Zobrazeno 1 - 10
of 78
pro vyhledávání: '"A L, Okorokov"'
Autor:
François Serra, Andrea Nieto-Aliseda, Lucía Fanlo-Escudero, Llorenç Rovirosa, Mónica Cabrera-Pasadas, Aleksey Lazarenkov, Blanca Urmeneta, Alvaro Alcalde-Merino, Emanuele M. Nola, Andrei L. Okorokov, Peter Fraser, Mariona Graupera, Sandra D. Castillo, Jose L. Sardina, Alfonso Valencia, Biola M. Javierre
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, we uncover the
Externí odkaz:
https://doaj.org/article/0a358ee1ea5c43e4a2c5658e8409ffd6
Publikováno v:
Спортивная медицина: наука и практика, Vol 13, Iss 2, Pp 39-45 (2023)
Objective: to assess the natural course of subclinical hypothyroidism in young athletes.Methods: In the prospective single-center uncontrolled study, data from 3,062 outpatient records of young athletes (members of the Russian national team) of both
Externí odkaz:
https://doaj.org/article/29b30ae97e364ea69a94671acdc31140
Publikováno v:
Спортивная медицина: наука и практика, Vol 13, Iss 1, Pp 80-87 (2023)
Ice-hockey combines intense physical activity at high speed with elements of power struggle. Testosterone is the main anabolic hormone, an increase in which during adolescence is associated with faster growth, increased muscle mass, physical strength
Externí odkaz:
https://doaj.org/article/d88e5895e4e54271a6ff079833e4369e
Autor:
Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the voltage-sensing domains, o
Externí odkaz:
https://doaj.org/article/ef7fee6301d340c5b67edc494cc4b801
Publikováno v:
Ожирение и метаболизм, Vol 19, Iss 2, Pp 142-147 (2022)
Background: Assessment of resting energy expenditure (REE) is necessary for the formation of a diet for obesity patients. The «gold standard» for assessment of resting energy expenditure (REE) is indirect respiratory calorimetry. Currently, bioimpe
Externí odkaz:
https://doaj.org/article/883dafdf98904560b35569a8c2405cda
Publikováno v:
Спортивная медицина: наука и практика, Vol 11, Iss 1, Pp 72-78 (2021)
There is no data on the prevalence of endocrine disorders in young elite athletes in Russia.Objective: to assess the prevalence of endocrine pathologies and their structure in children and adolescents involved in elite sport.Materials and methods: th
Externí odkaz:
https://doaj.org/article/4e62e7a198a84148870aa3287a940346
Publikováno v:
Сахарный диабет, Vol 23, Iss 6, Pp 523-531 (2021)
BACKGROUND: Incidence of Type 2 Diabetes Mellitus (T2DM) and associated dysglycemic conditions, increasing the risk of diabetes development, continues to rise worldwide, most notably due to ever-growing obesity rate. Early identification of the perso
Externí odkaz:
https://doaj.org/article/da76abd138234d12b455845f5dcdc919
Autor:
Vera V. Grinkevich, Aparna Vema, Karin Fawkner, Natalia Issaeva, Virginia Andreotti, Eleanor R. Dickinson, Elisabeth Hedström, Clemens Spinnler, Alberto Inga, Lars-Gunnar Larsson, Anders Karlén, Margareta Wilhelm, Perdita E. Barran, Andrei L. Okorokov, Galina Selivanova, Joanna E. Zawacka-Pankau
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Restoration of the p53 tumor suppressor for personalised cancer therapy is a promising treatment strategy. However, several high-affinity MDM2 inhibitors have shown substantial side effects in clinical trials. Thus, elucidation of the molecular mecha
Externí odkaz:
https://doaj.org/article/6e3200658e124c519165fca58876e250
Autor:
Pavel L. Okorokov, Alexey L. Kalinin, Natalia A. Strebkova, Maria A. Kareva, Olga V. Vasyukova, Valentina A. Peterkova, Olga B. Bezlepkina
Publikováno v:
Ожирение и метаболизм, Vol 17, Iss 3, Pp 249-256 (2020)
Background: Hypothalamic obesity often develops after surgical treatment of craniopharyngioma and is characterized by rapid weight gain, high frequency of metabolic disorders, body composition specificity and resistance to standard lifestyle modifica
Externí odkaz:
https://doaj.org/article/b9f9f0e4a487475db8f53ef4aae6b7b6
Autor:
Ana P. Luiz, Federico Iseppon, James J. Cox, John N. Wood, Jing Zhao, Sonia Santana-Varela, Yury D. Bogdanov, Andrei L. Okorokov, Samuel J. Gossage, Larissa de Clauser, Shengnan Li, Jane E. Sexton, Marta Alves-Simoes
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Somatosensation depends on primary sensory neurons of the trigeminal and dorsal root ganglia (DRG). Transcriptional profiling of mouse DRG sensory neurons has defined at least 18 distinct neuronal cell types. Using an advillin promoter, w
Externí odkaz:
https://doaj.org/article/f64ad67d3e6048f8af0b481f7da9b730