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Akademický článek

Control of acute myeloid leukemia and generation of immune memory in vivo using AMV564, a bivalent bispecific CD33 x CD3 T cell engager.

Autor: Linda G Eissenberg, Julie K Ritchey, Michael P Rettig, Dilan A Patel, Kiran Vij, Feng Gao, Victoria Smith, Tae H Han, John F DiPersio

Publikováno v: PLoS ONE, Vol 19, Iss 5, p e0300174 (2024)

Off-the-shelf immunotherapeutics that suppress tumor growth and provide durable protection against relapse could enhance cancer treatment. We report preclinical studies on a CD33 x CD3 bivalent bispecific diabody, AMV564, that not only suppresses tum

Externí odkaz: https://doaj.org/article/8c314f5537e44cf58287f597f11ec364

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Akademický článek

A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity

Autor: Miriam Y. Kim, Reyka Jayasinghe, Jessica M. Devenport, Julie K. Ritchey, Michael P. Rettig, Julie O’Neal, Karl W. Staser, Krista M. Kennerly, Alun J. Carter, Feng Gao, Byung Ha Lee, Matthew L. Cooper, John F. DiPersio

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Chimeric antigen receptor T cells represent a breakthrough treatment in hematologic malignancies, but insufficient level of cytotoxicity and persistence of T cells might compromise success. Authors show here that a recombinant long acting form of int

Externí odkaz: https://doaj.org/article/57d87d554b9b4960b607af4e9bf488c8

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Akademický článek

CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy

Autor: Miriam Y. Kim, Matthew L. Cooper, Miriam T. Jacobs, Julie K. Ritchey, Julia Hollaway, Todd A. Fehniger, John F. DiPersio

Publikováno v: JCI Insight, Vol 6, Iss 16 (2021)

Targeting T cell malignancies with universal CD7-targeting chimeric antigen receptor T cells (UCART7) can lead to profound immune deficiency due to loss of normal T and NK cells. While a small population of endogenous CD7– T cells exists, these cel

Externí odkaz: https://doaj.org/article/26744d5e00b8483a8c866070dcd5c761

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