLA-4, PD-1, PD-L1, LAG-3 and TIM-3 and Systemic Inflammatory Stress as Potential Contributors to Immune Suppression and Generalized Tumorigenesis in a Cohort of South African Xeroderma Pigmentosum Patients

Autor: Mahlatse C. M. Kgokolo, Katherine Anderson, Shalate C. Siwele, Helen C. Steel, Luyanda L. I. Kwofie, Mike M. Sathekge, Pieter W. A. Meyer, Bernardo L. Rapoport, Ronald Anderson

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Xeroderma Pigmentosum (XP), an autosomal recessive disorder characterized by ultraviolet radiation-induced abnormalities of DNA excision and repair pathways is associated with early development of cutaneous cancers. Intracellular oxidative stress has

Externí odkaz: https://doaj.org/article/262f3bbc73be46c5bb3fa496f71abf77

Pulmonary Toxicities Associated With the Use of Immune Checkpoint Inhibitors: An Update From the Immuno-Oncology Subgroup of the Neutropenia, Infection & Myelosuppression Study Group of the Multinational Association for Supportive Care in Cancer

Autor: Bernardo L. Rapoport, Vickie R. Shannon, Tim Cooksley, Douglas B. Johnson, Lindsay Anderson, Ada G. Blidner, Gregory R. Tintinger, Ronald Anderson

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, with agents such as nivolumab, pembrolizumab, and cemiplimab targeting programmed cell death protein-1 (PD-1) and durvalumab, avelumab, and atezolizumab targe

Externí odkaz: https://doaj.org/article/407b43c0a26f43a19b522c1f1855c2df