Zobrazeno 1 - 10
of 329
pro vyhledávání: '"A K, Smilde"'
Autor:
G. R. van der Ploeg, B. W. Brandt, B. J. F. Keijser, M. H. van der Veen, C. M. C. Volgenant, E. Zaura, A. K. Smilde, J. A. Westerhuis, A. Heintz-Buschart
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Gingivitis—the inflammation of the gums—is a reversible stage of periodontal disease. It is caused by dental plaque formation due to poor oral hygiene. However, gingivitis susceptibility involves a complex set of interactions between the
Externí odkaz:
https://doaj.org/article/e4a320cb7cea4d5f8561a265f4e0a356
Autor:
Fentaw Abegaz, Davar Abedini, Fred White, Alessandra Guerrieri, Anouk Zancarini, Lemeng Dong, Johan A. Westerhuis, Fred van Eeuwijk, Harro Bouwmeester, Age K. Smilde
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Comparing the abundance of microbial communities between different groups or obtained under different experimental conditions using count sequence data is a challenging task due to various issues such as inflated zero counts, overdispersion,
Externí odkaz:
https://doaj.org/article/f6f48eebdf9e4dd3ba16f922ee8338a6
Autor:
Lu Li, Shi Yan, Barbara M. Bakker, Huub Hoefsloot, Bo Chawes, David Horner, Morten A. Rasmussen, Age K. Smilde, Evrim Acar
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Background Analysis of time-resolved postprandial metabolomics data can improve the understanding of metabolic mechanisms, potentially revealing biomarkers for early diagnosis of metabolic diseases and advancing precision nutrition and medic
Externí odkaz:
https://doaj.org/article/869a6111589c49389fce535fe4d4cd90
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/def674e9a08a41de9f92cf9bcef78b41
Autor:
Balázs Erdős, Johan A Westerhuis, Michiel E Adriaens, Shauna D O'Donovan, Ren Xie, Cécile M Singh-Povel, Age K Smilde, Ilja C W Arts
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 6, p e1011221 (2023)
The intricate dependency structure of biological "omics" data, particularly those originating from longitudinal intervention studies with frequently sampled repeated measurements renders the analysis of such data challenging. The high-dimensionality,
Externí odkaz:
https://doaj.org/article/d897f0cf2c064a13967a005048946454
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-22 (2022)
Abstract Background Analysis of dynamic metabolomics data holds the promise to improve our understanding of underlying mechanisms in metabolism. For example, it may detect changes in metabolism due to the onset of a disease. Dynamic or time-resolved
Externí odkaz:
https://doaj.org/article/c749bd728cf54db6a88d5df49e99146c
Publikováno v:
BMC Medical Research Methodology, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Vaccine clinical studies typically provide time-resolved data on adaptive response read-outs in response to the administration of that particular vaccine to a cohort of individuals. However, modeling such data is challenged by the
Externí odkaz:
https://doaj.org/article/b3415239cea145aeabe7489dd4b2623f
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11 (2021)
Longitudinal intervention studies with repeated measurements over time are an important type of experimental design in biomedical research. Due to the advent of “omics”-sciences (genomics, transcriptomics, proteomics, metabolomics), longitudinal
Externí odkaz:
https://doaj.org/article/7bfbe33a1485452cb4d892e8cf8684d5
Autor:
Simon Leygeber, Justus L. Grossmann, Carmen Diez-Simon, Naama Karu, Anne-Charlotte Dubbelman, Amy C. Harms, Johan A. Westerhuis, Doris M. Jacobs, Peter W. Lindenburg, Margriet M. W. B. Hendriks, Brenda C. H. Ammerlaan, Marco A. van den Berg, Rudi van Doorn, Roland Mumm, Robert D. Hall, Age K. Smilde, Thomas Hankemeier
Publikováno v:
Metabolites, Vol 12, Iss 12, p 1194 (2022)
Trained sensory panels are regularly used to rate food products but do not allow for data-driven approaches to steer food product development. This study evaluated the potential of a molecular-based strategy by analyzing 27 tomato soups that were enh
Externí odkaz:
https://doaj.org/article/adf18bdfc37141909b7e469916666d8e
Autor:
Josué L. Castro-Mejía, Bekzod Khakimov, Violetta Aru, Mads V. Lind, Eva Garne, Petronela Paulová, Elnaz Tavakkoli, Lars H. Hansen, Age K. Smilde, Lars Holm, Søren B. Engelsen, Dennis S. Nielsen
Publikováno v:
Microorganisms, Vol 10, Iss 11, p 2156 (2022)
Increasing evidence indicates that the gut microbiome (GM) plays an important role in dyslipidemia. To date, however, no in-depth characterization of the associations between GM with lipoproteins distributions (LPD) among adult individuals with diver
Externí odkaz:
https://doaj.org/article/026a3f7a04784f22a5e6e072def7a2f9