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Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

Publikováno v: McNae, I W, Kinkead, J, Malik, D, Yen, L-H, Walker, M K, Swain, C, Webster, S P, Gray, N, Fernandes, P M, Myburgh, E, Blackburn, E A, Ritchie, R, Austin, C, Wear, M A, Highton, A J, Keats, A J, Vong, A, Dornan, J, Mottram, J C, Michels, P A M, Pettit, S & Walkinshaw, M D 2021, ' Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice ', Nature Communications, vol. 12, no. 1, 1052 . https://doi.org/10.1038/s41467-021-21273-6
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

The parasitic protist Trypanosoma brucei is the causative agent of Human African Trypanosomiasis, also known as sleeping sickness. The parasite enters the blood via the bite of the tsetse fly where it is wholly reliant on glycolysis for the productio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799da05836121fe3900af19fdb8614ee
https://hdl.handle.net/20.500.11820/ba80df50-0eee-4cf5-92f8-bfbfbb7b3473

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A Comparison of Senior Student Affairs Officer and Student Affairs Preparatory Program Faculty Expectations of Entry-Level Professionals' Competencies

Autor: Marilee J. Bresciani, Baramee Peper Anan, Reynaldo Monzon, Jessica Oyler, John L. Hoffman, Kelsey F. Brown, Amy M. Dickerson, Linda K. Vong

Publikováno v: Journal of Student Affairs Research and Practice. 48:463-479

This survey research project compared and contrasted faculty and SSAO expectations for discrete new professional competencies. Findings revealed few significant differences. This study further examined differences between expected and perceived level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab0c3f0096c97e791eb62c8552467e4c
https://doi.org/10.2202/1949-6605.6270

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Bifunctional crosslinking ligands for transthyretin

Autor: Stéphanie Deroo, Graham W. Taylor, Christopher J. Swain, Simon Kolstoe, Martin D. Smith, Palma Mangione, Antonio K. Vong, Vittorio Bellotti, Stephan Ellmerich, Carol V. Robinson, Robert J. Broadbridge, Mark B. Pepys, Glenys A. Tennent, Victoria A. Steadman, Joanne R. Thurston, Steve P. Wood

Publikováno v: Mangione, P P, Deroo, S, Ellmerich, S, Bellotti, V, Kolstoe, S, Wood, S P, Robinson, C V, Smith, M D, Tennent, G A, Broadbridge, R J, Council, C E, Thurston, J R, Steadman, V A, Vong, A K, Swain, C J, Pepys, M B & Taylor, G W 2015, ' Bifunctional crosslinking ligands for transthyretin ', Open Biology, vol. 5, no. 9 . https://doi.org/10.1098/rsob.150105
Open biology, 5 (9
Open Biology
Open Biology, Vol 5, Iss 9 (2015)

Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a035d44cdef6210ce634969e39aef832
https://researchportal.port.ac.uk/ws/files/2995143/Simon_K.pdf

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Differential regulation of Pyk2 phosphorylation at Tyr-402 and Tyr-580 in intestinal epithelial cells: Roles of calcium, Src, Rho kinase, and the cytoskeleton

Autor: Sheung K. Vong, Steven S. Wu, Enrique Rozengurt, Rodrigo Jacamo

Publikováno v: Cellular Signalling. 18:1932-1940

The calcium-dependent proline-rich tyrosine kinase Pyk2 is activated by tyrosine phosphorylation, associates with focal adhesion proteins, and has been linked to proliferative and migratory responses in a variety of mesenchymal and epithelial cell ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c486136e5fb98a7b623afb7401e8362c
https://doi.org/10.1016/j.cellsig.2006.02.013

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Definition of neonatal hypoglycaemia: Is there a change?

Autor: S. K. Vong, T. H. H. G. Koh

Publikováno v: Journal of Paediatrics and Child Health. 32:302-305

Objective: To compare the definitions of neonatal hypoglycaemia in textbooks and among paediatricians in 1992 with those used in 1986. Methodology: A questionnaire was sent to 420 neonatal paediatricians in the UK and to 88 Australian neonatal paedia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c630eb284ed96d16803fdbce752e9fa4
https://doi.org/10.1111/j.1440-1754.1996.tb02558.x

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Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands

Autor: Simon E. Ward, Christopher N. Johnson, Peter J. Lovell, Claire M. Scott, Paul W. Smith, Geoffrey Stemp, Kevin M. Thewlis, Antonio K. Vong, Jeannette M. Watson

Publikováno v: Bioorganicmedicinal chemistry letters. 17(18)

A series of 5-(piperidinylethyloxy)quinoline 5-HT(1) receptor ligands have been studied by elaboration of the series of dual 5-HT(1)-SSRIs reported previously. These new compounds display a different pharmacological profile with potent affinity acros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ed17365ab63b1b61ad61fab6d589cc
https://pubmed.ncbi.nlm.nih.gov/17629698

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