Zobrazeno 1 - 10
of 1 033
pro vyhledávání: '"A L, Cohn"'
Autor:
Siddhi Ramesh, Emma Dyer, Monica Pomaville, Kristina Doytcheva, James Dolezal, Sara Kochanny, Rachel Terhaar, Casey J. Mehrhoff, Kritika Patel, Jacob Brewer, Benjamin Kusswurm, Arlene Naranjo, Hiroyuki Shimada, Nicole A. Cipriani, Aliya N. Husain, Peter Pytel, Elizabeth A. Sokol, Susan L. Cohn, Rani E. George, Alexander T. Pearson, Mark A. Applebaum
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-6 (2024)
Abstract A deep learning model using attention-based multiple instance learning (aMIL) and self-supervised learning (SSL) was developed to perform pathologic classification of neuroblastic tumors and assess MYCN-amplification status using H&E-stained
Externí odkaz:
https://doaj.org/article/3ee6eb5342a14a0d87b21a668f03f699
Autor:
Monica Pomaville, Mohansrinivas Chennakesavalu, Pingluan Wang, Zhiwei Jiang, Hui-Lung Sun, Peizhe Ren, Ryan Borchert, Varsha Gupta, Chang Ye, Ruiqi Ge, Zhongyu Zhu, Mallory Brodnik, Yuhao Zhong, Kelley Moore, Helen Salwen, Rani E. George, Malgorzata Krajewska, Alexandre Chlenski, Mark A. Applebaum, Chuan He, Susan L. Cohn
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114165- (2024)
Summary: The N6-methyladenosine (m6A) RNA modification is an important regulator of gene expression. m6A is deposited by a methyltransferase complex that includes methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14). High levels
Externí odkaz:
https://doaj.org/article/b70135c60c274c8db78ac7b2b49f0621
Autor:
Takayuki Yoshino, Josep Tabernero, Jin Yao, Amit Mahipal, Eric Chen, Heinz-Josef Lenz, Aparna Parikh, Timothy Larson, Dustin Deming, David R Spigel, Allen L Cohn, Mark Kochenderfer, Elena Elez, Spencer H Shao, Regan Holdridge, Antonio Ucar, Dana Cullen, Edwina Baskin-Bey, Tong Kang, Amy B Hammell
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)
Background Standard first-line therapies for metastatic colorectal cancer (mCRC) include fluoropyrimidine-containing regimens with oxaliplatin and/or irinotecan and a biologic agent. Immunotherapy may enhance antitumor activity in combination with st
Externí odkaz:
https://doaj.org/article/4248b125094a414a9758f28ab9189376
Autor:
Razvan Cristescu, Andrey Loboda, Robert Orlowski, Vicky Makker, Matthew H Taylor, Carol Aghajanian, Petar Jelinic, Lea Dutta, Allen L Cohn, Marcia S Brose, Christopher Di Simone, Zhu Alexander Cao, Leah Suttner, Junji Matsui, Corina E Dutcus, Yukinori Minoshima, Mark J Messing
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)
Background Lenvatinib plus pembrolizumab demonstrated clinically meaningful benefit in patients with previously treated advanced endometrial carcinoma in Study 111/KEYNOTE-146 (NCT02501096). In these exploratory analyses from this study, we evaluated
Externí odkaz:
https://doaj.org/article/1aba98f370d441fabd9fdd926cef1538
Autor:
Mohansrinivas Chennakesavalu, Caileigh Pudela, Mark A. Applebaum, Sang Mee Lee, Yan Che, Arlene Naranjo, Julie R. Park, Samuel L. Volchenboum, Tara O. Henderson, Susan L. Cohn, Ami V. Desai
Publikováno v:
EJC Paediatric Oncology, Vol 2, Iss , Pp 100022- (2023)
Background: Racial/ethnic survival disparities in neuroblastoma were first reported more than a decade ago. We sought to investigate if these disparities have persisted with current era therapy. Methods: Two patient cohorts were identified in the Int
Externí odkaz:
https://doaj.org/article/0884887593ac4022bd8dab8a00e8d3e1
Autor:
Anastasia E. Hains, Sakshi Uppal, John Z. Cao, Helen R. Salwen, Mark A. Applebaum, Susan L. Cohn, Lucy A. Godley
Publikováno v:
Epigenetics, Vol 17, Iss 13, Pp 2056-2074 (2022)
Ten-Eleven-Translocation 5-methylcytosine dioxygenases 1–3 (TET1-3) convert 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC), using oxygen as a co-substrate. Contrary to expectations, hypoxia induces 5-hmC gains in MYCN-amplified neuroblastoma (
Externí odkaz:
https://doaj.org/article/46684909df9349bab0c0b5b0bbd13c9a
Autor:
Marwan Fakih, Kanwal Pratap Singh Raghav, David Z. Chang, Tim Larson, Allen L. Cohn, Timothy K. Huyck, David Cosgrove, Joseph A. Fiorillo, Rachel Tam, David D'Adamo, Neelesh Sharma, Barbara J. Brennan, Ying A. Wang, Sabine Coppieters, Hong Zebger-Gong, Anke Weispfenning, Henrik Seidel, Bart A. Ploeger, Udo Mueller, Carolina Soares Viana de Oliveira, Andrew Scott Paulson
Publikováno v:
EClinicalMedicine, Vol 58, Iss , Pp 101917- (2023)
Summary: Background: Anti-programmed cell death protein 1 antibodies plus multikinase inhibitors have shown encouraging activity in several tumour types, including colorectal cancer. This study assessed regorafenib plus nivolumab in patients with mic
Externí odkaz:
https://doaj.org/article/607bb200b67a4b90be60f4ef3e49d300
Autor:
M. Peluso, S. Serrano-Villar, A. Gala, P. Bacchetti, C. Digermanio, L. Cohn, P. Hunt, G. Laird, S. Pillai, S. Deeks
Publikováno v:
Journal of Virus Eradication, Vol 8, Iss , Pp 100207- (2022)
Externí odkaz:
https://doaj.org/article/bdd27d75a7d74fb3a11eee23fd258f1e
Autor:
Ami V. Desai, Andrew L. Gilman, Mehmet Fevzi Ozkaynak, Arlene Naranjo, Wendy B. London, Sheena C. Tenney, Mitchell Diccianni, Jacquelyn A. Hank, Marguerite T. Parisi, Barry L. Shulkin, Malcolm Smith, Jeffrey A. Moscow, Hiroyuki Shimada, Katherine K. Matthay, Susan L. Cohn, John M. Maris, Rochelle Bagatell, Paul M. Sondel, Julie R. Park, Alice L. Yu
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 40(35)
PURPOSEPostconsolidation immunotherapy including dinutuximab, granulocyte-macrophage colony-stimulating factor, and interleukin-2 improved outcomes for patients with high-risk neuroblastoma enrolled on the randomized portion of Children's Oncology Gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a59f18126714f9522dd294525fd001
https://pubmed.ncbi.nlm.nih.gov/35839426
https://pubmed.ncbi.nlm.nih.gov/35839426
Autor:
Ami V Desai, Stefani Spranger, Thomas F Gajewski, Yuanyuan Zha, Jason J Luke, Peter Pytel, Kyle Hernandez, Samuel L Volchenboum, Susan L Cohn
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background Tumor-infiltrating CD8+ T cells and neoantigens are predictors of a favorable prognosis and response to immunotherapy with checkpoint inhibitors in many types of adult cancer, but little is known about their role in pediatric malignancies.
Externí odkaz:
https://doaj.org/article/b260b4d6e43c4d658b87dc58bb5c263c