Výsledky vyhledávání - "A L, Feldhaus"

A Female-Specific Role for Calcitonin Gene-Related Peptide (CGRP) in Rodent Pain Models

Autor: Candler Paige, Isabel Plasencia-Fernandez, Moeno Kume, Melina Papalampropoulou-Tsiridou, Louis-Etienne Lorenzo, Eric T. David, Lucy He, Galo L. Mejia, Christopher Driskill, Francesco Ferrini, Andrew L. Feldhaus, Leon F. Garcia-Martinez, Armen N. Akopian, Yves De Koninck, Gregory Dussor, Theodore J. Price

Publikováno v: J Neurosci

We aimed to investigate a sexually dimorphic role of calcitonin gene-related peptide (CGRP) in rodent models of pain. Based on findings in migraine where CGRP has a preferential pain-promoting effect in female rodents, we hypothesized that CGRP antag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b99aaaa249bfec37f600d2341ae392
https://pubmed.ncbi.nlm.nih.gov/35058371

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Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors

Publikováno v: Osteoarthritis and Cartilage. 10:308-320

Objective The aim of this study was to examine the effects of recombinant human Fgf18 on chondrocyte proliferation and matrix production in vivo and in vitro . In addition, the expressions of Fgf18 and Fgf receptors ( Fgfr ) in adult human articular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18df2c0e430123c82dd9b5ed44329996
https://doi.org/10.1053/joca.2002.0514

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ALD1613, A Novel Long-Acting Monoclonal Antibody to Control ACTH-Driven Pharmacology

Publikováno v: Endocrinology. :en.2016-1455

Adrenocorticotropic hormone (ACTH) is the primary regulator of adrenal glucocorticoid production. Elevated levels of ACTH play a critical role in disease progression in several indications, including congenital adrenal hyperplasia and Cushing disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e92f8710d76777d9c97d6e9609dbe5a
https://doi.org/10.1210/en.2016-1455

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Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain

Autor: Mark F. Maurer, Darrell C. Conklin, Theodore E. Whitmore, Susan D. Holderman, Andrew L. Feldhaus

Publikováno v: Gene. 249:91-98

The sequence of the ubiquitin protein is highly conserved between species and has facilitated the cloning of numerous ubiquitin-like proteins. In the present study, we report the cloning of the cDNA for human ubiquilin 3 (UBQLN3). The deduced amino a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae778a97f43177cb40e9721a30fdb506
https://doi.org/10.1016/s0378-1119(00)00122-0

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Molecular cloning, chromosome mapping and characterization of a testis-specific cystatin-like cDNA, cystatin T

Autor: Mark F. Maurer, James L. Holloway, Andrew L. Feldhaus, Kimberly E. Shoemaker, Theodore E. Whitmore

Publikováno v: Gene. 245:103-108

The cystatin superfamily of cysteine proteinase inhibitors consists of three major families. In the present study, we report the cloning of the cDNA for mouse cystatin T, which is related to family 2 cystatins. The deduced amino acid sequence of cyst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8dd411aa980d5db44af19e6990eb5c8
https://doi.org/10.1016/s0378-1119(00)00030-5

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Expression of Chimeric Granulocyte-Macrophage Colony-Stimulating Factor/Interleukin 2 Receptors in Human Cytotoxic T Lymphocyte Clones Results in Granulocyte-Macrophage Colony-Stimulating Factor-Dependent Growth

Autor: Stephen D. Lupton, Lawrence S. Evans, Stanley R. Riddell, Andrew L. Feldhaus, Philip D. Greenberg, Brad H. Nelson, Pamela R. Witte, Lori A. Jones

Publikováno v: Human Gene Therapy. 10:1941-1951

Adoptive immunotherapy with ex vivo-expanded antigen-specific cytotoxic T lymphocytes (CTLs) has been shown to clear viral infections and eliminate tumors in murine models. Clinical trials have also reported promising data for the use of adoptive imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427f15f572130f0f3a1d3b77ece97bf7
https://doi.org/10.1089/10430349950017301

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The mouse CD69 gene. Structure, expression, and mapping to the NK gene complex

Autor: S F Ziegler, S D Levin, L Johnson, N G Copeland, D J Gilbert, N A Jenkins, E Baker, G R Sutherland, A L Feldhaus, F Ramsdell

Publikováno v: The Journal of Immunology. 152:1228-1236

CD69 is a rapidly induced T cell activation Ag that is also expressed in an inducible fashion on cells of most, if not all, hematopoietic lineages. Molecular cloning has shown that CD69 is a type II membrane glycoprotein that is a member of the C-typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea1e4781e9acec93a428ce58622b9c01
https://doi.org/10.4049/jimmunol.152.3.1228

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Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation

Autor: Harinder Singh, A. L. Feldhaus, K. L. Arvin, Christopher A. Klug

Publikováno v: The EMBO Journal. 12:2763-2772

The Oct-2 protein is a tissue-specific POU-homeodomain transcription factor. It has been considered to represent a developmental regulator of immunoglobulin gene expression by virtue of its interaction with a functionally essential octamer element fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82d80c648eaa8da1eae370e244ded2a
https://doi.org/10.1002/j.1460-2075.1993.tb05937.x

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Regulation and a Possible Stage-Specific Function of Oct-2 during Pre-B-Cell Differentiation

Autor: C H Sibley, A L Feldhaus, Linda D. Rhodes, J W Rooney, C L Miller, Harinder Singh

Publikováno v: Scopus-Elsevier

The Oct-2 gene appears to encode a developmental regulator of immunoglobulin gene transcription. We demonstrate that the Oct-2 gene is expressed at low levels in a variety of transformed pre-B-cell lines and is induced specifically in these cells by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d045d8dff1cd31d63ea78a9a65b57e14
https://doi.org/10.1128/mcb.11.10.4885-4894.1991

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Use of Adenovirus-Mediated Gene Transfer to Facilitate Biological Annotation of Novel Genes

Autor: Steven D. Hughes, Jeff L. Ellsworth, Andrew L. Feldhaus

Publikováno v: Cancer Drug Discovery and Development ISBN: 9781588294258

As part of a large program of gene annotation, use of adenovirus-mediated gene transfer facilitated rapid progress in the functional evaluation of more than 100 genes. Localized or systemic exposure to gene products expressed by adenovirus-transduced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f5d231565b72d948a3fdc9614b00eee
https://doi.org/10.1385/1-59259-893-5:287

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