Zobrazeno 1 - 10
of 11 001
pro vyhledávání: '"A Kouba"'
Autor:
Kouba, Petr, Planas-Iglesias, Joan, Damborsky, Jiri, Sedlar, Jiri, Mazurenko, Stanislav, Sivic, Josef
Generative machine learning models are increasingly being used to design novel proteins for therapeutic and biotechnological applications. However, the current methods mostly focus on the design of proteins with a fixed backbone structure, which lead
Externí odkaz:
http://arxiv.org/abs/2412.18275
Autor:
Sana Kouba, Nicolas Demaurex
Publikováno v:
Chronic Diseases and Translational Medicine, Vol 10, Iss 4, Pp 263-280 (2024)
Abstract Alterations in cellular calcium (Ca2+) signals have been causally associated with the development and progression of human cancers. Cellular Ca2+ signals are generated by channels, pumps, and exchangers that move Ca2+ ions across membranes a
Externí odkaz:
https://doaj.org/article/12e378082adb4fdab9f70b78d6768e72
Autor:
Bushuiev, Anton, Bushuiev, Roman, Kouba, Petr, Filkin, Anatolii, Gabrielova, Marketa, Gabriel, Michal, Sedlar, Jiri, Pluskal, Tomas, Damborsky, Jiri, Mazurenko, Stanislav, Sivic, Josef
Discovering mutations enhancing protein-protein interactions (PPIs) is critical for advancing biomedical research and developing improved therapeutics. While machine learning approaches have substantially advanced the field, they often struggle to ge
Externí odkaz:
http://arxiv.org/abs/2310.18515
Self-excited systems (SES) arise in numerous applications, such as fluid-structure interaction, combustion, and biochemical systems. In support of system identification and digital control of SES, this paper analyzes discrete-time Lur'e models with a
Externí odkaz:
http://arxiv.org/abs/2307.03851
Autor:
Nicole E. Speck, Julia Stoffel, Séverin Wendelspiess, Christian Appenzeller-Herzog, Kristin M. Schaefer, Loraine P. Kouba, Florian Rüter, Céline Montavon, Viola Heinzelmann-Schwarz, Martin D. Haug, Dirk J. Schaefer, Tarek Ismail, Elisabeth A. Kappos
Publikováno v:
Current Oncology, Vol 31, Iss 10, Pp 6300-6313 (2024)
Background: Patient-reported outcome measures (PROMs) have gained increased importance in assessing outcomes after reconstructive surgery. This also applies to the reconstruction of vulvoperineal defects after resection of gynecological or colorectal
Externí odkaz:
https://doaj.org/article/1478f41b990a45709ca0281ec4a9f688
Autor:
Tomáš Kovaľ, Nabajyoti Borah, Petra Sudzinová, Barbora Brezovská, Hana Šanderová, Viola Vaňková Hausnerová, Alena Křenková, Martin Hubálek, Mária Trundová, Kristýna Adámková, Jarmila Dušková, Marek Schwarz, Jana Wiedermannová, Jan Dohnálek, Libor Krásný, Tomáš Kouba
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Mycobacterial HelD is a transcription factor that recycles stalled RNAP by dissociating it from nucleic acids and, if present, from the antibiotic rifampicin. The rescued RNAP, however, must disengage from HelD to participate in subsequent r
Externí odkaz:
https://doaj.org/article/b4ae507a61d547bd9ec5f46e0019e458
Publikováno v:
Environmental Sciences Europe, Vol 36, Iss 1, Pp 1-12 (2024)
Abstract Biological invasions pose a global challenge, threatening both biodiversity and human well-being. Projections suggest that as invasions increase, the financial costs associated with management and the ecological harm they cause will also esc
Externí odkaz:
https://doaj.org/article/e7f0525dafb84e10996fc73ac29dcbdd
Autor:
Ondřej Bulvas, Zdeněk Knejzlík, Jakub Sýs, Anatolij Filimoněnko, Monika Čížková, Kamila Clarová, Dominik Rejman, Tomáš Kouba, Iva Pichová
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Allosteric regulation of inosine 5′-monophosphate dehydrogenase (IMPDH), an essential enzyme of purine metabolism, contributes to the homeostasis of adenine and guanine nucleotides. However, the precise molecular mechanism of IMPDH regulat
Externí odkaz:
https://doaj.org/article/8cabb055440b47878510600bec877241
Autor:
Frank I. Jackson, DO, Insaf Kouba, MD, Natalie Meirowitz, MD, Nathan A. Keller, MD, Luis A. Bracero, MD, Matthew J. Blitz, MD, MBA
Publikováno v:
AJOG Global Reports, Vol 4, Iss 4, Pp 100402- (2024)
Background: Prior studies evaluating the relationship between psychopharmacotherapy (PPT), and postpartum hemorrhage (PPH) have yielded inconsistent findings. Clarifying this potential relationship is important for effective counseling and risk strat
Externí odkaz:
https://doaj.org/article/0b25f3c944414555b67cc56c5406ed0e
Autor:
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Ilen Röhe, Katerina Theodoridou, Gabriele Aquilina, Kettil Svensson, Davor Želježić, Jaume Galobart, Orsolya Holczknecht, Maria Vittoria Vettori, Fabiola Pizzo
Publikováno v:
EFSA Journal, Vol 22, Iss 11, Pp n/a-n/a (2024)
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety of a feed additive consisting of vitamin B2/riboflavin p
Externí odkaz:
https://doaj.org/article/083b7041d6db47949516abd13785f9b1