Zobrazeno 1 - 10
of 39
pro vyhledávání: '"A K, Tzinia"'
Autor:
Christos G. Gkogkas, Arkady Khoutorsky, Ruifeng Cao, Seyed Mehdi Jafarnejad, Masha Prager-Khoutorsky, Nikolaos Giannakas, Archontia Kaminari, Apostolia Fragkouli, Karim Nader, Theodore J. Price, Bruce W. Konicek, Jeremy R. Graff, Athina K. Tzinia, Jean-Claude Lacaille, Nahum Sonenberg
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1742-1755 (2014)
Summary: Fragile X syndrome (FXS) is the leading genetic cause of autism. Mutations in Fmr1 (fragile X mental retardation 1 gene) engender exaggerated translation resulting in dendritic spine dysmorphogenesis, synaptic plasticity alterations, and beh
Externí odkaz:
https://doaj.org/article/d348f628d1a6424e9e4314b93bf95198
Publikováno v:
Neurobiology of Disease, Vol 70, Iss , Pp 179-189 (2014)
Accumulation of amyloid-β (Αβ) peptide is believed to play a central role in the pathogenesis of Alzheimer's disease (AD). Lowering Aβ levels in the brain may thus improve synaptic and cognitive deficits observed in AD patients. In the non-amyloi
Externí odkaz:
https://doaj.org/article/6c7f330d3f1a4bfdb95f1bf04803525b
Autor:
Argiris A. Talamagas, Spiros Efthimiopoulos, Effie C. Tsilibary, Maria E. Figueiredo-Pereira, Athina K. Tzinia
Publikováno v:
Neurobiology of Disease, Vol 28, Iss 3, Pp 304-315 (2007)
To understand matrix metalloproteinase-9 (MMP-9) involvement in Alzheimer’s disease, we examined mechanisms mediating increased expression of MMP-9 in the presence of Abeta(1–40) and the role of MMP-9 on amyloid precursor protein (APP) processing
Externí odkaz:
https://doaj.org/article/e0d2f2a9e7074cf8816ecaac557dd31e
Publikováno v:
Journal of Alzheimer's Disease. 64:1-16
Matrix metalloprotease 9 (MMP-9) is a 92 kDa type IV collagenase and a member of the family of endopeptidases. MMP-9 is involved in the degradation of extracellular matrix components, tissue remodeling, cellular receptor stripping, and processing of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbb56022338ed2402cddfbcedd12b6a
https://doi.org/10.3233/jad-180035
https://doi.org/10.3233/jad-180035
Autor:
Marzena Stefaniuk, Athina K. Tzinia, Barbara Pijet, Agnieszka Kostrzewska-Ksiezyk, Photini Effie Tsilibary, Leszek Kaczmarek
Publikováno v:
Molecular Neurobiology
Posttraumatic epilepsy (PTE) is a recurrent seizure disorder that often develops secondary to traumatic brain injury (TBI) that is caused by an external mechanical force. Recent evidence shows that the brain extracellular matrix plays a major role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce66229ecdfa701f0355f1b673d0593
https://doi.org/10.1007/s12035-018-1061-5
https://doi.org/10.1007/s12035-018-1061-5
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
A hallmark of Alzheimer’s disease (AD) is the accumulation of oligomeric amyloid-β (Aβ) peptide, which may be primarily responsible for neuronal dysfunction. Insulin signaling provides a defense mechanism against oligomer-induced neuronal loss. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d33e9ad819e0f5419a550667da24a2a
http://europepmc.org/articles/PMC5429641
http://europepmc.org/articles/PMC5429641
Autor:
Angeliki Chroni, Marina Sagnou, Effie C. Tsilibary, Ioannis Dafnis, Athina K. Tzinia, Letta Argyri, Efstratios Stratikos
Publikováno v:
Scientific Reports
The apolipoprotein (apo) E4 isoform is the strongest risk factor for late-onset Alzheimer’s disease (AD). ApoE4 is more susceptible to proteolysis than apoE2 and apoE3 isoforms and carboxyl-terminal truncated apoE4 forms have been found in AD patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dda079c53bd4d767be07a2b265c37e6
https://doi.org/10.1038/srep30654
https://doi.org/10.1038/srep30654
Publikováno v:
Neuroscience. 210:21-32
Apolipoprotein (apo) E4 isoform, a major risk factor for Alzheimer disease (AD), is more susceptible to proteolysis than apoE2 and apoE3 isoforms. ApoE4 fragments have been found in AD patients' brain. In the present study, we examined the effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0b270f6446ab3e5abb85bcc4d72d8fa
https://doi.org/10.1016/j.neuroscience.2012.03.013
https://doi.org/10.1016/j.neuroscience.2012.03.013
Autor:
Antonios Stamatakis, Athina K. Tzinia, Costas Papatheodoropoulos, Fotini Stylianopoulou, Effie C. Tsilibary, Spiros Georgopoulos, Apostolia Fragkouli
Publikováno v:
Journal of Neurochemistry. 121:239-251
Evidence accumulating during the past few years points to a significant role of matrix metalloproteinase 9 (MMP9) enzymatic activity in synaptic plasticity and cognitive processes. We have previously demonstrated that MMP9 is involved in receptor-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ca358db1ae394f395c8694792838576
https://doi.org/10.1111/j.1471-4159.2011.07637.x
https://doi.org/10.1111/j.1471-4159.2011.07637.x
Autor:
Vasiliki Kalfakakou, Matthew Tzurbakis, Anastasios D. Georgoulis, Vasileios Fotopoulos, Athina K. Tzinia, Stamatina Levidiotou-Stefanou
Publikováno v:
Knee Surgery, Sports Traumatology, Arthroscopy. 20:1159-1167
PURPOSE: In cases of septic knee arthritis, there is excess of matrix metalloproteinases (MMPs) over tissue inhibitors of metalloproteinases (TIMPs), due to enhanced expression and activation that are induced by bacteria in comparison with rheumatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09eb8f8469a623f4f5b2a7242d988575
https://doi.org/10.1007/s00167-011-1676-9
https://doi.org/10.1007/s00167-011-1676-9