Zobrazeno 1 - 10
of 65
pro vyhledávání: '"A L, Maycock"'
Publikováno v:
Practice Periodical on Structural Design and Construction. 24
Construction operations such as hydrodemolition, diamond grinding, and grooving of concrete infrastructure generate large amounts of concrete residuals. These residuals can be slurry water ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f5c1bf1330dac82b7cdaa94fa703293
https://doi.org/10.1061/(asce)sc.1943-5576.0000447
https://doi.org/10.1061/(asce)sc.1943-5576.0000447
Autor:
Mark A. Hurley, Peter Zager, Mark Hebblewhite, Craig L. Maycock, Edward O. Garton, John R. Skalski, James W. Unsworth, Debra M. Montgomery
Publikováno v:
Wildlife Monographs. 178:1-33
Manipulating predator populations is often posed as a solution to depressed ungulate populations. However, predator—prey dynamics are complex and the effect on prey populations is often an interaction of predator life history, climate, prey density
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e535577290da8eef52d6707ce7daeab1
https://doi.org/10.1002/wmon.4
https://doi.org/10.1002/wmon.4
Autor:
Erin Gauntner, Alan L. Maycock, Virendra Kumar, Patrick J. Little, Michael Koblish, Erik Mansson, Diane L. DeHaven-Hudkins, Susan L. Gottshall, Robert N. DeHaven, Joel A. Cassel, Susan L. Greiner, Jeffrey D. Daubert, Deqi Guo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1091-1095
A series of 3-substituted analogs (3) of the parent kappa agonist, 1, were prepared to limit access to the central nervous system. With the exception of compound 3j, all other compounds bound to the human kappa opioid receptor with high affinity (K(i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3db90e39df13c434333ff00c6b6a94c
https://doi.org/10.1016/j.bmcl.2004.12.018
https://doi.org/10.1016/j.bmcl.2004.12.018
Autor:
An-Chih Chang, Virendra Kumar, Luz Cortes-Burgos, Jeffrey D. Daubert, Joel A. Cassel, Erik Mansson, Alan L. Maycock, Diane L. DeHaven-Hudkins, Michael Anthony Marella, Susan L. Gottshall, Robert N. DeHaven
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2567-2570
Analogues of the kappa (kappa) opioid receptor agonist, ICI 199441, were prepared. Ki values for these analogues at the cloned human kappa opioid receptor ranged from 0.058 to 25 nM. Trifluoromethylaryl derivatives were potent analgesics when adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43acbb620e2b032602262fe67ade03e0
https://doi.org/10.1016/s0960-894x(00)00519-9
https://doi.org/10.1016/s0960-894x(00)00519-9
Autor:
C. S. Burgey, Liesch J, Shrenik K. Shah, David W. Kuo, Renee M. Chabin, B G Green, Alan L. Maycock, Gale P, Sander G. Mills, Dennis J. Underwood
Publikováno v:
Biochemistry. 34:14331-14343
The monocyclic beta-lactams reported by Knight et al. [Knight, W. B., et al. (1992) Biochemistry 31, 8160; Chabin, R., et al. (1993) Biochemistry 32, 8970] as inhibitors of human leucocyte elastase (HLE) produce stable HLE-inhibitor complexes that sl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21c8c4964ff8ea7e572ee6a061a7fee
https://doi.org/10.1021/bi00044a010
https://doi.org/10.1021/bi00044a010
Autor:
Robert J. Gordan, Chakrapani Subramanyam, W. Mark Eickhoff, Marion L. Drozd, David T. Robinson, Edward D. Pagani, Judith A. Johnson, Dennis J. Hlasta, Catherine A. Franke, Ranjit Ch Desai, Paul J. Silver, Alan L. Maycock, John F. Newton, Edward W. Ferguson, Dunlap Richard Paul, Eugene R. Baizman
Publikováno v:
Drug Development Research. 34:306-316
The proteolytic activity of human neutrophil elastase (HNE) has been implicated in a number of pulmonary diseases. We report on the activity of an orally bioavailable, selective HNE inhibitor, WIN 63759 [6-methoxy-4-(1-methylethy)-3-oxo-1,2-benzisoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b219826e23c3c6d5355f8c72f702212f
https://doi.org/10.1002/ddr.430340308
https://doi.org/10.1002/ddr.430340308
Autor:
Dennis J. Hlasta, Virendra Kumar, Kenneth C. Cundy, Malcolm R. Bell, Chakrapani Subramanyam, Alan L. Maycock, Ranjit C. Desai, E. Ferguson, A. J. Mura, C. A. Franke, Dunlap Richard Paul, Anne G. Rowlands, Robert J. Gordon, Shari L. Eiff, John J. Court
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:331-336
The lead compound for this SAR study, benzisothiazolone 1a, was a 15 nM inhibitor of HLE, but was unstable in human blood ( t 1 2 min). The introduction of lipophilic substituents at the R4-position such as ethyl or isopropyl and modulation of the el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea1155374a07808b26361338d78aa314
https://doi.org/10.1016/0960-894x(95)00030-w
https://doi.org/10.1016/0960-894x(95)00030-w
Autor:
Alex L. Harris, Todd L. Graybill, Alan L. Maycock, Schmidt Stanley J, I. Kelly Osifo, Jill S. Gregory, Roland E. Dolle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:393-398
Z-Leu-Arg-(7-methoxynaphthyl)amide (1) is a substrate for calpain I. The specificity constant for 1 ( k cat K m = 1405 ± 40 M−1s−1) is 10x greater than for any previously reported fluorogenic substrate. Using this substrate, a sensitive, continu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73c075bacdd43011abda6fc468651b75
https://doi.org/10.1016/0960-894x(95)00042-r
https://doi.org/10.1016/0960-894x(95)00042-r
Autor:
Richard A. Mumford, H. Weston, Alan L. Maycock, Shrenik K. Shah, Bonnie M. Ashe, Karen A. Brause, James B. Doherty, G. O. Chandler, Paul E. Finke
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2295-2298
The synthesis of the four stereoisomers of 3-ethyl-4-[(4-carboxyphenyl)oxy]-1-[[(phenylmethyl)amino]carbonyl]-2-azetidinone ( 1 ) starting from either D or L-aspartic acid is reported. The trans (3R,4R) isomer 7a , prepared from L-aspartic acid had t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b75117a32415cd53baebdaf78cd7344e
https://doi.org/10.1016/s0960-894x(01)80942-2
https://doi.org/10.1016/s0960-894x(01)80942-2
Autor:
Shrenik K. Shah, Pam S. Dellea, Paul E. Finke, James B. Doherty, Kevan R. Thompson, Karen M. Hand, D. S. Fletcher, Alan L. Maycock, Bonnie M. Ashe, Mary Ellen Dahlgren
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2283-2288
Penicillin amides substituted at C-6 with either an α- or β-trifluoroacetamido or an α-alkoxy functionality are reported as human leukocyte elastase (HLE) inhibitors. The structure activity relations for these derivatives are discussed and compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28429214fb69091dd791b0ba82100a8e
https://doi.org/10.1016/s0960-894x(01)80940-9
https://doi.org/10.1016/s0960-894x(01)80940-9