Zobrazeno 1 - 10
of 28
pro vyhledávání: '"A K, Snabaitis"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The type 2A protein phosphatase regulatory protein alpha4 (α4) constitutes an anti-apoptotic protein in non-cardiac tissue, however it’s anti-apoptotic properties in the heart are poorly defined. To this end, we knocked down α4 protein e
Externí odkaz:
https://doaj.org/article/f0ba749b7041452ca2c8f5079170e608
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
The type 2A protein phosphatase regulatory protein alpha4 (α4) constitutes an anti-apoptotic protein in non-cardiac tissue, however it’s anti-apoptotic properties in the heart are poorly defined. To this end, we knocked down α4 protein expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3128814525006e922bf3df52d04de82d
https://doaj.org/article/f0ba749b7041452ca2c8f5079170e608
https://doaj.org/article/f0ba749b7041452ca2c8f5079170e608
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract
With the emergence of the third infectious and virulent coronavirus within the past two decades, it has become increasingly important to understand how the virus causes infection. This will inform therapeutic strategies that t
With the emergence of the third infectious and virulent coronavirus within the past two decades, it has become increasingly important to understand how the virus causes infection. This will inform therapeutic strategies that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74004e5d018cb1a0b95f13416c4e6494
https://eprints.kingston.ac.uk/id/eprint/49936/6/Wren-S-49936-AAM.pdf
https://eprints.kingston.ac.uk/id/eprint/49936/6/Wren-S-49936-AAM.pdf
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86234 (2014)
The enzymatic activity of the type 2A protein phosphatase (PP2A) holoenzyme, a major serine/threonine phosphatase in the heart, is conferred by its catalytic subunit (PP2AC). PP2AC activity and subcellular localisation can be regulated by reversible
Externí odkaz:
https://doaj.org/article/deea8de7b77b476a9376fdf694e17ca7
Autor:
Michael R. Longman, Asvi Francois, Andrew K. Snabaitis, Michael J. Shattock, Jonathan Cowan, Ali Ryan, Olga Eleftheriadou, Brian E. Wadzinski, Richard J. Heads, Andrii Boguslavskyi
Publikováno v:
Basic Research in Cardiology
Cardiac physiology and hypertrophy are regulated by the phosphorylation status of many proteins, which is partly controlled by a poorly defined type 2A protein phosphatase-alpha4 intracellular signalling axis. Quantitative PCR analysis revealed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275eb352c1b09c3cf51a9bcb2b49be51
https://eprints.kingston.ac.uk/id/eprint/38213/6/Eleftheriadou-O-38213-VoR.pdf
https://eprints.kingston.ac.uk/id/eprint/38213/6/Eleftheriadou-O-38213-VoR.pdf
Autor:
R A G, da Silva, C P, Churchward, A V, Karlyshev, O, Eleftheriadou, A K, Snabaitis, M R, Longman, A, Ryan, R, Griffin
Publikováno v:
British journal of pharmacology. 174(14)
The level of cell surface expression of the meningococcal vaccine antigen, Factor H binding protein (FHbp) varies between and within strains and this limits the breadth of strains that can be targeted by FHbp-based vaccines. The molecular pathway con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1692848faabc34dad80747a727694a98
https://pubmed.ncbi.nlm.nih.gov/27784136
https://pubmed.ncbi.nlm.nih.gov/27784136
Autor:
Noelia Lezcano, Andrew K. Snabaitis, Cecilia Mundiña-Weilenmann, Metin Avkiran, Alicia Mattiazzi, Martin Vila-Petroff, Carlos Alfredo Valverde, María Ana Cristina Huergo
Publikováno v:
Journal of Molecular and Cellular Cardiology. 49:106-112
article i nfo + /H + exchanger Calcium/calmodulin-dependent protein kinase The Na + /H + exchanger (NHE-1) plays a key role in pHi recovery from acidosis and is regulated by pHi and the ERK1/2-dependent phosphorylation pathway. Since acidosis increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433e43b375543c51009999a1d30114c8
https://doi.org/10.1016/j.yjmcc.2009.12.007
https://doi.org/10.1016/j.yjmcc.2009.12.007
Publikováno v:
Journal of Biological Chemistry. 278:31676-31684
Activity of the Na+/H+ exchanger (NHE) isoform 1 (NHE1) is increased by intracellular acidosis through the interaction of intracellular H+ with an allosteric modifier site in the transport domain. Additional regulation is achieved via kinase-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86f1384da177645ece23dd0ade49ac29
https://doi.org/10.1074/jbc.m304400200
https://doi.org/10.1074/jbc.m304400200
Publikováno v:
Cardiovascular Research. 53:470-480
To characterise the effects of exogenous H(2)O(2) on sarcolemmal Na(+)/H(+) exchanger (NHE) activity and determine the roles of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (p38 MAPK) and protein kinase C (PKC) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164ba6f86388306d815fb29236f2941a
https://doi.org/10.1016/s0008-6363(01)00464-3
https://doi.org/10.1016/s0008-6363(01)00464-3
Publikováno v:
PloS one
PLoS ONE, Vol 9, Iss 1, p e86234 (2014)
PLoS ONE
PLoS ONE, Vol 9, Iss 1, p e86234 (2014)
PLoS ONE
The enzymatic activity of the type 2A protein phosphatase (PP2A) holoenzyme, a major serine/threonine phosphatase in the heart, is conferred by its catalytic subunit (PP2AC). PP2AC activity and subcellular localisation can be regulated by reversible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261e25a519116aa583d2ad9b0c8c8b98
https://eprints.kingston.ac.uk/id/eprint/27890/1/Longman-M-27890.pdf
https://eprints.kingston.ac.uk/id/eprint/27890/1/Longman-M-27890.pdf