Zobrazeno 1 - 10
of 59
pro vyhledávání: '"A K Blakney"'
Autor:
Paul K. Kitandwe, Paul Rogers, Kai Hu, Owen Nayebare, Anna K. Blakney, Paul F. McKay, Pontiano Kaleebu, Robin J. Shattock
Publikováno v:
Vaccines, Vol 12, Iss 10, p 1088 (2024)
Rift Valley fever (RVF) is a mosquito-borne viral zoonosis that causes high fetal and neonatal mortality rates in ruminants and sometimes severe to fatal complications like encephalitis and hemorrhagic fever in humans. There is no licensed RVF vaccin
Externí odkaz:
https://doaj.org/article/7cf85b1d32ae42a9b8fc69a8c7bda419
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Self-amplifying messenger ribonucleic acid (saRNA) provides extended expression of genes of interest by encoding an alphavirus-derived RNA replicase and thus is 2–3 times larger than conventional messenger RNA. However, quality assessment
Externí odkaz:
https://doaj.org/article/f0197f1cfe464e06845870c0304898c4
Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines
Autor:
John S. Tregoning, David C. Stirling, Ziyin Wang, Katie E. Flight, Jonathan C. Brown, Anna K. Blakney, Paul F. McKay, Robert F. Cunliffe, Valarmathy Murugaiah, Christopher B. Fox, Mitchell Beattie, Ying K. Tam, Cecilia Johansson, Robin J. Shattock
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 29-42 (2023)
To be effective, RNA vaccines require both in situ translation and the induction of an immune response to recruit cells to the site of immunization. These factors can pull in opposite directions with the inflammation reducing expression of the vaccin
Externí odkaz:
https://doaj.org/article/0d6a34fafa0d4648b2111c1434bf06b4
Autor:
Alexandra J. Spencer, Paul F. McKay, Sandra Belij-Rammerstorfer, Marta Ulaszewska, Cameron D. Bissett, Kai Hu, Karnyart Samnuan, Anna K. Blakney, Daniel Wright, Hannah R. Sharpe, Ciaran Gilbride, Adam Truby, Elizabeth R. Allen, Sarah C. Gilbert, Robin J. Shattock, Teresa Lambe
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Heterologous vaccination regimens for COVID-19 could be useful for example if there is a shortage of one vaccine type. Here, Spencer et al. show that heterologous vaccination with a self-amplifying RNA vaccine and an adenoviral vectored vaccine perfo
Externí odkaz:
https://doaj.org/article/b9635c93599e4d14abcf385c2298f08d
Autor:
Damien van de Berg, Zoltán Kis, Carl Fredrik Behmer, Karnyart Samnuan, Anna K. Blakney, Cleo Kontoravdi, Robin Shattock, Nilay Shah
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract Rapid-response vaccine production platform technologies, including RNA vaccines, are being developed to combat viral epidemics and pandemics. A key enabler of rapid response is having quality-oriented disease-agnostic manufacturing protocols
Externí odkaz:
https://doaj.org/article/07c8cff71bf445a6a6254505e668c398
Autor:
Kai Hu, Paul F. McKay, Karnyart Samnuan, Adrian Najer, Anna K. Blakney, Junyi Che, Gwen O'Driscoll, Martina Cihova, Molly M. Stevens, Robin J. Shattock
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 3, Pp n/a-n/a (2022)
Abstract A vaccine antigen, when launched as DNA or RNA, can be presented in various forms, including intracellular, secreted, membrane‐bound, or on extracellular vesicles (EVs). Whether an antigen in one or more of these forms is superior in immun
Externí odkaz:
https://doaj.org/article/c597076c7d2d40ebbde634f539a11f55
Autor:
Paul F. McKay, Kai Hu, Anna K. Blakney, Karnyart Samnuan, Jonathan C. Brown, Rebecca Penn, Jie Zhou, Clément R. Bouton, Paul Rogers, Krunal Polra, Paulo J. C. Lin, Christopher Barbosa, Ying K. Tam, Wendy S. Barclay, Robin J. Shattock
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Here, the authors develop a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle as a vaccine candidate and show induction of neutralization antibody titers in mice that are comparable to titers in conval
Externí odkaz:
https://doaj.org/article/d121c83855b64dc7847d5eded42ee84e
Publikováno v:
Drug Delivery, Vol 24, Iss 1, Pp 582-590 (2017)
Composite delivery systems where drugs are electrospun in different layers and vary the drug stacking-order are posited to affect bioavailability. We evaluated how the formulation characteristics of both burst- and sustained-release electrospun fiber
Externí odkaz:
https://doaj.org/article/1b4d0d81de814e6c9992a170244b620b
Publikováno v:
Molecular pharmaceutics. 19(6)
Lipid nanoparticles (LNPs) are the leading technology for RNA delivery, given the success of the Pfizer/BioNTech and Moderna COVID-19 mRNA (mRNA) vaccines, and small interfering RNA (siRNA) therapies (patisiran). However, optimization of LNP process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6f2a107d3065205f00803a6463dda3
https://pubmed.ncbi.nlm.nih.gov/35604765
https://pubmed.ncbi.nlm.nih.gov/35604765
Autor:
Cameron Webb, Shell Ip, Nuthan V. Bathula, Petya Popova, Shekinah K. V. Soriano, Han Han Ly, Burcu Eryilmaz, Viet Anh Nguyen Huu, Richard Broadhead, Martin Rabel, Ian Villamagna, Suraj Abraham, Vahid Raeesi, Anitha Thomas, Samuel Clarke, Euan C. Ramsay, Yvonne Perrie, Anna K. Blakney
Publikováno v:
Molecular Pharmaceutics. 19:1047-1058
The coronavirus disease of 2019 (COVID-19) pandemic launched an unprecedented global effort to rapidly develop vaccines to stem the spread of the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2). Messenger ribonucleic acid (mRNA) vacc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e995c530ae0e8c61d2cdfb06a3fe193e
https://doi.org/10.1021/acs.molpharmaceut.2c00010
https://doi.org/10.1021/acs.molpharmaceut.2c00010