Zobrazeno 1 - 10
of 46
pro vyhledávání: '"A K, Horsch"'
P113 Model based predictions of the PTG-100 pharmacodynamic responses in ulcerative colitis patients
Autor:
L. Mattheakis, N. Rao, D. Liu, K. Horsch, Lu Bai, L. Zhao, C. Fosser, R. Saralaya, T. Annamalai
Publikováno v:
Journal of Crohn's and Colitis. 11:S132-S133
Publikováno v:
Calcified Tissue International. 89:221-227
Glucocorticoid-induced osteoporosis (GCOP) is predominantly caused by inhibition of bone formation, resulting from a decrease in osteoblast numbers. Employing mouse (MBA-15.4) and human (MG-63) osteoblast cell lines, we previously found that the gluc
Publikováno v:
Molecular Endocrinology. 15:2182-2196
Treatment of HC11 mammary epithelial cells with the lactogenic hormone PRL promotes differentiation and induction of milk protein gene expression via stimulation of the Janus kinase (JAK)/signal transducer and activator of transcription pathway. We h
Autor:
John T. Cunningham, Fatima Allie-Reid, F. Stephen Hough, Macé M. Schuurmans, Jacky M. Burrin, Heidi de Wet, Andrew C.B. Cato, K Horsch, Philippa A. Hulley
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 21(12)
Steroid-induced osteoporosis is a common side effect of long-term treatment with glucocorticoid (GC) drugs. GCs have multiple systemic effects that may influence bone metabolism but also directly affect osteoblasts by decreasing proliferation. This m
Publikováno v:
Endocrinology. 144(2)
A central feature of glucocorticoid (GC)-induced osteoporosis is decreased bone formation, secondary to decreased numbers of functional osteoblasts. We find that ERK activity is essential for serum-induced osteoblast proliferation in vitro because in
Autor:
N Hynes, Holger M. Reichardt, Günther Schütz, A Kolbus, K Horsch, Hartmut Beug, Hermann Josef Gröne
Publikováno v:
European journal of endocrinology. 145(4)
OBJECTIVE: Regulation of physiological processes by glucocorticoids is achieved by binding to the glucocorticoid receptor (GR) and subsequent modulation of gene expression, either by DNA binding-dependent mechanisms or via protein-protein interaction
Publikováno v:
Endocrine-related cancer. 8(3)
ErbB receptor tyrosine kinases (RTKs) and their ligands have important roles in normal development and in human cancer. Among the ErbB receptors only ErbB2 has no direct ligand; however, ErbB2 acts as a co-receptor for the other family members, promo
Publikováno v:
Arzneimittel-Forschung. 45(4)
Sixteen hypertensive male out-patients (33-54 y), whose blood pressure (BP) had been normalized (diastolic BP90 mmHg) by treatment with a daily dose of 50 mg atenolol (CAS 29122-68-7), participated in this double-blind, placebo-controlled, parallel g
Autor:
A. D. Ho, T. Franz, T. Able, H. Lannert, V. Eckstein, K. Horsch, R. Saffrich, A. Lenze, R. Hofmann
Publikováno v:
Journal of Clinical Oncology. 24:6555-6555
6555 Background: The tracking of stem cell aging, differentiation and deterioration by gene expression profiling and proteome analysis allows the comparison of different stages. The overall aim of a proteomic study is characterization of the complex
Publikováno v:
Atherosclerosis. 26:493-504
Following the intravenous injection of tracer doses of 3H-fatty acid labelled lecithin into normally fed rabbits, minimal incorporation into serum cholesterol ester over a 6-hour period was observed. The labelled phospholipid was rapidly removed from