Zobrazeno 1 - 10
of 106
pro vyhledávání: '"A K, Straus"'
Autor:
Chanel C. La, Stephanie A. Smith, Sreeparna Vappala, Reheman Adili, Catherine E. Luke, Srinivas Abbina, Haiming D. Luo, Irina Chafeeva, Matthew Drayton, Louise A. Creagh, Maria de Guadalupe Jaraquemada-Peláez, Nicole Rhoads, Manu Thomas Kalathottukaren, Peter K. Henke, Suzana K. Straus, Caigan Du, Edward M. Conway, Michael Holinstat, Charles A. Haynes, James H. Morrissey, Jayachandran N. Kizhakkedathu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Current treatments to prevent thrombosis, namely anticoagulants and platelets antagonists, remain complicated by the persistent risk of bleeding. Improved therapeutic strategies that diminish this risk would have a huge clinical impact. Anti
Externí odkaz:
https://doaj.org/article/57c0f006deb246efb5209ae08db2193f
Autor:
Felix L. Santana, Karel Estrada, Morgan A. Alford, Bing C. Wu, Melanie Dostert, Lucas Pedraz, Noushin Akhoundsadegh, Pavneet Kalsi, Evan F. Haney, Suzana K. Straus, Gerardo Corzo, Robert E. W. Hancock
Publikováno v:
Antibiotics, Vol 11, Iss 11, p 1603 (2022)
Host defense peptides (HDPs) represent an alternative way to address the emergence of antibiotic resistance. Crocodylians are interesting species for the study of these molecules because of their potent immune system, which confers high resistance to
Externí odkaz:
https://doaj.org/article/d2e8b5659058444793f86ae59e3ca87f
Autor:
Keng-Shuo Pi, Daria Bortolotti, Yurou Sang, Giovanna Schiuma, Silvia Beltrami, Sabrina Rizzo, Alessandra Bortoluzzi, Eleonora Baldi, A. Louise Creagh, Charles A. Haynes, Roberta Rizzo, Suzana K. Straus
Publikováno v:
Viruses, Vol 14, Iss 11, p 2384 (2022)
A number of studies have suggested that human herpesvirus 6A (HHV-6A) may play a role in multiple sclerosis (MS). Three possible hypotheses have been investigated: (1) U24 from HHV-6A (U24-6A) mimics myelin basic protein (MBP) through analogous phosp
Externí odkaz:
https://doaj.org/article/357b2295c4ec4a3a9c63046ff5c04217
Publikováno v:
Viruses, Vol 14, Iss 2, p 281 (2022)
Multiple sclerosis (MS) is a debilitating disease that arises from immune system attacks to the protective myelin sheath that covers nerve fibers and ensures optimal communication between brain and body. Although the cause of MS is unknown, a number
Externí odkaz:
https://doaj.org/article/0a317054a8cd4c729fd586bb95d0ac5b
Autor:
Nigare Raheem, Suzana K. Straus
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
The antibiotic crisis has led to a pressing need for alternatives such as antimicrobial peptides (AMPs). Recent work has shown that these molecules have great potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, an
Externí odkaz:
https://doaj.org/article/cf116b6e6a244f55b2dd1752dc442a2d
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Current research has demonstrated that small cationic amphipathic peptides have strong potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and anti-inflammatories. Although traditionally termed antimicrobial pepti
Externí odkaz:
https://doaj.org/article/6fa96e3aa5ba41c58f599db57f852107
Publikováno v:
Molecules, Vol 25, Iss 13, p 3048 (2020)
Antimicrobial peptides (AMPs), otherwise known as host defence peptides (HDPs), are naturally occurring biomolecules expressed by a large array of species across the phylogenetic kingdoms. They have great potential to combat microbial infections by d
Externí odkaz:
https://doaj.org/article/864af9dee05042bf939b73478762c681
Publikováno v:
Journal of Medicinal Chemistry. 63:9228-9236
Host-defense peptides have drawn significant attention as new drugs or drug adjuvants to combat multidrug-resistant bacteria. In this study, we report the development of cyclic derivatives of the immunomodulatory and antibiofilm innate defense regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc571e3d76817ce7212a6cad5eb98070
https://doi.org/10.1021/acs.jmedchem.0c00303
https://doi.org/10.1021/acs.jmedchem.0c00303
Publikováno v:
Biomolecules, Vol 8, Iss 1, p 4 (2018)
Antibiotic resistance is projected as one of the greatest threats to human health in the future and hence alternatives are being explored to combat resistance. Antimicrobial peptides (AMPs) have shown great promise, because use of AMPs leads bacteria
Externí odkaz:
https://doaj.org/article/b028aa568c524f2d9d8f2589b1217f6a
Autor:
Robert E. W. Hancock, Noushin Akhoundsadegh, Morgan A. Alford, Hashem Etayash, Matthew Drayton, Suzana K. Straus
Publikováno v:
Journal of medicinal chemistry. 64(22)
Effective anti-infective therapies are required to offset the rise in antibiotic resistance. A novel vancomycin-innate defense regulator conjugate (V-IDR1018) was constructed with multimodal functionality, including bacterial killing, biofilm eradica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2c577e50c26a5de40b073e822174d1
https://pubmed.ncbi.nlm.nih.gov/35048687
https://pubmed.ncbi.nlm.nih.gov/35048687