Zobrazeno 1 - 10
of 167
pro vyhledávání: '"A Khoshnan"'
Autor:
Khoshnan, Ali1 (AUTHOR) khoshnan@usc.edu
Publikováno v:
Journal of Huntington's Disease. 2024, Vol. 13 Issue 2, p133-147. 15p.
Autor:
Anjalika Chongtham, Jung Hyun Yoo, Theodore M. Chin, Ngozi D. Akingbesote, Ainul Huda, J. Lawrence Marsh, Ali Khoshnan
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/c6bcdb4a1ddb44878b66ea04652d0e36
Autor:
Anjalika Chongtham, Jung Hyun Yoo, Theodore M. Chin, Ngozi D. Akingbesote, Ainul Huda, J. Lawrence Marsh, Ali Khoshnan
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Changes in the composition of gut microbiota are implicated in the pathogenesis of several neurodegenerative disorders. Here, we investigated whether gut bacteria affect the progression of Huntington’s disease (HD) in transgenic Drosophila melanoga
Externí odkaz:
https://doaj.org/article/f4cf075b3b0a451f98fb0f28d30fa251
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103771- (2022)
Summary: Huntington disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Metabolic changes are associated with HD progression, but underlying mechanisms are not fully known. As the IKKβ/NF-κB p
Externí odkaz:
https://doaj.org/article/0e2914dd1fd24046b864679ec4736f8b
Autor:
Anjalika Chongtham, J. Mario Isas, Nitin K. Pandey, Anoop Rawat, Jung Hyun Yoo, Tara Mastro, Mary B. Kennedy, Ralf Langen, Ali Khoshnan
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105517- (2021)
Huntington’s disease (HD) is a genetically inherited neurodegenerative disorder caused by expansion of a polyglutamine (polyQ) repeat in the exon-1 of huntingtin protein (HTT). The expanded polyQ enhances the amyloidogenic propensity of HTT exon 1
Externí odkaz:
https://doaj.org/article/b14f1f67bf2e4d5bac793d3277f76d60
Autor:
Franziska Schindler, Nicole Praedel, Nancy Neuendorf, Severine Kunz, Sigrid Schnoegl, Michael A. Mason, Bridget A. Taxy, Gillian P. Bates, Ali Khoshnan, Josef Priller, Jan Grimm, Marcel Maier, Annett Boeddrich, Erich E. Wanker
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The deposition of mutant huntingtin (mHTT) protein aggregates in neurons of patients is a pathological hallmark of Huntington’s disease (HD). Previous investigations in cell-free and cell-based disease models showed mHTT exon-1 (mHTTex1) fragments
Externí odkaz:
https://doaj.org/article/39b7832b713b418b99c771d5d66fad70
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2002 Jan . 99(2), 1002-1007.
Externí odkaz:
https://www.jstor.org/stable/3057680
Akademický článek
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Autor:
Ali Khoshnan, Paul H. Patterson
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 2, Pp 305-311 (2011)
The IκB kinase β (IKKβ) is a prominent regulator of neuroinflammation, which is implicated in the pathogenesis of Huntington's disease (HD). Inflammatory mediators accumulate in the serum and CNS of premanifest and manifest HD patients, and cytoki
Externí odkaz:
https://doaj.org/article/ac98a0eec6e941dcb75d9dc2ee662195
Autor:
Thompson, Leslie Michels, Aiken, Charity T., Kaltenbach, Linda S., Agrawal, Namita, Illes, Katalin, Khoshnan, Ali, Martinez-Vincente, Marta, Arrasate, Montserrat, O'Rourke, Jacqueline Gire, Khashwji, Hasan, Lukacsovich, Tamas, Zhu, Ya-Zhen, Lau, Alice L., Massey, Ashish, Hayden, Michael R., Zeitlin, Scott O., Finkbeiner, Steven, Green, Kim N., LaFerla, Frank M., Bates, Gillian, Huang, Lan, Patterson, Paul H., Lo, Donald C., Cuervo, Ana Maria, Marsh, J. Lawrence, Steffan, Joan S.
Publikováno v:
The Journal of Cell Biology, 2009 Dec . 187(7), 1083-1099.
Externí odkaz:
https://www.jstor.org/stable/20618412